Splenic tuberculosis presenting as pyrexia of unknown origin
We report a case of a previously healthy 38-year old lady who presented with prolonged fever and hepatosplenomegaly. Intensive investigations were performed for pyrexia of unknown origin which revealed negative. CT scan of the abdomen showed multiple hypodense lesions which did not respond to broad-...
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| Veröffentlicht in: | Medical journal of Malaysia 2007-03, Vol.62 (1), p.70-71 |
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| container_end_page | 71 |
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| container_title | Medical journal of Malaysia |
| container_volume | 62 |
| creator | Hamizah, R Rohana, A G Anwar, S A Ong, T Z Hamzaini, A H Zulkarnaen, A N |
| description | We report a case of a previously healthy 38-year old lady who presented with prolonged fever and hepatosplenomegaly. Intensive investigations were performed for pyrexia of unknown origin which revealed negative. CT scan of the abdomen showed multiple hypodense lesions which did not respond to broad-spectrum antibiotics. Percutaneous biopsy of the splenic lesion revealed granuloma formation and Langhan's giant cells suggestive of TB. She responded well with anti- TB medication but required extended treatment duration of 24 months due to persistence of the splenic lesion on repeated CT scans. This case illustrates a very rare clinical entity of isolated splenic TB with a therapeutic dilemma following incomplete resolution, despite prolonged treatment. |
| format | Article |
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Intensive investigations were performed for pyrexia of unknown origin which revealed negative. CT scan of the abdomen showed multiple hypodense lesions which did not respond to broad-spectrum antibiotics. Percutaneous biopsy of the splenic lesion revealed granuloma formation and Langhan's giant cells suggestive of TB. She responded well with anti- TB medication but required extended treatment duration of 24 months due to persistence of the splenic lesion on repeated CT scans. 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Intensive investigations were performed for pyrexia of unknown origin which revealed negative. CT scan of the abdomen showed multiple hypodense lesions which did not respond to broad-spectrum antibiotics. Percutaneous biopsy of the splenic lesion revealed granuloma formation and Langhan's giant cells suggestive of TB. She responded well with anti- TB medication but required extended treatment duration of 24 months due to persistence of the splenic lesion on repeated CT scans. This case illustrates a very rare clinical entity of isolated splenic TB with a therapeutic dilemma following incomplete resolution, despite prolonged treatment.</description><subject>Adult</subject><subject>Antitubercular Agents - therapeutic use</subject><subject>Female</subject><subject>Fever of Unknown Origin - etiology</subject><subject>Humans</subject><subject>Malaysia</subject><subject>Tomography, X-Ray Computed</subject><subject>Tuberculosis, Splenic - drug therapy</subject><subject>Tuberculosis, Splenic - physiopathology</subject><issn>0300-5283</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1TztrwzAY1NCShDR_oWjqZpD0RbINXUroCwId2sxGsj4HtbbkShZt_n0NTW65B8fBXZEVA8YKKSpYkk1Kn2yGknOoFmTJS1UJWZYrcv8-9uhdS6dsMLa5D8klOkZM6Cfnj1TP7hTx12kaOpr9lw8_nobojs7fkOtO9wk3Z16Tw9Pjx-6l2L89v-4e9sXIxXYqbMdBgjZsi2bWNTPWMltbWQO00pjWKqmxVFxzLjR2smKAgEwAVsyAgjW5-98dY_jOmKZmcKnFvtceQ06NqjiUIGAu3p6L2QxomzG6QcdTc_kLf6NhUgE</recordid><startdate>200703</startdate><enddate>200703</enddate><creator>Hamizah, R</creator><creator>Rohana, A G</creator><creator>Anwar, S A</creator><creator>Ong, T Z</creator><creator>Hamzaini, A H</creator><creator>Zulkarnaen, A N</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200703</creationdate><title>Splenic tuberculosis presenting as pyrexia of unknown origin</title><author>Hamizah, R ; Rohana, A G ; Anwar, S A ; Ong, T Z ; Hamzaini, A H ; Zulkarnaen, A N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p124t-df1353ab04ebdf190bdd0d9d5933c5bbcd65ae761a112aef5803e3e023e80b363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Antitubercular Agents - therapeutic use</topic><topic>Female</topic><topic>Fever of Unknown Origin - etiology</topic><topic>Humans</topic><topic>Malaysia</topic><topic>Tomography, X-Ray Computed</topic><topic>Tuberculosis, Splenic - drug therapy</topic><topic>Tuberculosis, Splenic - physiopathology</topic><toplevel>online_resources</toplevel><creatorcontrib>Hamizah, R</creatorcontrib><creatorcontrib>Rohana, A G</creatorcontrib><creatorcontrib>Anwar, S A</creatorcontrib><creatorcontrib>Ong, T Z</creatorcontrib><creatorcontrib>Hamzaini, A H</creatorcontrib><creatorcontrib>Zulkarnaen, A N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Medical journal of Malaysia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hamizah, R</au><au>Rohana, A G</au><au>Anwar, S A</au><au>Ong, T Z</au><au>Hamzaini, A H</au><au>Zulkarnaen, A N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Splenic tuberculosis presenting as pyrexia of unknown origin</atitle><jtitle>Medical journal of Malaysia</jtitle><addtitle>Med J Malaysia</addtitle><date>2007-03</date><risdate>2007</risdate><volume>62</volume><issue>1</issue><spage>70</spage><epage>71</epage><pages>70-71</pages><issn>0300-5283</issn><abstract>We report a case of a previously healthy 38-year old lady who presented with prolonged fever and hepatosplenomegaly. 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| fulltext | fulltext |
| identifier | ISSN: 0300-5283 |
| ispartof | Medical journal of Malaysia, 2007-03, Vol.62 (1), p.70-71 |
| issn | 0300-5283 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Antitubercular Agents - therapeutic use Female Fever of Unknown Origin - etiology Humans Malaysia Tomography, X-Ray Computed Tuberculosis, Splenic - drug therapy Tuberculosis, Splenic - physiopathology |
| title | Splenic tuberculosis presenting as pyrexia of unknown origin |
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