Acceptance for preventive genetic testing and prophylactic surgery in women with a family history of breast and gynaecological cancers
The fear of family members of patients with breast or gynaecologic cancer of developing a similar disease is often high. We investigated the acceptance for genetic testing of untested women with a positive family history and their attitude for prophylactic surgery. A total of 659 women with a famili...
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| Veröffentlicht in: | European journal of cancer prevention 2006-12, Vol.15 (6), p.474-479 |
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| container_title | European journal of cancer prevention |
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| creator | Ackermann, Sven Lux, Michael Patrick Fasching, Peter Andreas Strissl, Pamela Renner, Stefan Peter Poehls, Uwe Bender, Hans-Georg Beckmann, Matthias Wilhelm |
| description | The fear of family members of patients with breast or gynaecologic cancer of developing a similar disease is often high. We investigated the acceptance for genetic testing of untested women with a positive family history and their attitude for prophylactic surgery. A total of 659 women with a familial history of breast or gynaecologic cancer were asked to answer a questionnaire regarding their interest in genetic testing for breast cancer as well as for gynaecologic carcinoma and their interest in prophylactic surgery. Genetic testing is seen to be accepted by the majority of participants: 85.0 and 77.8% chose a genetic test for breast and gynaecologic cancer, respectively. Prophylactic surgery was much less chosen; prophylactic mastectomy as well as prophylactic hysterectomy or bilateral prophylactic oophorectomy was an option only for a minority of women. Genetic testing for risk assessment of healthy women with a positive family history was observed to be accepted by a majority of participants. Prophylactic surgery was an option only for a minority and was not acceptable for most of the women. |
| doi_str_mv | 10.1097/01.cej.0000220628.62610.ea |
| format | Article |
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Prophylactic surgery was an option only for a minority and was not acceptable for most of the women.</description><identifier>ISSN: 0959-8278</identifier><identifier>EISSN: 1473-5709</identifier><identifier>DOI: 10.1097/01.cej.0000220628.62610.ea</identifier><identifier>PMID: 17106324</identifier><language>eng</language><publisher>England: Lippincott Williams & Wilkins</publisher><subject>Adult ; Attitude to Health ; Breast Neoplasms - genetics ; Breast Neoplasms - prevention & control ; Breast Neoplasms - psychology ; Breast Neoplasms - surgery ; Female ; Genetic Predisposition to Disease ; Genetic Testing - psychology ; Genital Neoplasms, Female - genetics ; Genital Neoplasms, Female - prevention & control ; Genital Neoplasms, Female - psychology ; Genital Neoplasms, Female - surgery ; Humans ; Hysterectomy ; Mastectomy ; Medical History Taking ; Middle Aged ; Molecular Biology and Genetics ; Patient Acceptance of Health Care - psychology</subject><ispartof>European journal of cancer prevention, 2006-12, Vol.15 (6), p.474-479</ispartof><rights>Copyright © 2006 Lippincott Williams & Wilkins</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c254t-246e25ee2975702df5f7f65c17ad092b087161ba2d524929c09a1fb1eefc4b1b3</citedby><cites>FETCH-LOGICAL-c254t-246e25ee2975702df5f7f65c17ad092b087161ba2d524929c09a1fb1eefc4b1b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/45051646$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/45051646$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17106324$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ackermann, Sven</creatorcontrib><creatorcontrib>Lux, Michael Patrick</creatorcontrib><creatorcontrib>Fasching, Peter Andreas</creatorcontrib><creatorcontrib>Strissl, Pamela</creatorcontrib><creatorcontrib>Renner, Stefan Peter</creatorcontrib><creatorcontrib>Poehls, Uwe</creatorcontrib><creatorcontrib>Bender, Hans-Georg</creatorcontrib><creatorcontrib>Beckmann, Matthias Wilhelm</creatorcontrib><title>Acceptance for preventive genetic testing and prophylactic surgery in women with a family history of breast and gynaecological cancers</title><title>European journal of cancer prevention</title><addtitle>Eur J Cancer Prev</addtitle><description>The fear of family members of patients with breast or gynaecologic cancer of developing a similar disease is often high. We investigated the acceptance for genetic testing of untested women with a positive family history and their attitude for prophylactic surgery. A total of 659 women with a familial history of breast or gynaecologic cancer were asked to answer a questionnaire regarding their interest in genetic testing for breast cancer as well as for gynaecologic carcinoma and their interest in prophylactic surgery. Genetic testing is seen to be accepted by the majority of participants: 85.0 and 77.8% chose a genetic test for breast and gynaecologic cancer, respectively. Prophylactic surgery was much less chosen; prophylactic mastectomy as well as prophylactic hysterectomy or bilateral prophylactic oophorectomy was an option only for a minority of women. Genetic testing for risk assessment of healthy women with a positive family history was observed to be accepted by a majority of participants. Prophylactic surgery was an option only for a minority and was not acceptable for most of the women.</description><subject>Adult</subject><subject>Attitude to Health</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - prevention & control</subject><subject>Breast Neoplasms - psychology</subject><subject>Breast Neoplasms - surgery</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetic Testing - psychology</subject><subject>Genital Neoplasms, Female - genetics</subject><subject>Genital Neoplasms, Female - prevention & control</subject><subject>Genital Neoplasms, Female - psychology</subject><subject>Genital Neoplasms, Female - surgery</subject><subject>Humans</subject><subject>Hysterectomy</subject><subject>Mastectomy</subject><subject>Medical History Taking</subject><subject>Middle Aged</subject><subject>Molecular Biology and Genetics</subject><subject>Patient Acceptance of Health Care - psychology</subject><issn>0959-8278</issn><issn>1473-5709</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkcFu1DAQhi0EotvCI4AsDtyyeJzYjrlVFRSkSlzgbDnOOOtVEi92tigvwHPj7a6oD-PD98-M_vkJ-QBsC0yrTwy2DvdbVh7nTPJ2K7ksEO0LsoFG1ZVQTL8kG6aFrlqu2itynfOeMVA1yNfkChQwWfNmQ_7eOoeHxc4OqY-JHhI-4ryER6QDzrgERxfMS5gHaue-4HjYraN1J5CPacC00jDTP3HCUsOyo5Z6O4VxpbuQl1hw9LRLaPPyNGFYZ4sujnEIzo7UnTan_Ia88nbM-Pby35BfX7_8vPtWPfy4_353-1A5Lpql4o1ELhC5VsUi773wykvhQNmead6xVoGEzvJe8EZz7Zi24DtA9K7poKtvyMfz3GLk97EYM1PIDsfRzhiP2cgWBJPQFOHns9ClmHNCbw4pTDatBpg5pWAYmJKCeU7BPKVg0Jbm95ctx27C_rn1cvYieHcW7E8n-s8bwQTIRtb_AIy0kWw</recordid><startdate>20061201</startdate><enddate>20061201</enddate><creator>Ackermann, Sven</creator><creator>Lux, Michael Patrick</creator><creator>Fasching, Peter Andreas</creator><creator>Strissl, Pamela</creator><creator>Renner, Stefan Peter</creator><creator>Poehls, Uwe</creator><creator>Bender, Hans-Georg</creator><creator>Beckmann, Matthias Wilhelm</creator><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20061201</creationdate><title>Acceptance for preventive genetic testing and prophylactic surgery in women with a family history of breast and gynaecological cancers</title><author>Ackermann, Sven ; Lux, Michael Patrick ; Fasching, Peter Andreas ; Strissl, Pamela ; Renner, Stefan Peter ; Poehls, Uwe ; Bender, Hans-Georg ; Beckmann, Matthias Wilhelm</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c254t-246e25ee2975702df5f7f65c17ad092b087161ba2d524929c09a1fb1eefc4b1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Attitude to Health</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - prevention & control</topic><topic>Breast Neoplasms - psychology</topic><topic>Breast Neoplasms - surgery</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetic Testing - psychology</topic><topic>Genital Neoplasms, Female - genetics</topic><topic>Genital Neoplasms, Female - prevention & control</topic><topic>Genital Neoplasms, Female - psychology</topic><topic>Genital Neoplasms, Female - surgery</topic><topic>Humans</topic><topic>Hysterectomy</topic><topic>Mastectomy</topic><topic>Medical History Taking</topic><topic>Middle Aged</topic><topic>Molecular Biology and Genetics</topic><topic>Patient Acceptance of Health Care - psychology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ackermann, Sven</creatorcontrib><creatorcontrib>Lux, Michael Patrick</creatorcontrib><creatorcontrib>Fasching, Peter Andreas</creatorcontrib><creatorcontrib>Strissl, Pamela</creatorcontrib><creatorcontrib>Renner, Stefan Peter</creatorcontrib><creatorcontrib>Poehls, Uwe</creatorcontrib><creatorcontrib>Bender, Hans-Georg</creatorcontrib><creatorcontrib>Beckmann, Matthias Wilhelm</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of cancer prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ackermann, Sven</au><au>Lux, Michael Patrick</au><au>Fasching, Peter Andreas</au><au>Strissl, Pamela</au><au>Renner, Stefan Peter</au><au>Poehls, Uwe</au><au>Bender, Hans-Georg</au><au>Beckmann, Matthias Wilhelm</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acceptance for preventive genetic testing and prophylactic surgery in women with a family history of breast and gynaecological cancers</atitle><jtitle>European journal of cancer prevention</jtitle><addtitle>Eur J Cancer Prev</addtitle><date>2006-12-01</date><risdate>2006</risdate><volume>15</volume><issue>6</issue><spage>474</spage><epage>479</epage><pages>474-479</pages><issn>0959-8278</issn><eissn>1473-5709</eissn><abstract>The fear of family members of patients with breast or gynaecologic cancer of developing a similar disease is often high. We investigated the acceptance for genetic testing of untested women with a positive family history and their attitude for prophylactic surgery. A total of 659 women with a familial history of breast or gynaecologic cancer were asked to answer a questionnaire regarding their interest in genetic testing for breast cancer as well as for gynaecologic carcinoma and their interest in prophylactic surgery. Genetic testing is seen to be accepted by the majority of participants: 85.0 and 77.8% chose a genetic test for breast and gynaecologic cancer, respectively. Prophylactic surgery was much less chosen; prophylactic mastectomy as well as prophylactic hysterectomy or bilateral prophylactic oophorectomy was an option only for a minority of women. Genetic testing for risk assessment of healthy women with a positive family history was observed to be accepted by a majority of participants. 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| subjects | Adult Attitude to Health Breast Neoplasms - genetics Breast Neoplasms - prevention & control Breast Neoplasms - psychology Breast Neoplasms - surgery Female Genetic Predisposition to Disease Genetic Testing - psychology Genital Neoplasms, Female - genetics Genital Neoplasms, Female - prevention & control Genital Neoplasms, Female - psychology Genital Neoplasms, Female - surgery Humans Hysterectomy Mastectomy Medical History Taking Middle Aged Molecular Biology and Genetics Patient Acceptance of Health Care - psychology |
| title | Acceptance for preventive genetic testing and prophylactic surgery in women with a family history of breast and gynaecological cancers |
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