Carbamylated Erythropoietin Ameliorates the Metabolic Stress Induced in vivo by Severe Chronic Hypoxia

Ischemia and chronic hypoxia (CH) trigger a variety of adverse effects arising from metabolic stress that injures cells. In response to reduced O₂, hypoxia-inducible factor 1α (HIF-1α) activates erythropoietin (Epo) as well as many other target genes that counteract the effects of O₂ deficiency. Epo...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2006-11, Vol.103 (46), p.17531-17536
Hauptverfasser:	Fantacci, Monica, Bianciardi, Paola, Caretti, Anna, Coleman, Thomas R., Cerami, Anthony, Brines, Michael, Samaja, Michele
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Apoptosis Biological Sciences Blood Brain Brain hypoxia Cell nucleus Cellular immunity DNA Nucleotidylexotransferase - metabolism Epics Erythrocytes Erythropoietin - analogs & derivatives Erythropoietin - pharmacology Hypoxia Hypoxia - complications Hypoxia - drug therapy Hypoxia - metabolism Male Metabolic stress Mice Mice, Inbred ICR Neurons Receptors, Erythropoietin - metabolism Stress Stress, Physiological - drug therapy Stress, Physiological - etiology Stress, Physiological - metabolism Stress, Physiological - pathology
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