Prenatal cocaine and morphine alter brain cyclin-dependent kinase 5 (Cdk5) activity in rat pups
Pregnant rats received daily injections of saline, cocaine (20 mg/kg), morphine (2 mg/kg), or the combination of both drugs, on days 13–20 of gestation. Cyclin-dependent kinase 5 (Cdk5) activity was then measured in the resulting pups on postnatal days 1, 7, 14 and 28. Cocaine resulted in a time dep...
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| Veröffentlicht in: | Neurotoxicology and teratology 2006-09, Vol.28 (5), p.625-628 |
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| creator | Bhat, Rama Chari, Gopal Rao, Ravi Wirtshafter, David |
| description | Pregnant rats received daily injections of saline, cocaine (20 mg/kg), morphine (2 mg/kg), or the combination of both drugs, on days 13–20 of gestation. Cyclin-dependent kinase 5 (Cdk5) activity was then measured in the resulting pups on postnatal days 1, 7, 14 and 28. Cocaine resulted in a time dependent increase in brain Cdk5 activity which peaked on day 14. Morphine, in contrast, induced a decrease in Cdk5 activity which was also maximal on day 14. Combined administration of the two drugs led to smaller increases than those seen after cocaine alone. These findings demonstrate that prenatal drug exposure can modify postnatal activity of Cdk5 in the brain and raise the possibility that alterations in Cdk5 may play a role in some of the neural and behavioral effects produced by these treatments. |
| doi_str_mv | 10.1016/j.ntt.2006.06.006 |
| format | Article |
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Cyclin-dependent kinase 5 (Cdk5) activity was then measured in the resulting pups on postnatal days 1, 7, 14 and 28. Cocaine resulted in a time dependent increase in brain Cdk5 activity which peaked on day 14. Morphine, in contrast, induced a decrease in Cdk5 activity which was also maximal on day 14. Combined administration of the two drugs led to smaller increases than those seen after cocaine alone. 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Cyclin-dependent kinase 5 (Cdk5) activity was then measured in the resulting pups on postnatal days 1, 7, 14 and 28. Cocaine resulted in a time dependent increase in brain Cdk5 activity which peaked on day 14. Morphine, in contrast, induced a decrease in Cdk5 activity which was also maximal on day 14. Combined administration of the two drugs led to smaller increases than those seen after cocaine alone. These findings demonstrate that prenatal drug exposure can modify postnatal activity of Cdk5 in the brain and raise the possibility that alterations in Cdk5 may play a role in some of the neural and behavioral effects produced by these treatments.</description><subject>Addictive behaviors</subject><subject>Adult and adolescent clinical studies</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Biological and medical sciences</subject><subject>Blotting, Western - methods</subject><subject>Brain - drug effects</subject><subject>Brain - enzymology</subject><subject>Brain development</subject><subject>Cdk5</subject><subject>Cocaine - pharmacology</subject><subject>Cyclin-Dependent Kinase 5 - metabolism</subject><subject>Dopamine</subject><subject>Drug abuse</subject><subject>Drug addiction</subject><subject>Drug addictions</subject><subject>Female</subject><subject>Medical sciences</subject><subject>Morphine - pharmacology</subject><subject>Neuroteratology</subject><subject>Neurotoxology</subject><subject>Opioids</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects - enzymology</subject><subject>Prenatal Exposure Delayed Effects - pathology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Toxicology</subject><issn>0892-0362</issn><issn>1872-9738</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM2KFDEUhYMoTjv6AG4kG0UX1d4klZ9iVtL4BwO60HVIJbcwPdWpMkkP9NtbZTfMTuFAyL1fDuEj5CWDLQOm3u-3qdYtB1DbNaAekQ0zmjedFuYx2YDpeANC8SvyrJQ9AGjF4Cm5YqpTXLewIfZ7xuSqG6mfvIsJqUuBHqY8__p7GStm2udlQ_3JjzE1AWdMAVOldzG5glTSt7twJ99R52u8j_VEFzi7SufjXJ6TJ4MbC764nNfk56ePP3Zfmttvn7_uPtw2vmW8NobhwJgELr0bgGuhpQy6l751Wvplgg4NDL4H07dKoQQPQgwOlA697npxTd6ce-c8_T5iqfYQi8dxdAmnY7HKMKGZUf8FWSeZ4q1eQHYGfZ5KyTjYOceDyyfLwK767d4u-u2q366BtfzVpfzYHzA8vLj4XoDXF8AV78Yhu-RjeeCMAKFFu3A3Zw4XZ_cRsy0-YvIYYkZfbZjiP77xB0nQoeo</recordid><startdate>20060901</startdate><enddate>20060901</enddate><creator>Bhat, Rama</creator><creator>Chari, Gopal</creator><creator>Rao, Ravi</creator><creator>Wirtshafter, David</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20060901</creationdate><title>Prenatal cocaine and morphine alter brain cyclin-dependent kinase 5 (Cdk5) activity in rat pups</title><author>Bhat, Rama ; Chari, Gopal ; Rao, Ravi ; Wirtshafter, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-81ef115025caf0273755d7b5c4a75cf02eae80fcb08b466e50c033fa067db79b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Addictive behaviors</topic><topic>Adult and adolescent clinical studies</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Biological and medical sciences</topic><topic>Blotting, Western - methods</topic><topic>Brain - drug effects</topic><topic>Brain - enzymology</topic><topic>Brain development</topic><topic>Cdk5</topic><topic>Cocaine - pharmacology</topic><topic>Cyclin-Dependent Kinase 5 - metabolism</topic><topic>Dopamine</topic><topic>Drug abuse</topic><topic>Drug addiction</topic><topic>Drug addictions</topic><topic>Female</topic><topic>Medical sciences</topic><topic>Morphine - pharmacology</topic><topic>Neuroteratology</topic><topic>Neurotoxology</topic><topic>Opioids</topic><topic>Pregnancy</topic><topic>Prenatal Exposure Delayed Effects - enzymology</topic><topic>Prenatal Exposure Delayed Effects - pathology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. 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Cyclin-dependent kinase 5 (Cdk5) activity was then measured in the resulting pups on postnatal days 1, 7, 14 and 28. Cocaine resulted in a time dependent increase in brain Cdk5 activity which peaked on day 14. Morphine, in contrast, induced a decrease in Cdk5 activity which was also maximal on day 14. Combined administration of the two drugs led to smaller increases than those seen after cocaine alone. These findings demonstrate that prenatal drug exposure can modify postnatal activity of Cdk5 in the brain and raise the possibility that alterations in Cdk5 may play a role in some of the neural and behavioral effects produced by these treatments.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>16962740</pmid><doi>10.1016/j.ntt.2006.06.006</doi><tpages>4</tpages></addata></record> |
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| subjects | Addictive behaviors Adult and adolescent clinical studies Animals Animals, Newborn Biological and medical sciences Blotting, Western - methods Brain - drug effects Brain - enzymology Brain development Cdk5 Cocaine - pharmacology Cyclin-Dependent Kinase 5 - metabolism Dopamine Drug abuse Drug addiction Drug addictions Female Medical sciences Morphine - pharmacology Neuroteratology Neurotoxology Opioids Pregnancy Prenatal Exposure Delayed Effects - enzymology Prenatal Exposure Delayed Effects - pathology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Rats Rats, Sprague-Dawley Toxicology |
| title | Prenatal cocaine and morphine alter brain cyclin-dependent kinase 5 (Cdk5) activity in rat pups |
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