A Balance of Lipid-Sensing Mechanisms in the Brain and Liver

A Balance of Lipid-Sensing Mechanisms in the Brain and Liver

Recent work has cast a spotlight on the brain as a nutrient-sensing organ that regulates the body's metabolic processes. Here we discuss the physiological and molecular mechanisms of brain lipid sensing and compare these mechanisms to liver lipid sensing. A direct comparison between the lipid-s...

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Veröffentlicht in:Cell metabolism 2007-08, Vol.6 (2), p.99-104
Hauptverfasser: Caspi, Liora, Wang, Penny Y.T., Lam, Tony K.T.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Brain - metabolism
Diabetes Mellitus - metabolism
Humans
Insulin - metabolism
Lipid Metabolism
Liver - metabolism
Models, Animal
Obesity - metabolism
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Zusammenfassung:Recent work has cast a spotlight on the brain as a nutrient-sensing organ that regulates the body's metabolic processes. Here we discuss the physiological and molecular mechanisms of brain lipid sensing and compare these mechanisms to liver lipid sensing. A direct comparison between the lipid-sensing mechanisms in the brain and liver reveals similar biochemical/molecular but opposing physiological mechanisms in operation. We propose that an imbalance between the lipid-sensing mechanisms in the brain and liver may contribute to obesity-associated type 2 diabetes.
ISSN:1550-4131
1932-7420
DOI:10.1016/j.cmet.2007.07.005