Hyperforin and its analogues inhibit CYP3A4 enzyme activity

Hyperforin and its four oxidized analogues were isolated from St. John’s wort and evaluated for their effects on CYP3A4 enzyme activity. Literature indicates that herb–drug interaction of St. John’s wort is largely due to increased metabolism of the co-administered drugs that are the substrates of c...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Phytochemistry (Oxford) 2006-12, Vol.67 (23), p.2550-2560
Hauptverfasser:	Lee, Ju-young, Duke, Rujee K., Tran, Van H., Hook, James M., Duke, Colin C.
Format:	Artikel
Sprache:	eng
Schlagworte:	acylhloroglucinols Acylphloroglucinols Biological and medical sciences Bridged Bicyclo Compounds - chemistry Bridged Bicyclo Compounds - isolation & purification Bridged Bicyclo Compounds - pharmacology Chemical constitution cytochrome P-450 Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System - metabolism enzyme activity enzyme inhibition Fundamental and applied biological sciences. Psychology Furoadhyperforin Furohyperforin General pharmacology Humans Hyperforin Hypericum - chemistry Hypericum perforatum isozymes Medical sciences medicinal plants Molecular Structure MS and CYP3A4 enzyme NMR Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phloroglucinol - analogs & derivatives Phloroglucinol - chemistry Phloroglucinol - isolation & purification Phloroglucinol - pharmacology Plant physiology and development recombinant proteins St. John’s wort Terpenes - chemistry Terpenes - isolation & purification Terpenes - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!