Electroencephalographic and imaging profile in a subacute sclerosing panencephalitis (SSPE) cohort: A correlative study
Abstract Objective There are only a few studies correlating diverse radiological and EEG features of subacute sclerosing panencephalitis (SSPE). The objective of the study was to (a) describe EEG profile and (b) correlate it with the clinical and imaging data of patients with confirmed SSPE. Methods...
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| Veröffentlicht in: | Clinical neurophysiology 2007-09, Vol.118 (9), p.1947-1954 |
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| creator | Praveen-kumar, S Sinha, S Taly, A.B Jayasree, S Ravi, V Vijayan, J Ravishankar, S |
| description | Abstract Objective There are only a few studies correlating diverse radiological and EEG features of subacute sclerosing panencephalitis (SSPE). The objective of the study was to (a) describe EEG profile and (b) correlate it with the clinical and imaging data of patients with confirmed SSPE. Methods This study was conducted at a University teaching hospital in south India and involved 58 patients (M:F = 37:21, age: 12.3, SD 4.8 years) of SSPE. Diagnosis of SSPE was based on the characteristic clinical manifestations, and raised IgG (⩾1:625) anti-measles antibody in cerebrospinal fluid (CSF) by ELISA in all the patients. Scalp EEGs were recorded on 16 channel machines using standard parameters and procedures. The EEG, clinical and imaging data were reviewed. Results EEGs were frequently abnormal: typical (37) and atypical (21). Diffuse slowing of background activity (BGA) was noted in 46 records being asymmetrical in six. Periodic complexes were periodic (32), quasi-periodic (21) or a-periodic (4). Periodic complexes (PC) (amplitude: 370.7, SD 171.2 μV; duration – 1.7, SD 2.0 s; inter-complex interval: 8.4, SD 9.2 s) were symmetrical in 39 and asymmetrical in 19. CT (32) and MRI (23) scans were normal in 16 patients while others had white matter (15), cerebral edema (8), cerebral atrophy (8), basal ganglia (2), and thalamic (2) changes. There was an independent association of frontally dominant slowing of BGA ( p = 0.04) and typical PCs ( p = 0.03) with the diffuse cerebral edema on imaging. White matter changes correlated with slowing of BGA ( p = 0.04), but not with typical PC ( p = 0.16). Conclusions This study provides valuable insight into the structural and clinical correlates of EEG changes in SSPE. Significance Irrespective of the incidence of occurrence of SSPE in a community, a clinician should be aware of the wide spectra of EEG findings. This study also discusses the possible underlying structural and clinical correlates. |
| doi_str_mv | 10.1016/j.clinph.2007.06.008 |
| format | Article |
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The objective of the study was to (a) describe EEG profile and (b) correlate it with the clinical and imaging data of patients with confirmed SSPE. Methods This study was conducted at a University teaching hospital in south India and involved 58 patients (M:F = 37:21, age: 12.3, SD 4.8 years) of SSPE. Diagnosis of SSPE was based on the characteristic clinical manifestations, and raised IgG (⩾1:625) anti-measles antibody in cerebrospinal fluid (CSF) by ELISA in all the patients. Scalp EEGs were recorded on 16 channel machines using standard parameters and procedures. The EEG, clinical and imaging data were reviewed. Results EEGs were frequently abnormal: typical (37) and atypical (21). Diffuse slowing of background activity (BGA) was noted in 46 records being asymmetrical in six. Periodic complexes were periodic (32), quasi-periodic (21) or a-periodic (4). Periodic complexes (PC) (amplitude: 370.7, SD 171.2 μV; duration – 1.7, SD 2.0 s; inter-complex interval: 8.4, SD 9.2 s) were symmetrical in 39 and asymmetrical in 19. CT (32) and MRI (23) scans were normal in 16 patients while others had white matter (15), cerebral edema (8), cerebral atrophy (8), basal ganglia (2), and thalamic (2) changes. There was an independent association of frontally dominant slowing of BGA ( p = 0.04) and typical PCs ( p = 0.03) with the diffuse cerebral edema on imaging. White matter changes correlated with slowing of BGA ( p = 0.04), but not with typical PC ( p = 0.16). Conclusions This study provides valuable insight into the structural and clinical correlates of EEG changes in SSPE. Significance Irrespective of the incidence of occurrence of SSPE in a community, a clinician should be aware of the wide spectra of EEG findings. This study also discusses the possible underlying structural and clinical correlates.</description><identifier>ISSN: 1388-2457</identifier><identifier>EISSN: 1872-8952</identifier><identifier>DOI: 10.1016/j.clinph.2007.06.008</identifier><identifier>PMID: 17652019</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adolescent ; Atrophy ; Biological and medical sciences ; Brain - diagnostic imaging ; Brain - pathology ; Brain - physiopathology ; Brain Edema - etiology ; Child ; Cohort Studies ; EEG ; Electrodiagnosis. Electric activity recording ; Electroencephalography ; Female ; Fundamental and applied biological sciences. Psychology ; General aspects. Models. Methods ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Imaging ; Male ; Medical sciences ; MRI ; Nervous system ; Neurology ; Periodic complexes ; Periodicity ; SSPE ; Subacute Sclerosing Panencephalitis - complications ; Subacute Sclerosing Panencephalitis - diagnosis ; Subacute Sclerosing Panencephalitis - physiopathology ; Tomography, X-Ray Computed ; Vertebrates: nervous system and sense organs</subject><ispartof>Clinical neurophysiology, 2007-09, Vol.118 (9), p.1947-1954</ispartof><rights>International Federation of Clinical Neurophysiology</rights><rights>2007 International Federation of Clinical Neurophysiology</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-10373814691f6d51bb739d9f7afc6a473002b4d2c3319c8e87e2d3fd11e31fc63</citedby><cites>FETCH-LOGICAL-c445t-10373814691f6d51bb739d9f7afc6a473002b4d2c3319c8e87e2d3fd11e31fc63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clinph.2007.06.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18996829$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17652019$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Praveen-kumar, S</creatorcontrib><creatorcontrib>Sinha, S</creatorcontrib><creatorcontrib>Taly, A.B</creatorcontrib><creatorcontrib>Jayasree, S</creatorcontrib><creatorcontrib>Ravi, V</creatorcontrib><creatorcontrib>Vijayan, J</creatorcontrib><creatorcontrib>Ravishankar, S</creatorcontrib><title>Electroencephalographic and imaging profile in a subacute sclerosing panencephalitis (SSPE) cohort: A correlative study</title><title>Clinical neurophysiology</title><addtitle>Clin Neurophysiol</addtitle><description>Abstract Objective There are only a few studies correlating diverse radiological and EEG features of subacute sclerosing panencephalitis (SSPE). The objective of the study was to (a) describe EEG profile and (b) correlate it with the clinical and imaging data of patients with confirmed SSPE. Methods This study was conducted at a University teaching hospital in south India and involved 58 patients (M:F = 37:21, age: 12.3, SD 4.8 years) of SSPE. Diagnosis of SSPE was based on the characteristic clinical manifestations, and raised IgG (⩾1:625) anti-measles antibody in cerebrospinal fluid (CSF) by ELISA in all the patients. Scalp EEGs were recorded on 16 channel machines using standard parameters and procedures. The EEG, clinical and imaging data were reviewed. Results EEGs were frequently abnormal: typical (37) and atypical (21). Diffuse slowing of background activity (BGA) was noted in 46 records being asymmetrical in six. Periodic complexes were periodic (32), quasi-periodic (21) or a-periodic (4). Periodic complexes (PC) (amplitude: 370.7, SD 171.2 μV; duration – 1.7, SD 2.0 s; inter-complex interval: 8.4, SD 9.2 s) were symmetrical in 39 and asymmetrical in 19. CT (32) and MRI (23) scans were normal in 16 patients while others had white matter (15), cerebral edema (8), cerebral atrophy (8), basal ganglia (2), and thalamic (2) changes. There was an independent association of frontally dominant slowing of BGA ( p = 0.04) and typical PCs ( p = 0.03) with the diffuse cerebral edema on imaging. White matter changes correlated with slowing of BGA ( p = 0.04), but not with typical PC ( p = 0.16). Conclusions This study provides valuable insight into the structural and clinical correlates of EEG changes in SSPE. Significance Irrespective of the incidence of occurrence of SSPE in a community, a clinician should be aware of the wide spectra of EEG findings. This study also discusses the possible underlying structural and clinical correlates.</description><subject>Adolescent</subject><subject>Atrophy</subject><subject>Biological and medical sciences</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - pathology</subject><subject>Brain - physiopathology</subject><subject>Brain Edema - etiology</subject><subject>Child</subject><subject>Cohort Studies</subject><subject>EEG</subject><subject>Electrodiagnosis. Electric activity recording</subject><subject>Electroencephalography</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects. Models. Methods</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>MRI</subject><subject>Nervous system</subject><subject>Neurology</subject><subject>Periodic complexes</subject><subject>Periodicity</subject><subject>SSPE</subject><subject>Subacute Sclerosing Panencephalitis - complications</subject><subject>Subacute Sclerosing Panencephalitis - diagnosis</subject><subject>Subacute Sclerosing Panencephalitis - physiopathology</subject><subject>Tomography, X-Ray Computed</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>1388-2457</issn><issn>1872-8952</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1v1DAQhi0EoqXwDxDyBQSHBH8kscMBqaqWUqkSSAtny7Enu168cbCTov33OOxWlbj05Dk889rzeBB6TUlJCW0-7krj3TBuS0aIKElTEiKfoHMqBStkW7OnueZSFqyqxRl6kdKOZJBU7Dk6o6KpGaHtOfqz8mCmGGAwMG61D5uox60zWA8Wu73euGGDxxh65wG7AWuc5k6beQKcjIcY0j9AD_cBbnIJv1-vv68-YBO2IU6f8GWuYgSvJ3eX-6bZHl6iZ732CV6dzgv088vqx9XX4vbb9c3V5W1hqqqeCkq44JJWTUv7xta06wRvbdsL3ZtGV4ITwrrKMsM5bY0EKYBZ3ltKgdOM8Av07pibZ_g9Q5rU3iUD3ucXhzmpRlIuGGMZrI6gyTOlCL0aY54_HhQlahGuduooXC3CFWlUFp7b3pzy524P9qHpZDgDb0-ATkb7PurBuPTAybZtJFu4z0cOso07B1El4xap1sX8Q8oG99hL_g9YIJfv_AUHSLswxyGbVlQlpohaL8ux7EbeCcJayfhfYqG2jQ</recordid><startdate>20070901</startdate><enddate>20070901</enddate><creator>Praveen-kumar, S</creator><creator>Sinha, S</creator><creator>Taly, A.B</creator><creator>Jayasree, S</creator><creator>Ravi, V</creator><creator>Vijayan, J</creator><creator>Ravishankar, S</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070901</creationdate><title>Electroencephalographic and imaging profile in a subacute sclerosing panencephalitis (SSPE) cohort: A correlative study</title><author>Praveen-kumar, S ; Sinha, S ; Taly, A.B ; Jayasree, S ; Ravi, V ; Vijayan, J ; Ravishankar, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-10373814691f6d51bb739d9f7afc6a473002b4d2c3319c8e87e2d3fd11e31fc63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Atrophy</topic><topic>Biological and medical sciences</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - pathology</topic><topic>Brain - physiopathology</topic><topic>Brain Edema - etiology</topic><topic>Child</topic><topic>Cohort Studies</topic><topic>EEG</topic><topic>Electrodiagnosis. Electric activity recording</topic><topic>Electroencephalography</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects. Models. Methods</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>MRI</topic><topic>Nervous system</topic><topic>Neurology</topic><topic>Periodic complexes</topic><topic>Periodicity</topic><topic>SSPE</topic><topic>Subacute Sclerosing Panencephalitis - complications</topic><topic>Subacute Sclerosing Panencephalitis - diagnosis</topic><topic>Subacute Sclerosing Panencephalitis - physiopathology</topic><topic>Tomography, X-Ray Computed</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Praveen-kumar, S</creatorcontrib><creatorcontrib>Sinha, S</creatorcontrib><creatorcontrib>Taly, A.B</creatorcontrib><creatorcontrib>Jayasree, S</creatorcontrib><creatorcontrib>Ravi, V</creatorcontrib><creatorcontrib>Vijayan, J</creatorcontrib><creatorcontrib>Ravishankar, S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical neurophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Praveen-kumar, S</au><au>Sinha, S</au><au>Taly, A.B</au><au>Jayasree, S</au><au>Ravi, V</au><au>Vijayan, J</au><au>Ravishankar, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Electroencephalographic and imaging profile in a subacute sclerosing panencephalitis (SSPE) cohort: A correlative study</atitle><jtitle>Clinical neurophysiology</jtitle><addtitle>Clin Neurophysiol</addtitle><date>2007-09-01</date><risdate>2007</risdate><volume>118</volume><issue>9</issue><spage>1947</spage><epage>1954</epage><pages>1947-1954</pages><issn>1388-2457</issn><eissn>1872-8952</eissn><abstract>Abstract Objective There are only a few studies correlating diverse radiological and EEG features of subacute sclerosing panencephalitis (SSPE). The objective of the study was to (a) describe EEG profile and (b) correlate it with the clinical and imaging data of patients with confirmed SSPE. Methods This study was conducted at a University teaching hospital in south India and involved 58 patients (M:F = 37:21, age: 12.3, SD 4.8 years) of SSPE. Diagnosis of SSPE was based on the characteristic clinical manifestations, and raised IgG (⩾1:625) anti-measles antibody in cerebrospinal fluid (CSF) by ELISA in all the patients. Scalp EEGs were recorded on 16 channel machines using standard parameters and procedures. The EEG, clinical and imaging data were reviewed. Results EEGs were frequently abnormal: typical (37) and atypical (21). Diffuse slowing of background activity (BGA) was noted in 46 records being asymmetrical in six. Periodic complexes were periodic (32), quasi-periodic (21) or a-periodic (4). Periodic complexes (PC) (amplitude: 370.7, SD 171.2 μV; duration – 1.7, SD 2.0 s; inter-complex interval: 8.4, SD 9.2 s) were symmetrical in 39 and asymmetrical in 19. CT (32) and MRI (23) scans were normal in 16 patients while others had white matter (15), cerebral edema (8), cerebral atrophy (8), basal ganglia (2), and thalamic (2) changes. There was an independent association of frontally dominant slowing of BGA ( p = 0.04) and typical PCs ( p = 0.03) with the diffuse cerebral edema on imaging. White matter changes correlated with slowing of BGA ( p = 0.04), but not with typical PC ( p = 0.16). Conclusions This study provides valuable insight into the structural and clinical correlates of EEG changes in SSPE. Significance Irrespective of the incidence of occurrence of SSPE in a community, a clinician should be aware of the wide spectra of EEG findings. This study also discusses the possible underlying structural and clinical correlates.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>17652019</pmid><doi>10.1016/j.clinph.2007.06.008</doi><tpages>8</tpages></addata></record> |
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| subjects | Adolescent Atrophy Biological and medical sciences Brain - diagnostic imaging Brain - pathology Brain - physiopathology Brain Edema - etiology Child Cohort Studies EEG Electrodiagnosis. Electric activity recording Electroencephalography Female Fundamental and applied biological sciences. Psychology General aspects. Models. Methods Humans Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging Male Medical sciences MRI Nervous system Neurology Periodic complexes Periodicity SSPE Subacute Sclerosing Panencephalitis - complications Subacute Sclerosing Panencephalitis - diagnosis Subacute Sclerosing Panencephalitis - physiopathology Tomography, X-Ray Computed Vertebrates: nervous system and sense organs |
| title | Electroencephalographic and imaging profile in a subacute sclerosing panencephalitis (SSPE) cohort: A correlative study |
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