Programmed death-1 gene polymorphisms in patients with systemic lupus erythematosus in Taiwan
To investigate the role of programmed cell death-1 (PD-1) gene polymorphisms in the development of systemic lupus erythematosus (SLE) in Taiwan, 109 patients with SLE and 100 healthy controls were enrolled in this study. The PD-1 gene polymorphisms were determined by the method of polymerase chain r...
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| Veröffentlicht in: | Journal of Clinical Immunology 2006-11, Vol.26 (6), p.506-511 |
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| creator | Wang, Shu-Chen Chen, Yi-Jing Ou, Tsan-Teng Wu, Cheng-Chin Tsai, Wen-Chan Liu, Hong-Wen Yen, Jeng-Hsien |
| description | To investigate the role of programmed cell death-1 (PD-1) gene polymorphisms in the development of systemic lupus erythematosus (SLE) in Taiwan, 109 patients with SLE and 100 healthy controls were enrolled in this study. The PD-1 gene polymorphisms were determined by the method of polymerase chain reaction/restriction fragment length polymorphism. This study showed that the genotype distributions of PD-1 7209 C/T polymorphisms were significantly different between the patients with SLE and controls (P=0.002, Pc=0.018). The frequencies of the PD-1 7209 C/C genotype and PD-1 7209 C allele were significantly higher in the patients with SLE than those of the controls (P=0.001, OR=2.6, 95% CI=1.5-4.6, and P=0.002, OR=2.1, 95% CI=1.3-3.4, Pc=0.018, respectively). Moreover, the association of PD-1 7209 C with susceptibility to SLE was independent of the PD-1 ligand. This study also showed that the PD-1-536 A 7146 G 7209 C 7499 G haplotype was associated with the development of SLE in Taiwan. |
| doi_str_mv | 10.1007/s10875-006-9048-9 |
| format | Article |
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The PD-1 gene polymorphisms were determined by the method of polymerase chain reaction/restriction fragment length polymorphism. This study showed that the genotype distributions of PD-1 7209 C/T polymorphisms were significantly different between the patients with SLE and controls (P=0.002, Pc=0.018). The frequencies of the PD-1 7209 C/C genotype and PD-1 7209 C allele were significantly higher in the patients with SLE than those of the controls (P=0.001, OR=2.6, 95% CI=1.5-4.6, and P=0.002, OR=2.1, 95% CI=1.3-3.4, Pc=0.018, respectively). Moreover, the association of PD-1 7209 C with susceptibility to SLE was independent of the PD-1 ligand. This study also showed that the PD-1-536 A 7146 G 7209 C 7499 G haplotype was associated with the development of SLE in Taiwan.</description><identifier>ISSN: 0271-9142</identifier><identifier>EISSN: 1573-2592</identifier><identifier>EISSN: 1365-2567</identifier><identifier>DOI: 10.1007/s10875-006-9048-9</identifier><identifier>PMID: 17024563</identifier><identifier>CODEN: JCIMDO</identifier><language>eng</language><publisher>Netherlands: Springer Nature B.V</publisher><subject>Adult ; Antigens, CD - genetics ; Apoptosis Regulatory Proteins - genetics ; Female ; Genetic Predisposition to Disease ; Genotype ; Humans ; Lupus Erythematosus, Systemic - genetics ; Male ; Middle Aged ; Polymorphism, Genetic ; Programmed Cell Death 1 Receptor ; Taiwan</subject><ispartof>Journal of Clinical Immunology, 2006-11, Vol.26 (6), p.506-511</ispartof><rights>Springer Science+Business Media, LLC 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-921160a0103e32106bd1ed2085778aa8f6ea888f5d99e015444d855f60d542d43</citedby><cites>FETCH-LOGICAL-c386t-921160a0103e32106bd1ed2085778aa8f6ea888f5d99e015444d855f60d542d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17024563$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Shu-Chen</creatorcontrib><creatorcontrib>Chen, Yi-Jing</creatorcontrib><creatorcontrib>Ou, Tsan-Teng</creatorcontrib><creatorcontrib>Wu, Cheng-Chin</creatorcontrib><creatorcontrib>Tsai, Wen-Chan</creatorcontrib><creatorcontrib>Liu, Hong-Wen</creatorcontrib><creatorcontrib>Yen, Jeng-Hsien</creatorcontrib><title>Programmed death-1 gene polymorphisms in patients with systemic lupus erythematosus in Taiwan</title><title>Journal of Clinical Immunology</title><addtitle>J Clin Immunol</addtitle><description>To investigate the role of programmed cell death-1 (PD-1) gene polymorphisms in the development of systemic lupus erythematosus (SLE) in Taiwan, 109 patients with SLE and 100 healthy controls were enrolled in this study. The PD-1 gene polymorphisms were determined by the method of polymerase chain reaction/restriction fragment length polymorphism. This study showed that the genotype distributions of PD-1 7209 C/T polymorphisms were significantly different between the patients with SLE and controls (P=0.002, Pc=0.018). The frequencies of the PD-1 7209 C/C genotype and PD-1 7209 C allele were significantly higher in the patients with SLE than those of the controls (P=0.001, OR=2.6, 95% CI=1.5-4.6, and P=0.002, OR=2.1, 95% CI=1.3-3.4, Pc=0.018, respectively). Moreover, the association of PD-1 7209 C with susceptibility to SLE was independent of the PD-1 ligand. This study also showed that the PD-1-536 A 7146 G 7209 C 7499 G haplotype was associated with the development of SLE in Taiwan.</description><subject>Adult</subject><subject>Antigens, CD - genetics</subject><subject>Apoptosis Regulatory Proteins - genetics</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Humans</subject><subject>Lupus Erythematosus, Systemic - genetics</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polymorphism, Genetic</subject><subject>Programmed Cell Death 1 Receptor</subject><subject>Taiwan</subject><issn>0271-9142</issn><issn>1573-2592</issn><issn>1365-2567</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkUtLHEEUhQuJ6ETzA9xIkUV2ldxbr65aipgHCLrQpRTl9G2npV-pqkbm36cnMxBwk9XdfOfAuR9jFwhfEaD6lhFcZQSAFR60E_6IrdBUSkjj5Qe2Almh8KjlKfuY8ysAKCvNCTvFCqQ2Vq3Y030aX1Lse6p5TbFsBPIXGohPY7ftxzRt2txn3g58iqWloWT-1pYNz9tcqG_XvJunOXNK27KhPpYxz3_ph9i-xeGcHTexy_TpcM_Y4_ebh-uf4vbux6_rq1uxVs4W4SWihQgIipREsM81Ui3BmapyMbrGUnTONab2ngCN1rp2xjQWaqNlrdUZ-7LvndL4e6ZcQt_mNXVdHGicc7AODWhU_wXRO6mdhgX8_A58Hec0LCOCROs8KL9rwz20TmPOiZowpbaPaRsQws5Q2BsKi6GwMxT8krk8FM_Py9P_JQ5K1B-BDYsn</recordid><startdate>20061101</startdate><enddate>20061101</enddate><creator>Wang, Shu-Chen</creator><creator>Chen, Yi-Jing</creator><creator>Ou, Tsan-Teng</creator><creator>Wu, Cheng-Chin</creator><creator>Tsai, Wen-Chan</creator><creator>Liu, Hong-Wen</creator><creator>Yen, Jeng-Hsien</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20061101</creationdate><title>Programmed death-1 gene polymorphisms in patients with systemic lupus erythematosus in Taiwan</title><author>Wang, Shu-Chen ; 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The PD-1 gene polymorphisms were determined by the method of polymerase chain reaction/restriction fragment length polymorphism. This study showed that the genotype distributions of PD-1 7209 C/T polymorphisms were significantly different between the patients with SLE and controls (P=0.002, Pc=0.018). The frequencies of the PD-1 7209 C/C genotype and PD-1 7209 C allele were significantly higher in the patients with SLE than those of the controls (P=0.001, OR=2.6, 95% CI=1.5-4.6, and P=0.002, OR=2.1, 95% CI=1.3-3.4, Pc=0.018, respectively). Moreover, the association of PD-1 7209 C with susceptibility to SLE was independent of the PD-1 ligand. This study also showed that the PD-1-536 A 7146 G 7209 C 7499 G haplotype was associated with the development of SLE in Taiwan.</abstract><cop>Netherlands</cop><pub>Springer Nature B.V</pub><pmid>17024563</pmid><doi>10.1007/s10875-006-9048-9</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Antigens, CD - genetics Apoptosis Regulatory Proteins - genetics Female Genetic Predisposition to Disease Genotype Humans Lupus Erythematosus, Systemic - genetics Male Middle Aged Polymorphism, Genetic Programmed Cell Death 1 Receptor Taiwan |
| title | Programmed death-1 gene polymorphisms in patients with systemic lupus erythematosus in Taiwan |
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