Gender-specific effects of endogenous testosterone: Female α-estrogen receptor-deficient C57Bl/6J mice develop glomerulosclerosis

Young female mice on a C57Bl/6J (B6) background are considered glomerulosclerosis (GS)-resistant but aging B6 mice develop mild GS. Estrogen deficiency accelerates while estrogen replacement retards GS in young sclerosis-prone oligosyndactyly mutant mice on an ROP background. To explore the effects...

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Veröffentlicht in:	Kidney international 2007-08, Vol.72 (4), p.464-472
Hauptverfasser:	Elliot, S.J., Berho, M., Korach, K., Doublier, S., Lupia, E., Striker, G.E., Karl, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Albuminuria - genetics Albuminuria - metabolism Albuminuria - pathology Albuminuria - physiopathology androgens androgens receptor Animals Body Weight Cells, Cultured Disease Models, Animal Dose-Response Relationship, Drug Estradiol - metabolism Estrogen Receptor alpha - deficiency Estrogen Receptor alpha - genetics Estrogen Receptor alpha - metabolism Estrogen Receptor beta - deficiency Estrogen Receptor beta - genetics Estrogen Receptor beta - metabolism estrogens Extracellular Matrix Proteins - metabolism Female Genetic Predisposition to Disease genetic traits Glomerulosclerosis, Focal Segmental - complications Glomerulosclerosis, Focal Segmental - genetics Glomerulosclerosis, Focal Segmental - metabolism Glomerulosclerosis, Focal Segmental - pathology Glomerulosclerosis, Focal Segmental - physiopathology kidney Kidney Glomerulus - drug effects Kidney Glomerulus - metabolism Kidney Glomerulus - pathology Kidney Glomerulus - physiopathology Male menopause Mesangial Cells - metabolism Mesangial Cells - pathology Mice Mice, Inbred C57BL Mice, Knockout Organ Size Ovariectomy Promoter Regions, Genetic Receptors, Androgen - genetics Receptors, Androgen - metabolism RNA, Messenger - metabolism Sex Factors Signal Transduction Testosterone - metabolism Testosterone - pharmacology Transfection Transforming Growth Factor beta1 - genetics Transforming Growth Factor beta1 - metabolism
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