Random variability in congenital hypothyroidism from thyroid dysgenesis over 16 years in québec
Research on the etiology of congenital hypothyroidism from thyroid dysgenesis (CHTD) (comprising mostly ectopy and agenesis) over the past decade has focused on genetic mechanisms. However, the possibility that environmental factors might be involved has been raised by studies showing a seasonal var...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2007-08, Vol.92 (8), p.3158-3161 |
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| creator | DELADOËY, Johnny BELANGER, Nicole VAN VLIET, Guy |
| description | Research on the etiology of congenital hypothyroidism from thyroid dysgenesis (CHTD) (comprising mostly ectopy and agenesis) over the past decade has focused on genetic mechanisms. However, the possibility that environmental factors might be involved has been raised by studies showing a seasonal variability of the incidence of CHTD.
The objective of this study was to assess the variability in incidence of CHTD in the province of Québec, Canada.
The Québec provincial newborn screening database was analyzed from January 1990 to December 2005. Only cases of permanent congenital hypothyroidism with thyroid ectopy or agenesis on scintigraphy were analyzed.
During the study period, 1,303,341 children were screened, and 424 cases of permanent congenital hypothyroidism were diagnosed, giving an overall incidence of 1:3074. Of these, 306 had CHTD (overall incidence 1:4259) from either ectopy (n = 231) or agenesis (n = 75). Over the 16 yr of the study, this incidence remained stable (P = 0.57), and no significant variability in monthly incidence was found (P = 0.87).
The incidence of CHTD did not vary over the observation period, and its monthly variation was random. Therefore, environmental factors do not appear to play a significant role in the etiology of CHTD. |
| doi_str_mv | 10.1210/jc.2007-0527 |
| format | Article |
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The objective of this study was to assess the variability in incidence of CHTD in the province of Québec, Canada.
The Québec provincial newborn screening database was analyzed from January 1990 to December 2005. Only cases of permanent congenital hypothyroidism with thyroid ectopy or agenesis on scintigraphy were analyzed.
During the study period, 1,303,341 children were screened, and 424 cases of permanent congenital hypothyroidism were diagnosed, giving an overall incidence of 1:3074. Of these, 306 had CHTD (overall incidence 1:4259) from either ectopy (n = 231) or agenesis (n = 75). Over the 16 yr of the study, this incidence remained stable (P = 0.57), and no significant variability in monthly incidence was found (P = 0.87).
The incidence of CHTD did not vary over the observation period, and its monthly variation was random. Therefore, environmental factors do not appear to play a significant role in the etiology of CHTD.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2007-0527</identifier><identifier>PMID: 17504897</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Adolescent ; Biological and medical sciences ; Choristoma - epidemiology ; Congenital Hypothyroidism - epidemiology ; Databases, Factual ; Endocrinopathies ; Environment ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Infant, Newborn ; Male ; Medical sciences ; Neonatal Screening ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Quebec - epidemiology ; Seasons ; Thyroid Dysgenesis - epidemiology ; Thyroid. Thyroid axis (diseases) ; Thyrotropin - blood ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: endocrinology</subject><ispartof>The journal of clinical endocrinology and metabolism, 2007-08, Vol.92 (8), p.3158-3161</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18997581$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17504897$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DELADOËY, Johnny</creatorcontrib><creatorcontrib>BELANGER, Nicole</creatorcontrib><creatorcontrib>VAN VLIET, Guy</creatorcontrib><title>Random variability in congenital hypothyroidism from thyroid dysgenesis over 16 years in québec</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Research on the etiology of congenital hypothyroidism from thyroid dysgenesis (CHTD) (comprising mostly ectopy and agenesis) over the past decade has focused on genetic mechanisms. However, the possibility that environmental factors might be involved has been raised by studies showing a seasonal variability of the incidence of CHTD.
The objective of this study was to assess the variability in incidence of CHTD in the province of Québec, Canada.
The Québec provincial newborn screening database was analyzed from January 1990 to December 2005. Only cases of permanent congenital hypothyroidism with thyroid ectopy or agenesis on scintigraphy were analyzed.
During the study period, 1,303,341 children were screened, and 424 cases of permanent congenital hypothyroidism were diagnosed, giving an overall incidence of 1:3074. Of these, 306 had CHTD (overall incidence 1:4259) from either ectopy (n = 231) or agenesis (n = 75). Over the 16 yr of the study, this incidence remained stable (P = 0.57), and no significant variability in monthly incidence was found (P = 0.87).
The incidence of CHTD did not vary over the observation period, and its monthly variation was random. Therefore, environmental factors do not appear to play a significant role in the etiology of CHTD.</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Choristoma - epidemiology</subject><subject>Congenital Hypothyroidism - epidemiology</subject><subject>Databases, Factual</subject><subject>Endocrinopathies</subject><subject>Environment</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neonatal Screening</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Quebec - epidemiology</subject><subject>Seasons</subject><subject>Thyroid Dysgenesis - epidemiology</subject><subject>Thyroid. Thyroid axis (diseases)</subject><subject>Thyrotropin - blood</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vertebrates: endocrinology</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0MtKxDAYhuEgijOO7lxLNrrrmFObZCmDJxgQRMFdTXNwMvQ0STvQS_I6vDErVlz9fPDwLn4AzjFaYoLR9VYvCUI8QSnhB2COJUsTjiU_BHOECE4kJ28zcBLjFiHMWEqPwQzzFDEh-Ry8P6vaNBXcq-BV4UvfDdDXUDf1h619p0q4Gdqm2wyh8cbHCrow6mlDM8SR2egjbPY2QJzBwaoQfxK7_uuzsPoUHDlVRns23QV4vbt9WT0k66f7x9XNOmlxJruEZcIIhzgjhRPGUmcMNUhJgqUwVBdKSStp5gpGsNPYMKYVw45xjgi1GaILcPXbbUOz623s8spHbctS1bbpY54JTAWRfIQXE-yLypq8Db5SYcj_fjKCywmoqFXpgqq1j_9OSMnTsfYN2iZySA</recordid><startdate>20070801</startdate><enddate>20070801</enddate><creator>DELADOËY, Johnny</creator><creator>BELANGER, Nicole</creator><creator>VAN VLIET, Guy</creator><general>Endocrine Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20070801</creationdate><title>Random variability in congenital hypothyroidism from thyroid dysgenesis over 16 years in québec</title><author>DELADOËY, Johnny ; BELANGER, Nicole ; VAN VLIET, Guy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p169t-468d8f0742bf8de3fdd3d0a92198d3cbaa9e936fb421fc1d44ca41f477023e603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Choristoma - epidemiology</topic><topic>Congenital Hypothyroidism - epidemiology</topic><topic>Databases, Factual</topic><topic>Endocrinopathies</topic><topic>Environment</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neonatal Screening</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Quebec - epidemiology</topic><topic>Seasons</topic><topic>Thyroid Dysgenesis - epidemiology</topic><topic>Thyroid. Thyroid axis (diseases)</topic><topic>Thyrotropin - blood</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DELADOËY, Johnny</creatorcontrib><creatorcontrib>BELANGER, Nicole</creatorcontrib><creatorcontrib>VAN VLIET, Guy</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DELADOËY, Johnny</au><au>BELANGER, Nicole</au><au>VAN VLIET, Guy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Random variability in congenital hypothyroidism from thyroid dysgenesis over 16 years in québec</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2007-08-01</date><risdate>2007</risdate><volume>92</volume><issue>8</issue><spage>3158</spage><epage>3161</epage><pages>3158-3161</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>Research on the etiology of congenital hypothyroidism from thyroid dysgenesis (CHTD) (comprising mostly ectopy and agenesis) over the past decade has focused on genetic mechanisms. However, the possibility that environmental factors might be involved has been raised by studies showing a seasonal variability of the incidence of CHTD.
The objective of this study was to assess the variability in incidence of CHTD in the province of Québec, Canada.
The Québec provincial newborn screening database was analyzed from January 1990 to December 2005. Only cases of permanent congenital hypothyroidism with thyroid ectopy or agenesis on scintigraphy were analyzed.
During the study period, 1,303,341 children were screened, and 424 cases of permanent congenital hypothyroidism were diagnosed, giving an overall incidence of 1:3074. Of these, 306 had CHTD (overall incidence 1:4259) from either ectopy (n = 231) or agenesis (n = 75). Over the 16 yr of the study, this incidence remained stable (P = 0.57), and no significant variability in monthly incidence was found (P = 0.87).
The incidence of CHTD did not vary over the observation period, and its monthly variation was random. Therefore, environmental factors do not appear to play a significant role in the etiology of CHTD.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>17504897</pmid><doi>10.1210/jc.2007-0527</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Oxford University Press Journals Current; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Biological and medical sciences Choristoma - epidemiology Congenital Hypothyroidism - epidemiology Databases, Factual Endocrinopathies Environment Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Humans Infant, Newborn Male Medical sciences Neonatal Screening Non tumoral diseases. Target tissue resistance. Benign neoplasms Quebec - epidemiology Seasons Thyroid Dysgenesis - epidemiology Thyroid. Thyroid axis (diseases) Thyrotropin - blood Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology |
| title | Random variability in congenital hypothyroidism from thyroid dysgenesis over 16 years in québec |
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