Muscle Wasting and Impaired Muscle Regeneration in a Murine Model of Chronic Pulmonary Inflammation

Muscle wasting and increased circulating levels of inflammatory cytokines, including TNF-alpha, are common features of chronic obstructive pulmonary disease. To investigate whether inflammation of the lung is responsible for systemic inflammation and muscle wasting, we adopted a mouse model of pulmo...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2006-12, Vol.35 (6), p.689-696
Hauptverfasser:	Langen, Ramon C. J, Schols, Annemie M. W. J, Kelders, Marco C. J. M, van der Velden, Jos L. J, Wouters, Emiel F. M, Janssen-Heininger, Yvonne M. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation - drug effects Cell Line Cell Proliferation - drug effects Chronic Disease Disease Models, Animal Histones - genetics Histones - metabolism Lung - metabolism Mice Mice, Inbred C57BL Mice, Transgenic Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Muscle, Skeletal - physiopathology Muscular Atrophy - etiology Muscular Atrophy - metabolism Muscular Atrophy - pathology Muscular Atrophy - physiopathology Myoblasts, Skeletal - drug effects Myoblasts, Skeletal - pathology Myosin Heavy Chains - genetics Myosin Heavy Chains - metabolism Organ Size Pneumonia - complications Pneumonia - metabolism Pneumonia - pathology Pneumonia - physiopathology Promoter Regions, Genetic Pulmonary Surfactant-Associated Protein C - genetics Receptors, Tumor Necrosis Factor, Type II - blood Receptors, Tumor Necrosis Factor, Type II - genetics Receptors, Tumor Necrosis Factor, Type II - metabolism Regeneration RNA, Messenger - metabolism Tumor Necrosis Factor-alpha - blood Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Tumor Necrosis Factor-alpha - pharmacology
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