Discovery of 5-(4-hydroxy-6-methyl-2-oxo-2 H-pyran-3-yl)-7-phenyl-( E)-2,3,6,7-tetrahydro-1,4-thiazepines as a new series of apoptosis inducers using a cell- and caspase-based HTS assay

The discovery and SAR studies of 5-(4-hydroxy-6-methyl-2-oxo-2 H-pyran-3-yl)-7-phenyl-( E)-2,3,6,7-tetrahydro-1,4-thiazepines as a novel series of apoptosis inducers is reported. We report the discovery of 5-(4-hydroxy-6-methyl-2-oxo-2 H-pyran-3-yl)-7-(4-methylphenyl)-( E)-2,3,6,7-tetrahydro-1,4-thi...

Ausführliche Beschreibung