Progressive Multicystic Encephalopathy: Is There More Than Hypoxia-Ischemia?

Progressive multicystic encephalopathy following prenatal or perinatal hypoxia-ischemia is a well-described phenomenon in the literature. The authors report on a term infant with a devastating encephalopathy and severe neuronal dysfunction immediately after delivery without a known antecedent of pre...

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Veröffentlicht in:Journal of child neurology 2007-05, Vol.22 (5), p.645-649
Hauptverfasser: Garten, Lars, Hueseman, Dieter, Stoltenburg-Didinger, Gisela, Felderhoff-Mueser, Ursula, Weizsaecker, Katharina, Scheer, Ianina, Boltshauser, Eugen, Obladen, Michael
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container_end_page 649
container_issue 5
container_start_page 645
container_title Journal of child neurology
container_volume 22
creator Garten, Lars
Hueseman, Dieter
Stoltenburg-Didinger, Gisela
Felderhoff-Mueser, Ursula
Weizsaecker, Katharina
Scheer, Ianina
Boltshauser, Eugen
Obladen, Michael
description Progressive multicystic encephalopathy following prenatal or perinatal hypoxia-ischemia is a well-described phenomenon in the literature. The authors report on a term infant with a devastating encephalopathy and severe neuronal dysfunction immediately after delivery without a known antecedent of prenatal or perinatal hypoxia or distress. Clinical and paraclinical findings in the patient are compared with those described in the literature. The authors focus on the specific results guiding to the final diagnosis of progressive multicystic encephalopathy and the timing of morphologic changes. As in this case, if the criteria of an acute hypoxic event sufficient to cause neonatal encephalopathy are not met, then factors other than hypoxia-ischemia may be leading to progressive multicystic encephalopathy.
doi_str_mv 10.1177/0883073807302618
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subjects Adult
Disease Progression
Female
Fetal Diseases - etiology
Fetal Diseases - pathology
Fetal Distress - complications
Humans
Hypoxia-Ischemia, Brain - etiology
Hypoxia-Ischemia, Brain - pathology
Infant, Newborn
Magnetic Resonance Imaging - methods
Pregnancy
title Progressive Multicystic Encephalopathy: Is There More Than Hypoxia-Ischemia?
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