Subtle metabolic and liver gene transcriptional changes underlie diet-induced fatty liver susceptibility in insulin-resistant mice

Complex changes in gene expression are associated with insulin resistance and non-alcoholic fatty liver disease (NAFLD) promoted by feeding a high-fat diet (HFD). We used functional genomic technologies to document molecular mechanisms associated with diet-induced NAFLD. Male 129S6 mice were fed a d...

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Veröffentlicht in:	Diabetologia 2007-09, Vol.50 (9), p.1867-1879
Hauptverfasser:	TOYE, A. A, DUMAS, M. E, BARTON, R. H, HOLMES, E, MCCARTHY, M. I, TATOUD, R, NICHOLSON, J. K, SCOTT, J, GAUGUIER, D, BLANCHER, C, ROTHWELL, A. R, FEARNSIDE, J. F, WILDER, S. P, BIHOREAU, M. T, CLOAREC, O, AZZOUZI, I, YOUNG, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Feed Animals Biological and medical sciences Carbohydrates Diabetes Diabetes. Impaired glucose tolerance Diet Dietary Fats Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fatty acids Fatty Liver - genetics Gastroenterology. Liver. Pancreas. Abdomen Gene expression Genetic Predisposition to Disease Genomes Glucose Glucose Tolerance Test Insulin - metabolism Insulin resistance Insulin Resistance - genetics Insulin Resistance - physiology Insulin Secretion Kinetics Lipids - blood Liver - physiology Liver diseases Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Metabolism Metabolites Mice Mice, Inbred BALB C Mice, Inbred Strains Obesity Other diseases. Semiology Oxidation Pathogenesis Plasma Sterols Transcription, Genetic
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