A Chemical Genetic Screen for Cell Cycle Inhibitors in Zebrafish Embryos

Chemical genetic screening is an effective strategy to identify compounds that alter a specific biological phenotype. As a complement to cell line screens, multicellular organism screens may reveal additional compounds. The zebrafish embryo is ideal for small molecule studies because of its small si...

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Veröffentlicht in:	Chemical biology & drug design 2006-10, Vol.68 (4), p.213-219
Hauptverfasser:	Murphey, Ryan D., Stern, Howard M., Straub, Christian T., Zon, Leonard I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aphidicolin - administration & dosage cell cycle Cell Cycle - drug effects Cell Cycle - genetics Cell Cycle - physiology Cell Line chemical genetics Dimethyl Sulfoxide - administration & dosage DNA - metabolism Drug Evaluation, Preclinical - methods Embryo, Nonmammalian - cytology Embryo, Nonmammalian - drug effects Embryo, Nonmammalian - metabolism Flow Cytometry Histones - metabolism Immunohistochemistry Mice Mitosis - drug effects Mitosis - genetics Mitosis - physiology NIH 3T3 Cells Nocodazole - administration & dosage Pharmaceutical Preparations - administration & dosage Pharmaceutical Preparations - classification Phenotype Phosphorylation - drug effects screen small molecule Tubulin - metabolism zebrafish Zebrafish - embryology Zebrafish - genetics
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