Confirmation of diminazene diaceturate in bovine plasma using electrospray liquid chromatography–mass spectrometry
Diminazene diaceturate is used as a trypanocide for cattle in tropical regions. This paper describes a LC–MS n method to confirm the presence of diminazene in bovine plasma. Bound diminazene in plasma samples was freed with dilute phosphoric acid, then concentrated on a bonded C 18 SPE cartridge. Th...
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| Veröffentlicht in: | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2006-11, Vol.844 (1), p.127-133 |
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| container_title | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences |
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| creator | Turnipseed, Sherri B. Clark, Susan B. Andersen, Wendy C. Karbiwnyk, Christine M. Miller, Keith E. Hurlbut, Jeffrey A. |
| description | Diminazene diaceturate is used as a trypanocide for cattle in tropical regions. This paper describes a LC–MS
n
method to confirm the presence of diminazene in bovine plasma. Bound diminazene in plasma samples was freed with dilute phosphoric acid, then concentrated on a bonded C
18 SPE cartridge. The LC–MS
n
method utilized electrospray ionization coupled with an ion trap mass spectrometer. Ions observed in MS
2 and MS
3 product ion spectra, as well as those from the MS
1 spectrum, were monitored. The method was validated with plasma samples fortified with diminazene diaceturate (4–100
ng/mL). Diminazene was confirmed in samples fortified with diminazene diaceturate at levels of 6.4
ng/mL or higher. |
| doi_str_mv | 10.1016/j.jchromb.2006.07.016 |
| format | Article |
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n
method to confirm the presence of diminazene in bovine plasma. Bound diminazene in plasma samples was freed with dilute phosphoric acid, then concentrated on a bonded C
18 SPE cartridge. The LC–MS
n
method utilized electrospray ionization coupled with an ion trap mass spectrometer. Ions observed in MS
2 and MS
3 product ion spectra, as well as those from the MS
1 spectrum, were monitored. The method was validated with plasma samples fortified with diminazene diaceturate (4–100
ng/mL). Diminazene was confirmed in samples fortified with diminazene diaceturate at levels of 6.4
ng/mL or higher.</description><identifier>ISSN: 1570-0232</identifier><identifier>EISSN: 1873-376X</identifier><identifier>DOI: 10.1016/j.jchromb.2006.07.016</identifier><identifier>PMID: 16891161</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analysis ; Analytical, structural and metabolic biochemistry ; Animals ; Biological and medical sciences ; Bovine plasma ; Cattle ; Chromatography, Liquid - methods ; Diminazene - analogs & derivatives ; Diminazene - blood ; Diminazene diaceturate ; Fundamental and applied biological sciences. Psychology ; General pharmacology ; Mass spectrometry ; Medical sciences ; Pharmacology. Drug treatments ; Reference Standards ; Spectrometry, Mass, Electrospray Ionization - methods ; Trypanocidal Agents - blood</subject><ispartof>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2006-11, Vol.844 (1), p.127-133</ispartof><rights>2006 Elsevier B.V.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-c2b25228a62bc131aab69a454f365c3a46251ec9c1bab247b6e8371b5fcfb3f53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jchromb.2006.07.016$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18281659$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16891161$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Turnipseed, Sherri B.</creatorcontrib><creatorcontrib>Clark, Susan B.</creatorcontrib><creatorcontrib>Andersen, Wendy C.</creatorcontrib><creatorcontrib>Karbiwnyk, Christine M.</creatorcontrib><creatorcontrib>Miller, Keith E.</creatorcontrib><creatorcontrib>Hurlbut, Jeffrey A.</creatorcontrib><title>Confirmation of diminazene diaceturate in bovine plasma using electrospray liquid chromatography–mass spectrometry</title><title>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences</title><addtitle>J Chromatogr B Analyt Technol Biomed Life Sci</addtitle><description>Diminazene diaceturate is used as a trypanocide for cattle in tropical regions. This paper describes a LC–MS
n
method to confirm the presence of diminazene in bovine plasma. Bound diminazene in plasma samples was freed with dilute phosphoric acid, then concentrated on a bonded C
18 SPE cartridge. The LC–MS
n
method utilized electrospray ionization coupled with an ion trap mass spectrometer. Ions observed in MS
2 and MS
3 product ion spectra, as well as those from the MS
1 spectrum, were monitored. The method was validated with plasma samples fortified with diminazene diaceturate (4–100
ng/mL). Diminazene was confirmed in samples fortified with diminazene diaceturate at levels of 6.4
ng/mL or higher.</description><subject>Analysis</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bovine plasma</subject><subject>Cattle</subject><subject>Chromatography, Liquid - methods</subject><subject>Diminazene - analogs & derivatives</subject><subject>Diminazene - blood</subject><subject>Diminazene diaceturate</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>Mass spectrometry</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Reference Standards</subject><subject>Spectrometry, Mass, Electrospray Ionization - methods</subject><subject>Trypanocidal Agents - blood</subject><issn>1570-0232</issn><issn>1873-376X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtu1TAQhiMEoqXwCKBsYJfgS-zkrBA6KhepEhuQ2FljZ9L6KLZT26l0WPEOvCFPgtsTqUtWHv36ZjzzVdVrSlpKqHx_aA_mJganW0aIbEnflvRJdU6Hnje8lz-fllr0pCGMs7PqRUoHQmhPev68OqNy2FEq6XmV98FPNjrINvg6TPVonfXwCz2WEgzmNULG2vpahztb0mWG5KBek_XXNc5ocgxpiXCsZ3u72rF-WAtyuI6w3Bz__v7jIKU6LQ-kwxyPL6tnE8wJX23vRfXj0-X3_Zfm6tvnr_uPV43pGMuNYZoJxgaQTBvKKYCWO-hEN3EpDIdOMkHR7AzVoFnXa4kD76kWk5k0nwS_qN6d5i4x3K6YsnI2GZxn8BjWpORAeTdQVkBxAk25JUWc1BKtg3hUlKh73eqgNt3qXrcivSpp6XuzfbBqh-Nj1-a3AG83AJKBeYrgjU2P3MAGKsWucB9OHBYddxajSsaiNzjaWLypMdj_rPIPUHaleg</recordid><startdate>20061121</startdate><enddate>20061121</enddate><creator>Turnipseed, Sherri B.</creator><creator>Clark, Susan B.</creator><creator>Andersen, Wendy C.</creator><creator>Karbiwnyk, Christine M.</creator><creator>Miller, Keith E.</creator><creator>Hurlbut, Jeffrey A.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20061121</creationdate><title>Confirmation of diminazene diaceturate in bovine plasma using electrospray liquid chromatography–mass spectrometry</title><author>Turnipseed, Sherri B. ; Clark, Susan B. ; Andersen, Wendy C. ; Karbiwnyk, Christine M. ; Miller, Keith E. ; Hurlbut, Jeffrey A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-c2b25228a62bc131aab69a454f365c3a46251ec9c1bab247b6e8371b5fcfb3f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Analysis</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bovine plasma</topic><topic>Cattle</topic><topic>Chromatography, Liquid - methods</topic><topic>Diminazene - analogs & derivatives</topic><topic>Diminazene - blood</topic><topic>Diminazene diaceturate</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General pharmacology</topic><topic>Mass spectrometry</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Reference Standards</topic><topic>Spectrometry, Mass, Electrospray Ionization - methods</topic><topic>Trypanocidal Agents - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Turnipseed, Sherri B.</creatorcontrib><creatorcontrib>Clark, Susan B.</creatorcontrib><creatorcontrib>Andersen, Wendy C.</creatorcontrib><creatorcontrib>Karbiwnyk, Christine M.</creatorcontrib><creatorcontrib>Miller, Keith E.</creatorcontrib><creatorcontrib>Hurlbut, Jeffrey A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Turnipseed, Sherri B.</au><au>Clark, Susan B.</au><au>Andersen, Wendy C.</au><au>Karbiwnyk, Christine M.</au><au>Miller, Keith E.</au><au>Hurlbut, Jeffrey A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Confirmation of diminazene diaceturate in bovine plasma using electrospray liquid chromatography–mass spectrometry</atitle><jtitle>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences</jtitle><addtitle>J Chromatogr B Analyt Technol Biomed Life Sci</addtitle><date>2006-11-21</date><risdate>2006</risdate><volume>844</volume><issue>1</issue><spage>127</spage><epage>133</epage><pages>127-133</pages><issn>1570-0232</issn><eissn>1873-376X</eissn><abstract>Diminazene diaceturate is used as a trypanocide for cattle in tropical regions. This paper describes a LC–MS
n
method to confirm the presence of diminazene in bovine plasma. Bound diminazene in plasma samples was freed with dilute phosphoric acid, then concentrated on a bonded C
18 SPE cartridge. The LC–MS
n
method utilized electrospray ionization coupled with an ion trap mass spectrometer. Ions observed in MS
2 and MS
3 product ion spectra, as well as those from the MS
1 spectrum, were monitored. The method was validated with plasma samples fortified with diminazene diaceturate (4–100
ng/mL). Diminazene was confirmed in samples fortified with diminazene diaceturate at levels of 6.4
ng/mL or higher.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>16891161</pmid><doi>10.1016/j.jchromb.2006.07.016</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2006-11, Vol.844 (1), p.127-133 |
| issn | 1570-0232 1873-376X |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Analysis Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Bovine plasma Cattle Chromatography, Liquid - methods Diminazene - analogs & derivatives Diminazene - blood Diminazene diaceturate Fundamental and applied biological sciences. Psychology General pharmacology Mass spectrometry Medical sciences Pharmacology. Drug treatments Reference Standards Spectrometry, Mass, Electrospray Ionization - methods Trypanocidal Agents - blood |
| title | Confirmation of diminazene diaceturate in bovine plasma using electrospray liquid chromatography–mass spectrometry |
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