Are there common genetic and environmental factors behind the endophenotypes associated with the metabolic syndrome
Aims/hypothesis The cluster of obesity, insulin resistance, dyslipidaemia and hypertension, called the metabolic syndrome, has been suggested as a risk factor for cardiovascular disease and type 2 diabetes. The aim of the present study was to evaluate whether there are common genetic and environment...
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| Veröffentlicht in: | Diabetologia 2007-09, Vol.50 (9), p.1880-1888 |
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| container_title | Diabetologia |
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| creator | Benyamin, B Sørensen, T. I. A Schousboe, K Fenger, M Visscher, P. M Kyvik, K. O |
| description | Aims/hypothesis The cluster of obesity, insulin resistance, dyslipidaemia and hypertension, called the metabolic syndrome, has been suggested as a risk factor for cardiovascular disease and type 2 diabetes. The aim of the present study was to evaluate whether there are common genetic and environmental factors influencing this cluster in a general population of twin pairs. Materials and methods A multivariate genetic analysis was performed on nine endophenotypes associated with the metabolic syndrome from 625 adult twin pairs of the GEMINAKAR study of the Danish Twin Registry. Results All endophenotypes showed moderate to high heritability (0.31-0.69) and small common environmental variance (0.05-0.21). In general, genetic and phenotypic correlations between the endophenotypes were strong only within sets of physiologically similar endophenotypes, but weak to moderate for other pairs of endophenotypes. However, moderate correlations between insulin resistance indices and either obesity-related endophenotypes or triacylglycerol levels indicated that some common genetic backgrounds are shared between those components. Conclusions/interpretation We demonstrated that, in a general population, the endophenotypes associated with the metabolic syndrome apparently do not share a substantial common genetic or familial environmental background. |
| doi_str_mv | 10.1007/s00125-007-0758-1 |
| format | Article |
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I. A ; Schousboe, K ; Fenger, M ; Visscher, P. M ; Kyvik, K. O</creator><creatorcontrib>Benyamin, B ; Sørensen, T. I. A ; Schousboe, K ; Fenger, M ; Visscher, P. M ; Kyvik, K. O</creatorcontrib><description>Aims/hypothesis The cluster of obesity, insulin resistance, dyslipidaemia and hypertension, called the metabolic syndrome, has been suggested as a risk factor for cardiovascular disease and type 2 diabetes. The aim of the present study was to evaluate whether there are common genetic and environmental factors influencing this cluster in a general population of twin pairs. Materials and methods A multivariate genetic analysis was performed on nine endophenotypes associated with the metabolic syndrome from 625 adult twin pairs of the GEMINAKAR study of the Danish Twin Registry. Results All endophenotypes showed moderate to high heritability (0.31-0.69) and small common environmental variance (0.05-0.21). In general, genetic and phenotypic correlations between the endophenotypes were strong only within sets of physiologically similar endophenotypes, but weak to moderate for other pairs of endophenotypes. However, moderate correlations between insulin resistance indices and either obesity-related endophenotypes or triacylglycerol levels indicated that some common genetic backgrounds are shared between those components. Conclusions/interpretation We demonstrated that, in a general population, the endophenotypes associated with the metabolic syndrome apparently do not share a substantial common genetic or familial environmental background.</description><identifier>ISSN: 0012-186X</identifier><identifier>EISSN: 1432-0428</identifier><identifier>DOI: 10.1007/s00125-007-0758-1</identifier><identifier>PMID: 17624514</identifier><language>eng</language><publisher>Berlin: Berlin/Heidelberg : Springer-Verlag</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Blood Pressure ; Body Mass Index ; Cardiovascular disease ; correlation ; Diabetes ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Environment ; Epidemiology ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; genetics ; Health care ; heritability ; Homeostasis ; Humans ; Hypertension ; Insulin resistance ; Insulin Resistance - genetics ; Insulin Resistance - physiology ; Lipids - blood ; Lipoproteins - blood ; Male ; Medical sciences ; Metabolic diseases ; Metabolic disorders ; Metabolic syndrome ; Metabolic Syndrome - etiology ; Metabolic Syndrome - genetics ; Middle Aged ; Miscellaneous ; Multivariate ; Obesity ; Obesity - genetics ; Obesity - physiopathology ; Other metabolic disorders ; Phenotype ; Twins ; Twins, Dizygotic ; Twins, Monozygotic</subject><ispartof>Diabetologia, 2007-09, Vol.50 (9), p.1880-1888</ispartof><rights>2007 INIST-CNRS</rights><rights>Springer-Verlag 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-2e03b1f080f91d7bff612be7f924804e5b7e5a956f94a1ed3cd915f9997faedf3</citedby><cites>FETCH-LOGICAL-c423t-2e03b1f080f91d7bff612be7f924804e5b7e5a956f94a1ed3cd915f9997faedf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18994153$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17624514$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Benyamin, B</creatorcontrib><creatorcontrib>Sørensen, T. I. A</creatorcontrib><creatorcontrib>Schousboe, K</creatorcontrib><creatorcontrib>Fenger, M</creatorcontrib><creatorcontrib>Visscher, P. M</creatorcontrib><creatorcontrib>Kyvik, K. O</creatorcontrib><title>Are there common genetic and environmental factors behind the endophenotypes associated with the metabolic syndrome</title><title>Diabetologia</title><addtitle>Diabetologia</addtitle><description>Aims/hypothesis The cluster of obesity, insulin resistance, dyslipidaemia and hypertension, called the metabolic syndrome, has been suggested as a risk factor for cardiovascular disease and type 2 diabetes. The aim of the present study was to evaluate whether there are common genetic and environmental factors influencing this cluster in a general population of twin pairs. Materials and methods A multivariate genetic analysis was performed on nine endophenotypes associated with the metabolic syndrome from 625 adult twin pairs of the GEMINAKAR study of the Danish Twin Registry. Results All endophenotypes showed moderate to high heritability (0.31-0.69) and small common environmental variance (0.05-0.21). In general, genetic and phenotypic correlations between the endophenotypes were strong only within sets of physiologically similar endophenotypes, but weak to moderate for other pairs of endophenotypes. However, moderate correlations between insulin resistance indices and either obesity-related endophenotypes or triacylglycerol levels indicated that some common genetic backgrounds are shared between those components. Conclusions/interpretation We demonstrated that, in a general population, the endophenotypes associated with the metabolic syndrome apparently do not share a substantial common genetic or familial environmental background.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure</subject><subject>Body Mass Index</subject><subject>Cardiovascular disease</subject><subject>correlation</subject><subject>Diabetes</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Environment</subject><subject>Epidemiology</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>genetics</subject><subject>Health care</subject><subject>heritability</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Insulin resistance</subject><subject>Insulin Resistance - genetics</subject><subject>Insulin Resistance - physiology</subject><subject>Lipids - blood</subject><subject>Lipoproteins - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Metabolic disorders</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - etiology</subject><subject>Metabolic Syndrome - genetics</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Multivariate</subject><subject>Obesity</subject><subject>Obesity - genetics</subject><subject>Obesity - physiopathology</subject><subject>Other metabolic disorders</subject><subject>Phenotype</subject><subject>Twins</subject><subject>Twins, Dizygotic</subject><subject>Twins, Monozygotic</subject><issn>0012-186X</issn><issn>1432-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpd0UuLFDEQAOAgijuu_gAv2gh6a03l1Z3jsviCBQ-64C2kk8pOL93JmGSU-fdmnIEFL0lBfVUVUoS8BPoeKB0-FEqByb6FPR3k2MMjsgHBWU8FGx-TzTHdw6h-XpBnpdxTSrkU6im5gEExIUFsSLnK2NUtttOldU2xu8OIdXadjb7D-HvOKa4Yq126YF1NuXQTbueWbFUN-LTbYkz1sMPS2VKSm21F3_2Z6_YfWbHaKS2tYzlEn9OKz8mTYJeCL873Jbn99PHH9Zf-5tvnr9dXN70TjNeeIeUTBDrSoMEPUwgK2IRD0EyMVKCcBpRWSxW0sICeO69BBq31ECz6wC_Ju1PfXU6_9liqWeficFlsxLQvRo3AR8p0g2_-g_dpn2N7m2GNCKUYawhOyOVUSsZgdnlebT4YoOa4DnNahzmGx3UYaDWvzo3304r-oeL8_w28PQNbnF1CttHN5cGNWguQvLnXJxdsMvYuN3P7nVHgbZhWQBn_CxCNnbE</recordid><startdate>20070901</startdate><enddate>20070901</enddate><creator>Benyamin, B</creator><creator>Sørensen, T. 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I. A ; Schousboe, K ; Fenger, M ; Visscher, P. M ; Kyvik, K. O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-2e03b1f080f91d7bff612be7f924804e5b7e5a956f94a1ed3cd915f9997faedf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure</topic><topic>Body Mass Index</topic><topic>Cardiovascular disease</topic><topic>correlation</topic><topic>Diabetes</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Environment</topic><topic>Epidemiology</topic><topic>Etiopathogenesis. Screening. Investigations. 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Materials and methods A multivariate genetic analysis was performed on nine endophenotypes associated with the metabolic syndrome from 625 adult twin pairs of the GEMINAKAR study of the Danish Twin Registry. Results All endophenotypes showed moderate to high heritability (0.31-0.69) and small common environmental variance (0.05-0.21). In general, genetic and phenotypic correlations between the endophenotypes were strong only within sets of physiologically similar endophenotypes, but weak to moderate for other pairs of endophenotypes. However, moderate correlations between insulin resistance indices and either obesity-related endophenotypes or triacylglycerol levels indicated that some common genetic backgrounds are shared between those components. 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| subjects | Adult Aged Biological and medical sciences Blood Pressure Body Mass Index Cardiovascular disease correlation Diabetes Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Environment Epidemiology Etiopathogenesis. Screening. Investigations. Target tissue resistance Female genetics Health care heritability Homeostasis Humans Hypertension Insulin resistance Insulin Resistance - genetics Insulin Resistance - physiology Lipids - blood Lipoproteins - blood Male Medical sciences Metabolic diseases Metabolic disorders Metabolic syndrome Metabolic Syndrome - etiology Metabolic Syndrome - genetics Middle Aged Miscellaneous Multivariate Obesity Obesity - genetics Obesity - physiopathology Other metabolic disorders Phenotype Twins Twins, Dizygotic Twins, Monozygotic |
| title | Are there common genetic and environmental factors behind the endophenotypes associated with the metabolic syndrome |
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