Prediction of pathological stages before prostatectomy in prostate cancer patients: Analysis of 12 systematic prostate needle biopsy specimens
Objective: To identify the most reliable predictor of the pathological stage among multiple parameters obtained by performing systematic biopsies and to assess the predictive value of any identified parameters in combination with the prostate specific antigen and the Gleason scores. Methods: We ex...
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| Veröffentlicht in: | International journal of urology 2007-08, Vol.14 (8), p.704-708 |
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| creator | Park, Eun-Ah Lee, Hak Jong Kim, Kwang Gi Kim, Seung Hyup Lee, Sang Eun Choe, Ghee Young |
| description | Objective: To identify the most reliable predictor of the pathological stage among multiple parameters obtained by performing systematic biopsies and to assess the predictive value of any identified parameters in combination with the prostate specific antigen and the Gleason scores.
Methods: We examined 5 biopsy parameters from 12 systematic needle biopsy results in 104 consecutive prostate cancer patients who underwent prostatectomy: the number of cores positive for cancer, percentage of positive biopsy cores, total linear cancer length (absolute sum of tumor length at each core), percentage cancer length (total cancer length divided by total length of cores obtained ×100), and maximum cancer core length. The predictive values of these parameters were assessed using multivariate logistic analysis and receiver operating characteristic analysis. We evaluated whether the most reliable biopsy parameter in combination with traditional variables show better predictability of the pathological stage than traditional variables alone by receiver operating characteristic analysis.
Results: Of 104 patients, 85 (82.9%) had organ confined cancer and 19 (17.1%) showed extraprostatic extension. Of the five parameters examined, maximum cancer length was found to best predict pathological staging. Although insignificant, adding results of maximum cancer length to prostate specific antigen and Gleason scores improved predictability. Of 41 patients with a maximum cancer length of |
| doi_str_mv | 10.1111/j.1442-2042.2007.01795.x |
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Methods: We examined 5 biopsy parameters from 12 systematic needle biopsy results in 104 consecutive prostate cancer patients who underwent prostatectomy: the number of cores positive for cancer, percentage of positive biopsy cores, total linear cancer length (absolute sum of tumor length at each core), percentage cancer length (total cancer length divided by total length of cores obtained ×100), and maximum cancer core length. The predictive values of these parameters were assessed using multivariate logistic analysis and receiver operating characteristic analysis. We evaluated whether the most reliable biopsy parameter in combination with traditional variables show better predictability of the pathological stage than traditional variables alone by receiver operating characteristic analysis.
Results: Of 104 patients, 85 (82.9%) had organ confined cancer and 19 (17.1%) showed extraprostatic extension. Of the five parameters examined, maximum cancer length was found to best predict pathological staging. Although insignificant, adding results of maximum cancer length to prostate specific antigen and Gleason scores improved predictability. Of 41 patients with a maximum cancer length of <0.9 cm, PSA of <16 ng/mL, and Gleason score of <7, none showed extraprostatic extension.
Conclusions: The maximum cancer length was found to be the most reliable predictor of disease staging. The findings of a maximum cancer length of <0.9 cm, PSA of <16 ng/mL, and a Gleason score of <7 can suggest an organ‐confined disease.]]></description><identifier>ISSN: 0919-8172</identifier><identifier>EISSN: 1442-2042</identifier><identifier>DOI: 10.1111/j.1442-2042.2007.01795.x</identifier><identifier>PMID: 17681059</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>adenocarcinoma ; Adenocarcinoma - pathology ; Adenocarcinoma - surgery ; Aged ; Biopsy, Needle ; Humans ; Male ; Middle Aged ; needle biopsy ; Neoplasm Staging ; Predictive Value of Tests ; prostate ; prostate specific antigen ; Prostatectomy ; Prostatic Neoplasms - pathology ; Prostatic Neoplasms - surgery ; ROC Curve ; staging</subject><ispartof>International journal of urology, 2007-08, Vol.14 (8), p.704-708</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5085-b222c3f60bcf95574213a17826b7c4cba94b190cac4cebbe8736a6eaba01c2043</citedby><cites>FETCH-LOGICAL-c5085-b222c3f60bcf95574213a17826b7c4cba94b190cac4cebbe8736a6eaba01c2043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1442-2042.2007.01795.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1442-2042.2007.01795.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17681059$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Eun-Ah</creatorcontrib><creatorcontrib>Lee, Hak Jong</creatorcontrib><creatorcontrib>Kim, Kwang Gi</creatorcontrib><creatorcontrib>Kim, Seung Hyup</creatorcontrib><creatorcontrib>Lee, Sang Eun</creatorcontrib><creatorcontrib>Choe, Ghee Young</creatorcontrib><title>Prediction of pathological stages before prostatectomy in prostate cancer patients: Analysis of 12 systematic prostate needle biopsy specimens</title><title>International journal of urology</title><addtitle>Int J Urol</addtitle><description><![CDATA[Objective: To identify the most reliable predictor of the pathological stage among multiple parameters obtained by performing systematic biopsies and to assess the predictive value of any identified parameters in combination with the prostate specific antigen and the Gleason scores.
Methods: We examined 5 biopsy parameters from 12 systematic needle biopsy results in 104 consecutive prostate cancer patients who underwent prostatectomy: the number of cores positive for cancer, percentage of positive biopsy cores, total linear cancer length (absolute sum of tumor length at each core), percentage cancer length (total cancer length divided by total length of cores obtained ×100), and maximum cancer core length. The predictive values of these parameters were assessed using multivariate logistic analysis and receiver operating characteristic analysis. We evaluated whether the most reliable biopsy parameter in combination with traditional variables show better predictability of the pathological stage than traditional variables alone by receiver operating characteristic analysis.
Results: Of 104 patients, 85 (82.9%) had organ confined cancer and 19 (17.1%) showed extraprostatic extension. Of the five parameters examined, maximum cancer length was found to best predict pathological staging. Although insignificant, adding results of maximum cancer length to prostate specific antigen and Gleason scores improved predictability. Of 41 patients with a maximum cancer length of <0.9 cm, PSA of <16 ng/mL, and Gleason score of <7, none showed extraprostatic extension.
Conclusions: The maximum cancer length was found to be the most reliable predictor of disease staging. The findings of a maximum cancer length of <0.9 cm, PSA of <16 ng/mL, and a Gleason score of <7 can suggest an organ‐confined disease.]]></description><subject>adenocarcinoma</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma - surgery</subject><subject>Aged</subject><subject>Biopsy, Needle</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>needle biopsy</subject><subject>Neoplasm Staging</subject><subject>Predictive Value of Tests</subject><subject>prostate</subject><subject>prostate specific antigen</subject><subject>Prostatectomy</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Prostatic Neoplasms - surgery</subject><subject>ROC Curve</subject><subject>staging</subject><issn>0919-8172</issn><issn>1442-2042</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1P3DAQhq2qVdlC_0LlU28JHufDcSUOCJUvoQISqL1ZtndCvSRxGmfF5k_0N9fprpYrvtgz8z7j0TuEUGApxHO8SiHPecJZzlPOmEgZCFmkm3dksS-8JwsmQSYVCH5APoWwYgwyDtVHcgCirIAVckH-3g24dHZ0vqO-pr0ef_vGPzmrGxpG_YSBGqz9gLQffEyMaEffTtR1-wS1urM4zKzDbgzf6Gmnmym4MHcETsMURmxj1b4yHeKyQWqc78NEQ4_WtdiFI_Kh1k3Az7v7kDyef384u0xubi-uzk5vEluwqkgM59xmdcmMrWVRiJxDpkFUvDTC5tZomRuQzOoYoDFYiazUJWqjGdhoTnZIvm77xoH-rDGMqnXBYtPoDv06qGhPVgEvo7DaCm2cPAxYq35wrR4mBUzNu1ArNVuuZsvVvAv1fxdqE9Evuz_WpsXlK7gzPwpOtoIX1-D05sbq6vpxfkU-2fIu-rvZ83p4VqXIRKF-_rhQlw-_7u-uz6WS2T_otKsB</recordid><startdate>200708</startdate><enddate>200708</enddate><creator>Park, Eun-Ah</creator><creator>Lee, Hak Jong</creator><creator>Kim, Kwang Gi</creator><creator>Kim, Seung Hyup</creator><creator>Lee, Sang Eun</creator><creator>Choe, Ghee Young</creator><general>Blackwell Publishing Asia</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200708</creationdate><title>Prediction of pathological stages before prostatectomy in prostate cancer patients: Analysis of 12 systematic prostate needle biopsy specimens</title><author>Park, Eun-Ah ; Lee, Hak Jong ; Kim, Kwang Gi ; Kim, Seung Hyup ; Lee, Sang Eun ; Choe, Ghee Young</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5085-b222c3f60bcf95574213a17826b7c4cba94b190cac4cebbe8736a6eaba01c2043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>adenocarcinoma</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma - surgery</topic><topic>Aged</topic><topic>Biopsy, Needle</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>needle biopsy</topic><topic>Neoplasm Staging</topic><topic>Predictive Value of Tests</topic><topic>prostate</topic><topic>prostate specific antigen</topic><topic>Prostatectomy</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Prostatic Neoplasms - surgery</topic><topic>ROC Curve</topic><topic>staging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Eun-Ah</creatorcontrib><creatorcontrib>Lee, Hak Jong</creatorcontrib><creatorcontrib>Kim, Kwang Gi</creatorcontrib><creatorcontrib>Kim, Seung Hyup</creatorcontrib><creatorcontrib>Lee, Sang Eun</creatorcontrib><creatorcontrib>Choe, Ghee Young</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Eun-Ah</au><au>Lee, Hak Jong</au><au>Kim, Kwang Gi</au><au>Kim, Seung Hyup</au><au>Lee, Sang Eun</au><au>Choe, Ghee Young</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prediction of pathological stages before prostatectomy in prostate cancer patients: Analysis of 12 systematic prostate needle biopsy specimens</atitle><jtitle>International journal of urology</jtitle><addtitle>Int J Urol</addtitle><date>2007-08</date><risdate>2007</risdate><volume>14</volume><issue>8</issue><spage>704</spage><epage>708</epage><pages>704-708</pages><issn>0919-8172</issn><eissn>1442-2042</eissn><abstract><![CDATA[Objective: To identify the most reliable predictor of the pathological stage among multiple parameters obtained by performing systematic biopsies and to assess the predictive value of any identified parameters in combination with the prostate specific antigen and the Gleason scores.
Methods: We examined 5 biopsy parameters from 12 systematic needle biopsy results in 104 consecutive prostate cancer patients who underwent prostatectomy: the number of cores positive for cancer, percentage of positive biopsy cores, total linear cancer length (absolute sum of tumor length at each core), percentage cancer length (total cancer length divided by total length of cores obtained ×100), and maximum cancer core length. The predictive values of these parameters were assessed using multivariate logistic analysis and receiver operating characteristic analysis. We evaluated whether the most reliable biopsy parameter in combination with traditional variables show better predictability of the pathological stage than traditional variables alone by receiver operating characteristic analysis.
Results: Of 104 patients, 85 (82.9%) had organ confined cancer and 19 (17.1%) showed extraprostatic extension. Of the five parameters examined, maximum cancer length was found to best predict pathological staging. Although insignificant, adding results of maximum cancer length to prostate specific antigen and Gleason scores improved predictability. Of 41 patients with a maximum cancer length of <0.9 cm, PSA of <16 ng/mL, and Gleason score of <7, none showed extraprostatic extension.
Conclusions: The maximum cancer length was found to be the most reliable predictor of disease staging. The findings of a maximum cancer length of <0.9 cm, PSA of <16 ng/mL, and a Gleason score of <7 can suggest an organ‐confined disease.]]></abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>17681059</pmid><doi>10.1111/j.1442-2042.2007.01795.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | adenocarcinoma Adenocarcinoma - pathology Adenocarcinoma - surgery Aged Biopsy, Needle Humans Male Middle Aged needle biopsy Neoplasm Staging Predictive Value of Tests prostate prostate specific antigen Prostatectomy Prostatic Neoplasms - pathology Prostatic Neoplasms - surgery ROC Curve staging |
| title | Prediction of pathological stages before prostatectomy in prostate cancer patients: Analysis of 12 systematic prostate needle biopsy specimens |
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