Antiviral effects of mifepristone on human immunodeficiency virus type-1 (HIV-1): Targeting Vpr and its cellular partner, the glucocorticoid receptor (GR)

The HIV-1 viral protein R, Vpr, increases virus replication in T cells and is necessary for the optimal infection of primary monocytes/macrophages and other non-dividing cells. Vpr interacts with the cellular glucocorticoid receptor (GR) and transactivates the HIV-1 LTR through glucocorticoid respon...

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Veröffentlicht in:	Antiviral research 2006-12, Vol.72 (3), p.224-232
Hauptverfasser:	Schafer, Elizabeth A., Venkatachari, Narasimhan J., Ayyavoo, Velpandi
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-HIV Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral Antiviral agents Biological and medical sciences Cell Line Cells, Cultured Dose-Response Relationship, Drug Gene Expression Regulation, Viral - drug effects Gene Products, vpr - metabolism Glucocorticoid receptor HeLa Cells HIV Core Protein p24 - biosynthesis HIV Long Terminal Repeat - genetics HIV Long Terminal Repeat - physiology HIV-1 HIV-1 - drug effects HIV-1 - physiology Human immunodeficiency virus 1 Humans Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - virology Macrophages - cytology Macrophages - drug effects Macrophages - virology Medical sciences Mifepristone Mifepristone - pharmacology Pharmacology. Drug treatments Promoter Regions, Genetic Receptors, Glucocorticoid - metabolism Transcriptional Activation Virus Activation Virus Latency Virus Replication - drug effects Vpr vpr Gene Products, Human Immunodeficiency Virus
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