Protein profiling of rat ventral prostate following chronic finasteride administration: identification and localization of a novel putative androgen-regulated protein

To better understand the effects of antiandrogens on the prostate, we investigated the changes in the proteome of rat ventral prostate (VP) following treatment with a well characterized 5alpha-reductase inhibitor, finasteride. Sprague-Dawley rats were treated daily by gavage with finasteride at 0, 1...

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Veröffentlicht in:	Molecular & cellular proteomics 2006-11, Vol.5 (11), p.2031-2043
Hauptverfasser:	Cayatte, Corinne, Pons, Catherine, Guigonis, Jean-Marie, Pizzol, Jérôme, Elies, Laetitia, Kennel, Philippe, Rouquié, David, Bars, Rémi, Rossi, Bernard, Samson, Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	5-alpha Reductase Inhibitors Animals Electrophoresis, Gel, Two-Dimensional Enzyme Inhibitors - administration & dosage Epithelial Cells - enzymology Finasteride - administration & dosage L-Amino Acid Oxidase - analysis L-Amino Acid Oxidase - metabolism Male Organ Size - drug effects Phosphorylation Prostate - cytology Prostate - drug effects Prostate - metabolism Protein Array Analysis Proteins - analysis Rats Rats, Sprague-Dawley Secretory Vesicles - enzymology Tyrosine - metabolism
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