Effects of iron overload in a rat nutritional model of non-alcoholic fatty liver disease

: Background/Aims: This study sought to determine whether excess hepatic iron potentiates liver injury in the methionine choline‐deficient (MCD) model of non‐alcoholic fatty liver disease (NAFLD). Methods: Iron‐loaded rats were fed either MCD or control diets [MCD diet plus choline bitartrate (2 g/k...

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Veröffentlicht in:	Liver international 2006-12, Vol.26 (10), p.1258-1267
Hauptverfasser:	Kirsch, Richard, Sijtsema, Helene P., Tlali, Mpho, Marais, Adrian D., Hall, Pauline de la M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - blood Animals Body Weight Choline Deficiency - complications Disease Models, Animal Fatty Liver - etiology Fatty Liver - metabolism Fatty Liver - pathology Female fibrosis Hydroxyproline - analysis inflammation iron Iron Overload - complications Lipid Peroxidation Liver - metabolism Liver - pathology Methionine - deficiency methionine choline deficient Organ Size Rats Rats, Inbred F344 steatosis
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