A controlled clinical trial comparing the safety and immunogenicity of a new adjuvanted hepatitis B vaccine with a standard hepatitis B vaccine

A randomised trial was conducted in 285 adults not immune to hepatitis B (HB) to compare the safety and immunogenicity of a commercial aluminium-adjuvanted HB vaccine with and without an additional new adjuvant (AgB/RC-210-04 or AgB ® study groups, respectively). The additional adjuvant RC-529 is a...

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Veröffentlicht in:	Vaccine 2006-11, Vol.24 (49), p.7167-7174
Hauptverfasser:	Dupont, Juan, Altclas, Javier, Lepetic, Alejandro, Lombardo, Mónica, Vázquez, Vicente, Salgueira, Claudia, Seigelchifer, Mauricio, Arndtz, Nathaly, Antunez, Ernesto, von Eschen, Kenneth, Janowicz, Zbigniew
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2-Dipalmitoylphosphatidylcholine Adjuvant Adjuvants, Immunologic Adolescent Adult Aluminum Antigens Applied microbiology Biological and medical sciences Chronic illnesses Clinical trials Cohort Studies Confidence intervals Disease Dose-Response Relationship, Immunologic Double-Blind Method Excipients Female Fundamental and applied biological sciences. Psychology Hepatitis Hepatitis B Hepatitis B - immunology Hepatitis B - prevention & control Hepatitis B Antibodies - analysis Hepatitis B Antibodies - biosynthesis Hepatitis B Surface Antigens - analysis Hepatitis B Surface Antigens - immunology Hepatitis B Vaccines - administration & dosage Hepatitis B Vaccines - adverse effects Hepatitis B Vaccines - immunology Hepatitis B virus Herpes viruses Human viral diseases Humans Immunogenicity Infections Infectious diseases Male Medical sciences Microbiology Mortality Proteins Safety Suspensions Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Viral diseases Viral hepatitis
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