Thymoquinone suppressses in vitro production of IL-5 and IL-13 by mast cells in response to lipopolysaccharide stimulation

Activated mast cells produce Th2 cytokines that regulate allergic inflammation. We have previously shown that thymoquinone (TQ) attenuated airway inflammation in a mouse model of allergic airway inflammation. The present study investigated whether TQ affects Th2 cytokine response in vitro in lipopol...

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Veröffentlicht in:	Inflammation research 2007-08, Vol.56 (8), p.345-351
1. Verfasser:	El Gazzar, M A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Benzoquinones - pharmacology Cells, Cultured GATA1 Transcription Factor - genetics GATA2 Transcription Factor - genetics Interleukin-13 - biosynthesis Interleukin-5 - biosynthesis Interleukin-5 - genetics Lipopolysaccharides - pharmacology Mast Cells - drug effects Mast Cells - metabolism NF-kappa B - metabolism Promoter Regions, Genetic Rats Transcription Factor AP-1 - metabolism
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