Comparison of transmission of Mycoplasma hyopneumoniae in vaccinated and non-vaccinated populations
A transmission experiment was performed to quantify the effect of vaccination on the transmission of Mycoplasma hyopneumoniae ( M. hyopneumoniae) in nursery piglets by means of an adjusted reproduction ratio ( R n ). Thirty piglets, vaccinated at 1 week of age, and 30 non-vaccinated piglets, free of...
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| Veröffentlicht in: | Vaccine 2006-11, Vol.24 (49), p.7081-7086 |
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| creator | Meyns, Tom Dewulf, Jeroen de Kruif, Aart Calus, Dries Haesebrouck, Freddy Maes, Dominiek |
| description | A transmission experiment was performed to quantify the effect of vaccination on the transmission of
Mycoplasma hyopneumoniae (
M. hyopneumoniae) in nursery piglets by means of an adjusted reproduction ratio (
R
n
). Thirty piglets, vaccinated at 1 week of age, and 30 non-vaccinated piglets, free of
M. hyopneumoniae, were housed in six separate pens. In each pen, three animals that were intratracheally inoculated with
M. hyopneumoniae, were housed together with seven contact piglets during the conventional nursery period of 6 weeks. At the end of the study, the infectious status of the animals was determined based on results of nPCR performed on bronchoalveolar lavage fluid. The
R
n
-value in the vaccinated group was 2.38 (1.07–7.53) while in the non-vaccinated group, an
R
n
-value of 3.51 (1.51–9.34) was observed, both not significantly different from each other (
p
=
0.77). Under the actual experimental conditions, transmission of
M. hyopneumoniae in nursery piglets was only numerically lower in vaccinated groups. In addition, vaccination with a conventional vaccine could not prevent the establishment of
M. hyopneumoniae organisms in the lung. |
| doi_str_mv | 10.1016/j.vaccine.2006.07.004 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68140866</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0264410X06008176</els_id><sourcerecordid>68140866</sourcerecordid><originalsourceid>FETCH-LOGICAL-c523t-b1d59979dc0ad8edc79dd6fe4b2cffc8f42b2920c8c6592d19d3354907b89db73</originalsourceid><addsrcrecordid>eNqFkU2L1TAUhoMozp3Rn6B0o7hpPfloPlYiFx2FETcK7kKapJhLm9SmHbj_3lxaGFfOKh8857wneRB6haHBgPn7U3NvrA3RNwSANyAaAPYEHbAUtCYtlk_RAQhnNcPw6wpd53wCgJZi9RxdYa4oo4IfkD2mcTJzyClWqa-W2cQ8hpzDdv52tmkaTB5N9fucpujXMcVgfBViteWbxbvKRFfFFOt_rqY0rYNZSp_8Aj3rzZD9y329QT8_f_px_FLffb_9evx4V9uW0KXusGuVEspZME56Z8vW8d6zjti-t7JnpCOKgJWWt4o4rBylLVMgOqlcJ-gNerv1neb0Z_V50eUl1g-DiT6tWXOJGUjOHwWxYkCpIAV893-wBRCCKnIJbzfUzinn2fd6msNo5rPGoC_G9EnvxvTFmAahi7FS93qPWLvRu4eqXVEB3uyAydYMfTFkQ37gJJFMwmXWDxvnyxffBz_rbIOP1rswe7tol8Ijo_wFuiC4tw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1500773927</pqid></control><display><type>article</type><title>Comparison of transmission of Mycoplasma hyopneumoniae in vaccinated and non-vaccinated populations</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Meyns, Tom ; Dewulf, Jeroen ; de Kruif, Aart ; Calus, Dries ; Haesebrouck, Freddy ; Maes, Dominiek</creator><creatorcontrib>Meyns, Tom ; Dewulf, Jeroen ; de Kruif, Aart ; Calus, Dries ; Haesebrouck, Freddy ; Maes, Dominiek</creatorcontrib><description>A transmission experiment was performed to quantify the effect of vaccination on the transmission of
Mycoplasma hyopneumoniae (
M. hyopneumoniae) in nursery piglets by means of an adjusted reproduction ratio (
R
n
). Thirty piglets, vaccinated at 1 week of age, and 30 non-vaccinated piglets, free of
M. hyopneumoniae, were housed in six separate pens. In each pen, three animals that were intratracheally inoculated with
M. hyopneumoniae, were housed together with seven contact piglets during the conventional nursery period of 6 weeks. At the end of the study, the infectious status of the animals was determined based on results of nPCR performed on bronchoalveolar lavage fluid. The
R
n
-value in the vaccinated group was 2.38 (1.07–7.53) while in the non-vaccinated group, an
R
n
-value of 3.51 (1.51–9.34) was observed, both not significantly different from each other (
p
=
0.77). Under the actual experimental conditions, transmission of
M. hyopneumoniae in nursery piglets was only numerically lower in vaccinated groups. In addition, vaccination with a conventional vaccine could not prevent the establishment of
M. hyopneumoniae organisms in the lung.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2006.07.004</identifier><identifier>PMID: 16934376</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Antibodies, Bacterial - immunology ; Applied microbiology ; Bacterial Vaccines - immunology ; Bacteriology ; Biological and medical sciences ; Bronchoalveolar Lavage Fluid - cytology ; Female ; Fluorescent Antibody Technique ; Fundamental and applied biological sciences. Psychology ; Lung - microbiology ; Lung - pathology ; Male ; Microbiology ; Miscellaneous ; Mycoplasma hyopneumoniae ; Mycoplasma hyopneumoniae - immunology ; Nasal Cavity - immunology ; Nasal Cavity - pathology ; Pneumonia of Swine, Mycoplasmal - immunology ; Pneumonia of Swine, Mycoplasmal - pathology ; Pneumonia of Swine, Mycoplasmal - transmission ; Reverse Transcriptase Polymerase Chain Reaction ; Swine ; Transmission ; Vaccination ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><ispartof>Vaccine, 2006-11, Vol.24 (49), p.7081-7086</ispartof><rights>2006 Elsevier Ltd</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c523t-b1d59979dc0ad8edc79dd6fe4b2cffc8f42b2920c8c6592d19d3354907b89db73</citedby><cites>FETCH-LOGICAL-c523t-b1d59979dc0ad8edc79dd6fe4b2cffc8f42b2920c8c6592d19d3354907b89db73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0264410X06008176$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18284802$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16934376$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meyns, Tom</creatorcontrib><creatorcontrib>Dewulf, Jeroen</creatorcontrib><creatorcontrib>de Kruif, Aart</creatorcontrib><creatorcontrib>Calus, Dries</creatorcontrib><creatorcontrib>Haesebrouck, Freddy</creatorcontrib><creatorcontrib>Maes, Dominiek</creatorcontrib><title>Comparison of transmission of Mycoplasma hyopneumoniae in vaccinated and non-vaccinated populations</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>A transmission experiment was performed to quantify the effect of vaccination on the transmission of
Mycoplasma hyopneumoniae (
M. hyopneumoniae) in nursery piglets by means of an adjusted reproduction ratio (
R
n
). Thirty piglets, vaccinated at 1 week of age, and 30 non-vaccinated piglets, free of
M. hyopneumoniae, were housed in six separate pens. In each pen, three animals that were intratracheally inoculated with
M. hyopneumoniae, were housed together with seven contact piglets during the conventional nursery period of 6 weeks. At the end of the study, the infectious status of the animals was determined based on results of nPCR performed on bronchoalveolar lavage fluid. The
R
n
-value in the vaccinated group was 2.38 (1.07–7.53) while in the non-vaccinated group, an
R
n
-value of 3.51 (1.51–9.34) was observed, both not significantly different from each other (
p
=
0.77). Under the actual experimental conditions, transmission of
M. hyopneumoniae in nursery piglets was only numerically lower in vaccinated groups. In addition, vaccination with a conventional vaccine could not prevent the establishment of
M. hyopneumoniae organisms in the lung.</description><subject>Animals</subject><subject>Antibodies, Bacterial - immunology</subject><subject>Applied microbiology</subject><subject>Bacterial Vaccines - immunology</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Bronchoalveolar Lavage Fluid - cytology</subject><subject>Female</subject><subject>Fluorescent Antibody Technique</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Lung - microbiology</subject><subject>Lung - pathology</subject><subject>Male</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Mycoplasma hyopneumoniae</subject><subject>Mycoplasma hyopneumoniae - immunology</subject><subject>Nasal Cavity - immunology</subject><subject>Nasal Cavity - pathology</subject><subject>Pneumonia of Swine, Mycoplasmal - immunology</subject><subject>Pneumonia of Swine, Mycoplasmal - pathology</subject><subject>Pneumonia of Swine, Mycoplasmal - transmission</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Swine</subject><subject>Transmission</subject><subject>Vaccination</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2L1TAUhoMozp3Rn6B0o7hpPfloPlYiFx2FETcK7kKapJhLm9SmHbj_3lxaGFfOKh8857wneRB6haHBgPn7U3NvrA3RNwSANyAaAPYEHbAUtCYtlk_RAQhnNcPw6wpd53wCgJZi9RxdYa4oo4IfkD2mcTJzyClWqa-W2cQ8hpzDdv52tmkaTB5N9fucpujXMcVgfBViteWbxbvKRFfFFOt_rqY0rYNZSp_8Aj3rzZD9y329QT8_f_px_FLffb_9evx4V9uW0KXusGuVEspZME56Z8vW8d6zjti-t7JnpCOKgJWWt4o4rBylLVMgOqlcJ-gNerv1neb0Z_V50eUl1g-DiT6tWXOJGUjOHwWxYkCpIAV893-wBRCCKnIJbzfUzinn2fd6msNo5rPGoC_G9EnvxvTFmAahi7FS93qPWLvRu4eqXVEB3uyAydYMfTFkQ37gJJFMwmXWDxvnyxffBz_rbIOP1rswe7tol8Ijo_wFuiC4tw</recordid><startdate>20061130</startdate><enddate>20061130</enddate><creator>Meyns, Tom</creator><creator>Dewulf, Jeroen</creator><creator>de Kruif, Aart</creator><creator>Calus, Dries</creator><creator>Haesebrouck, Freddy</creator><creator>Maes, Dominiek</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20061130</creationdate><title>Comparison of transmission of Mycoplasma hyopneumoniae in vaccinated and non-vaccinated populations</title><author>Meyns, Tom ; Dewulf, Jeroen ; de Kruif, Aart ; Calus, Dries ; Haesebrouck, Freddy ; Maes, Dominiek</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c523t-b1d59979dc0ad8edc79dd6fe4b2cffc8f42b2920c8c6592d19d3354907b89db73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Antibodies, Bacterial - immunology</topic><topic>Applied microbiology</topic><topic>Bacterial Vaccines - immunology</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Bronchoalveolar Lavage Fluid - cytology</topic><topic>Female</topic><topic>Fluorescent Antibody Technique</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Lung - microbiology</topic><topic>Lung - pathology</topic><topic>Male</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Mycoplasma hyopneumoniae</topic><topic>Mycoplasma hyopneumoniae - immunology</topic><topic>Nasal Cavity - immunology</topic><topic>Nasal Cavity - pathology</topic><topic>Pneumonia of Swine, Mycoplasmal - immunology</topic><topic>Pneumonia of Swine, Mycoplasmal - pathology</topic><topic>Pneumonia of Swine, Mycoplasmal - transmission</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Swine</topic><topic>Transmission</topic><topic>Vaccination</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meyns, Tom</creatorcontrib><creatorcontrib>Dewulf, Jeroen</creatorcontrib><creatorcontrib>de Kruif, Aart</creatorcontrib><creatorcontrib>Calus, Dries</creatorcontrib><creatorcontrib>Haesebrouck, Freddy</creatorcontrib><creatorcontrib>Maes, Dominiek</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meyns, Tom</au><au>Dewulf, Jeroen</au><au>de Kruif, Aart</au><au>Calus, Dries</au><au>Haesebrouck, Freddy</au><au>Maes, Dominiek</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of transmission of Mycoplasma hyopneumoniae in vaccinated and non-vaccinated populations</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2006-11-30</date><risdate>2006</risdate><volume>24</volume><issue>49</issue><spage>7081</spage><epage>7086</epage><pages>7081-7086</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>A transmission experiment was performed to quantify the effect of vaccination on the transmission of
Mycoplasma hyopneumoniae (
M. hyopneumoniae) in nursery piglets by means of an adjusted reproduction ratio (
R
n
). Thirty piglets, vaccinated at 1 week of age, and 30 non-vaccinated piglets, free of
M. hyopneumoniae, were housed in six separate pens. In each pen, three animals that were intratracheally inoculated with
M. hyopneumoniae, were housed together with seven contact piglets during the conventional nursery period of 6 weeks. At the end of the study, the infectious status of the animals was determined based on results of nPCR performed on bronchoalveolar lavage fluid. The
R
n
-value in the vaccinated group was 2.38 (1.07–7.53) while in the non-vaccinated group, an
R
n
-value of 3.51 (1.51–9.34) was observed, both not significantly different from each other (
p
=
0.77). Under the actual experimental conditions, transmission of
M. hyopneumoniae in nursery piglets was only numerically lower in vaccinated groups. In addition, vaccination with a conventional vaccine could not prevent the establishment of
M. hyopneumoniae organisms in the lung.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>16934376</pmid><doi>10.1016/j.vaccine.2006.07.004</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0264-410X |
| ispartof | Vaccine, 2006-11, Vol.24 (49), p.7081-7086 |
| issn | 0264-410X 1873-2518 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68140866 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Antibodies, Bacterial - immunology Applied microbiology Bacterial Vaccines - immunology Bacteriology Biological and medical sciences Bronchoalveolar Lavage Fluid - cytology Female Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Lung - microbiology Lung - pathology Male Microbiology Miscellaneous Mycoplasma hyopneumoniae Mycoplasma hyopneumoniae - immunology Nasal Cavity - immunology Nasal Cavity - pathology Pneumonia of Swine, Mycoplasmal - immunology Pneumonia of Swine, Mycoplasmal - pathology Pneumonia of Swine, Mycoplasmal - transmission Reverse Transcriptase Polymerase Chain Reaction Swine Transmission Vaccination Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) |
| title | Comparison of transmission of Mycoplasma hyopneumoniae in vaccinated and non-vaccinated populations |
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