Label-Free Optical Detection and Tracking of Single Virions Bound to Their Receptors in Supported Membrane Bilayers

We apply an interferometric optical detection scheme to image and track unlabeled single virions. Individual simian virus 40 virions and uninfectious virus-like particles were imaged on a glass substrate and on a supported membrane bilayer. Moreover, single unlabeled virions were tracked when bound...

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Veröffentlicht in:	Nano letters 2007-08, Vol.7 (8), p.2263-2266
Hauptverfasser:	Ewers, Helge, Jacobsen, Volker, Klotzsch, Enrico, Smith, Alicia E, Helenius, Ari, Sandoghdar, Vahid
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Biological and medical sciences Fundamental and applied biological sciences. Psychology General aspects, investigation technics, apparatus Lipid Bilayers - chemistry Microscopy, Polarization - methods Protein Binding Receptors, Virus - chemistry Receptors, Virus - ultrastructure Simian virus 40 Staining and Labeling Tissues, organs and organisms biophysics Virion - ultrastructure
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