Extensive studies on perfusion method plus intra-bone marrow-bone marrow transplantation using cynomolgus monkeys
The collection of bone marrow cells (BMCs) using a perfusion method has been advantageous not only because of the low contamination of BMCs with T cells from the peripheral blood but also the enrichment of stromal cells, which support hemopoiesis. Before the application of this new method to humans,...
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| Veröffentlicht in: | Stem cells (Dayton, Ohio) Ohio), 2007-08, Vol.25 (8), p.2098-2103 |
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| creator | Inaba, Muneo Adachi, Yasushi Hisha, Hiroko Hosaka, Naoki Maki, Masahiko Ueda, Yusuke Koike, Yasushi Miyake, Takeshi Fukui, Junichi Cui, Yunze Mukaide, Hiromi Koike, Naoko Omae, Mariko Mizokami, Tomomi Shigematsu, Akio Sakaguchi, Yutaku Tsuda, Masanobu Okazaki, Satoshi Wang, Xiaoli Li, Qing Nishida, Akihisa Ando, Yugo Guo, Kequan Song, Changye Cui, Wenhao Feng, Wei Katou, Junko Sado, Katuyuki Nakamura, Shuji Ikehara, Susumu |
| description | The collection of bone marrow cells (BMCs) using a perfusion method has been advantageous not only because of the low contamination of BMCs with T cells from the peripheral blood but also the enrichment of stromal cells, which support hemopoiesis. Before the application of this new method to humans, its safety needed to be confirmed using cynomolgus monkeys. We therefore performed the perfusion method on more than 100 cynomolgus monkeys using the long bones (such as the humerus and femur) and also the iliac bones (for human application); in the more than 150 trials to date, there have been no accidental deaths. Furthermore, the technical safety of a new method for the intra-bone marrow (IBM) injection of BMCs (termed IBM-bone marrow transplantation) has also been confirmed using 30 monkeys. Disclosure of potential conflicts of interest is found at the end of this article. |
| doi_str_mv | 10.1634/stemcells.2007-0174 |
| format | Article |
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| ispartof | Stem cells (Dayton, Ohio), 2007-08, Vol.25 (8), p.2098-2103 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Bone Marrow Cells - cytology Bone Marrow Transplantation - adverse effects Bone Marrow Transplantation - methods Cell Count Cell Separation Cynomolgus Macaca fascicularis Perfusion - methods Tissue and Organ Harvesting - adverse effects Tissue and Organ Harvesting - instrumentation Tissue and Organ Harvesting - methods Transplantation, Homologous |
| title | Extensive studies on perfusion method plus intra-bone marrow-bone marrow transplantation using cynomolgus monkeys |
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