Improvement in Growth after Two Years of Growth Hormone Therapy in Very Young Children Born Small for Gestational Age and without Spontaneous Catch-Up Growth: Results of a Multicenter, Controlled, Randomized, Open Clinical Trial
Context: GH treatment is effective in children born small for gestational age (SGA); however, its effectiveness and safety in very young SGA children is unknown. Objective: The aim was to analyze the outcome of very young SGA children treated with GH and followed for 2 yr. The results after 24 month...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2007-08, Vol.92 (8), p.3095-3101 |
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| container_title | The journal of clinical endocrinology and metabolism |
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| creator | Argente, Jesús Gracia, Ricardo Ibáñez, Lourdes Oliver, Antonio Borrajo, Emilio Vela, Amaya López-Siguero, Juan Pedro Moreno, M. Llanos Rodríguez-Hierro, Francisco |
| description | Context: GH treatment is effective in children born small for gestational age (SGA); however, its effectiveness and safety in very young SGA children is unknown.
Objective: The aim was to analyze the outcome of very young SGA children treated with GH and followed for 2 yr. The results after 24 months of treatment, compared with a control group without treatment during 12 months followed by 12 months of treatment, are shown.
Design: We performed a multicenter, controlled, randomized, open trial.
Settings: The pediatric endocrinology departments of 14 public hospitals in Spain participated in the study.
Patients: Seventy-six children, aged 2–5 yr born SGA and without catch-up growth, were studied.
Intervention: Children received GH at 0.06 mg/kg·d for 2 yr (group I) or were followed for 12 months with no treatment and then treated for 12 months (group II).
Main Outcome Measures: Age, general health status, pubertal stage, bone age, height, weight, biochemical and hormonal analyses, and adverse side effects were determined at biannual check-ups.
Results: The mean height sd score gain for chronological age in children treated for 24 months (group I) was 2.10, whereas in those treated only during the last 12 months (group II) was 1.43. In both groups, children under 4 yr of age had the greatest gain in growth velocity. No significant acceleration of bone age or side effects related to treatment was seen.
Conclusion: Very young SGA children without spontaneous catch-up growth could benefit from GH treatment because growth was accelerated and no negative side effects were observed. |
| doi_str_mv | 10.1210/jc.2007-0078 |
| format | Article |
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Objective: The aim was to analyze the outcome of very young SGA children treated with GH and followed for 2 yr. The results after 24 months of treatment, compared with a control group without treatment during 12 months followed by 12 months of treatment, are shown.
Design: We performed a multicenter, controlled, randomized, open trial.
Settings: The pediatric endocrinology departments of 14 public hospitals in Spain participated in the study.
Patients: Seventy-six children, aged 2–5 yr born SGA and without catch-up growth, were studied.
Intervention: Children received GH at 0.06 mg/kg·d for 2 yr (group I) or were followed for 12 months with no treatment and then treated for 12 months (group II).
Main Outcome Measures: Age, general health status, pubertal stage, bone age, height, weight, biochemical and hormonal analyses, and adverse side effects were determined at biannual check-ups.
Results: The mean height sd score gain for chronological age in children treated for 24 months (group I) was 2.10, whereas in those treated only during the last 12 months (group II) was 1.43. In both groups, children under 4 yr of age had the greatest gain in growth velocity. No significant acceleration of bone age or side effects related to treatment was seen.
Conclusion: Very young SGA children without spontaneous catch-up growth could benefit from GH treatment because growth was accelerated and no negative side effects were observed.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2007-0078</identifier><identifier>PMID: 17536000</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Age Determination by Skeleton ; Anthropometry ; Biological and medical sciences ; Body Height - drug effects ; Body Mass Index ; Child, Preschool ; Endocrinopathies ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Growth - drug effects ; Growth Hormone - administration & dosage ; Growth Hormone - adverse effects ; Growth Hormone - therapeutic use ; Humans ; Infant, Newborn ; Infant, Small for Gestational Age - growth & development ; Insulin-Like Growth Factor Binding Protein 3 - metabolism ; Insulin-Like Growth Factor I - metabolism ; Male ; Medical sciences ; Parents ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: endocrinology</subject><ispartof>The journal of clinical endocrinology and metabolism, 2007-08, Vol.92 (8), p.3095-3101</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-d34c4968a41acaa2361567346cc23f6ad8270b7123285e4db0e25e69ff6859683</citedby><cites>FETCH-LOGICAL-c432t-d34c4968a41acaa2361567346cc23f6ad8270b7123285e4db0e25e69ff6859683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18997571$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17536000$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Argente, Jesús</creatorcontrib><creatorcontrib>Gracia, Ricardo</creatorcontrib><creatorcontrib>Ibáñez, Lourdes</creatorcontrib><creatorcontrib>Oliver, Antonio</creatorcontrib><creatorcontrib>Borrajo, Emilio</creatorcontrib><creatorcontrib>Vela, Amaya</creatorcontrib><creatorcontrib>López-Siguero, Juan Pedro</creatorcontrib><creatorcontrib>Moreno, M. Llanos</creatorcontrib><creatorcontrib>Rodríguez-Hierro, Francisco</creatorcontrib><creatorcontrib>Spanish SGA Working Group</creatorcontrib><title>Improvement in Growth after Two Years of Growth Hormone Therapy in Very Young Children Born Small for Gestational Age and without Spontaneous Catch-Up Growth: Results of a Multicenter, Controlled, Randomized, Open Clinical Trial</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Context: GH treatment is effective in children born small for gestational age (SGA); however, its effectiveness and safety in very young SGA children is unknown.
Objective: The aim was to analyze the outcome of very young SGA children treated with GH and followed for 2 yr. The results after 24 months of treatment, compared with a control group without treatment during 12 months followed by 12 months of treatment, are shown.
Design: We performed a multicenter, controlled, randomized, open trial.
Settings: The pediatric endocrinology departments of 14 public hospitals in Spain participated in the study.
Patients: Seventy-six children, aged 2–5 yr born SGA and without catch-up growth, were studied.
Intervention: Children received GH at 0.06 mg/kg·d for 2 yr (group I) or were followed for 12 months with no treatment and then treated for 12 months (group II).
Main Outcome Measures: Age, general health status, pubertal stage, bone age, height, weight, biochemical and hormonal analyses, and adverse side effects were determined at biannual check-ups.
Results: The mean height sd score gain for chronological age in children treated for 24 months (group I) was 2.10, whereas in those treated only during the last 12 months (group II) was 1.43. In both groups, children under 4 yr of age had the greatest gain in growth velocity. No significant acceleration of bone age or side effects related to treatment was seen.
Conclusion: Very young SGA children without spontaneous catch-up growth could benefit from GH treatment because growth was accelerated and no negative side effects were observed.</description><subject>Age Determination by Skeleton</subject><subject>Anthropometry</subject><subject>Biological and medical sciences</subject><subject>Body Height - drug effects</subject><subject>Body Mass Index</subject><subject>Child, Preschool</subject><subject>Endocrinopathies</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Growth - drug effects</subject><subject>Growth Hormone - administration & dosage</subject><subject>Growth Hormone - adverse effects</subject><subject>Growth Hormone - therapeutic use</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infant, Small for Gestational Age - growth & development</subject><subject>Insulin-Like Growth Factor Binding Protein 3 - metabolism</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Parents</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vertebrates: endocrinology</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhiMEokvhxhnNBU6b4o8kTriVCLaViiq1W0RPkdeZdL1y7GAnrJbfyw_Byy7qBYmD5ZHmmXln5k2S15ScUUbJ-406Y4SINL7ySTKjVZanglbiaTIjhNG0EuzbSfIihA0hNMty_jw5oSLnBSFklvy67AfvfmCPdgRtYeHddlyD7Eb0sNw6uEfpA7jub-bC-d5ZhOUavRx2-5qv6Hdw7yb7APVam9ajhY_OW7jtpTHQOQ8LDKMctbPSwPkDgrQtbPW4dtMIt4Ozo7TopgC1HNU6vRuOah_gBsNkxj8DSPgSQ63ipOjnUMcq74zBdg43sZ_r9c99fD1E-dpoq1UUW3otzcvkWSdNwFfH_zS5-_xpWV-kV9eLy_r8KlUZZ2Pa8kxlVVHKjEolJeMFzQvBs0IpxrtCtiUTZCUo46zMMWtXBFmORdV1RZnHOn6avDv0jSf9PsWVm14HhcYctmuKkvK8JPy_ICOsElSICM4PoPIuBI9dM3jdS79rKGn29jcb1eztb_b2R_zNse-06rF9hI9-R-DtEZAhnqfz0iodHrmyqkQuaOT4gcN4WOW1xcFjCM3GTT56GP4t_xuwnMvE</recordid><startdate>20070801</startdate><enddate>20070801</enddate><creator>Argente, Jesús</creator><creator>Gracia, Ricardo</creator><creator>Ibáñez, Lourdes</creator><creator>Oliver, Antonio</creator><creator>Borrajo, Emilio</creator><creator>Vela, Amaya</creator><creator>López-Siguero, Juan Pedro</creator><creator>Moreno, M. Llanos</creator><creator>Rodríguez-Hierro, Francisco</creator><general>Endocrine Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>20070801</creationdate><title>Improvement in Growth after Two Years of Growth Hormone Therapy in Very Young Children Born Small for Gestational Age and without Spontaneous Catch-Up Growth: Results of a Multicenter, Controlled, Randomized, Open Clinical Trial</title><author>Argente, Jesús ; Gracia, Ricardo ; Ibáñez, Lourdes ; Oliver, Antonio ; Borrajo, Emilio ; Vela, Amaya ; López-Siguero, Juan Pedro ; Moreno, M. Llanos ; Rodríguez-Hierro, Francisco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-d34c4968a41acaa2361567346cc23f6ad8270b7123285e4db0e25e69ff6859683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Age Determination by Skeleton</topic><topic>Anthropometry</topic><topic>Biological and medical sciences</topic><topic>Body Height - drug effects</topic><topic>Body Mass Index</topic><topic>Child, Preschool</topic><topic>Endocrinopathies</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Growth - drug effects</topic><topic>Growth Hormone - administration & dosage</topic><topic>Growth Hormone - adverse effects</topic><topic>Growth Hormone - therapeutic use</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infant, Small for Gestational Age - growth & development</topic><topic>Insulin-Like Growth Factor Binding Protein 3 - metabolism</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Parents</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Argente, Jesús</creatorcontrib><creatorcontrib>Gracia, Ricardo</creatorcontrib><creatorcontrib>Ibáñez, Lourdes</creatorcontrib><creatorcontrib>Oliver, Antonio</creatorcontrib><creatorcontrib>Borrajo, Emilio</creatorcontrib><creatorcontrib>Vela, Amaya</creatorcontrib><creatorcontrib>López-Siguero, Juan Pedro</creatorcontrib><creatorcontrib>Moreno, M. Llanos</creatorcontrib><creatorcontrib>Rodríguez-Hierro, Francisco</creatorcontrib><creatorcontrib>Spanish SGA Working Group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Argente, Jesús</au><au>Gracia, Ricardo</au><au>Ibáñez, Lourdes</au><au>Oliver, Antonio</au><au>Borrajo, Emilio</au><au>Vela, Amaya</au><au>López-Siguero, Juan Pedro</au><au>Moreno, M. Llanos</au><au>Rodríguez-Hierro, Francisco</au><aucorp>Spanish SGA Working Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improvement in Growth after Two Years of Growth Hormone Therapy in Very Young Children Born Small for Gestational Age and without Spontaneous Catch-Up Growth: Results of a Multicenter, Controlled, Randomized, Open Clinical Trial</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2007-08-01</date><risdate>2007</risdate><volume>92</volume><issue>8</issue><spage>3095</spage><epage>3101</epage><pages>3095-3101</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>Context: GH treatment is effective in children born small for gestational age (SGA); however, its effectiveness and safety in very young SGA children is unknown.
Objective: The aim was to analyze the outcome of very young SGA children treated with GH and followed for 2 yr. The results after 24 months of treatment, compared with a control group without treatment during 12 months followed by 12 months of treatment, are shown.
Design: We performed a multicenter, controlled, randomized, open trial.
Settings: The pediatric endocrinology departments of 14 public hospitals in Spain participated in the study.
Patients: Seventy-six children, aged 2–5 yr born SGA and without catch-up growth, were studied.
Intervention: Children received GH at 0.06 mg/kg·d for 2 yr (group I) or were followed for 12 months with no treatment and then treated for 12 months (group II).
Main Outcome Measures: Age, general health status, pubertal stage, bone age, height, weight, biochemical and hormonal analyses, and adverse side effects were determined at biannual check-ups.
Results: The mean height sd score gain for chronological age in children treated for 24 months (group I) was 2.10, whereas in those treated only during the last 12 months (group II) was 1.43. In both groups, children under 4 yr of age had the greatest gain in growth velocity. No significant acceleration of bone age or side effects related to treatment was seen.
Conclusion: Very young SGA children without spontaneous catch-up growth could benefit from GH treatment because growth was accelerated and no negative side effects were observed.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>17536000</pmid><doi>10.1210/jc.2007-0078</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0021-972X |
| ispartof | The journal of clinical endocrinology and metabolism, 2007-08, Vol.92 (8), p.3095-3101 |
| issn | 0021-972X 1945-7197 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68135803 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Age Determination by Skeleton Anthropometry Biological and medical sciences Body Height - drug effects Body Mass Index Child, Preschool Endocrinopathies Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Growth - drug effects Growth Hormone - administration & dosage Growth Hormone - adverse effects Growth Hormone - therapeutic use Humans Infant, Newborn Infant, Small for Gestational Age - growth & development Insulin-Like Growth Factor Binding Protein 3 - metabolism Insulin-Like Growth Factor I - metabolism Male Medical sciences Parents Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology |
| title | Improvement in Growth after Two Years of Growth Hormone Therapy in Very Young Children Born Small for Gestational Age and without Spontaneous Catch-Up Growth: Results of a Multicenter, Controlled, Randomized, Open Clinical Trial |
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