Nonalcoholic fatty liver disease decrease in obese adolescents after multidisciplinary therapy
BACKGROUNDDespite the increasing prevalence of nonalcoholic fatty liver disease, its pathogenesis and clinical significance remain poorly defined and there is no ideal treatment. OBJECTIVEThe aim of this study was to assess the short-term (12-week) multidisciplinary therapy on visceral adiposity and...
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| Veröffentlicht in: | European journal of gastroenterology & hepatology 2006-12, Vol.18 (12), p.1241-1245 |
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| container_title | European journal of gastroenterology & hepatology |
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| creator | Tock, Lian Prado, Wagner L Caranti, Danielle A Cristofalo, Dejaldo M.J Lederman, Henrique Fisberg, Mauro Siqueira, Kãli O Stella, Sérgio G Antunes, Hanna K Cintra, Isa P Tufik, Sérgio Túlio de Mello, Marco Dâmaso, Ana R |
| description | BACKGROUNDDespite the increasing prevalence of nonalcoholic fatty liver disease, its pathogenesis and clinical significance remain poorly defined and there is no ideal treatment.
OBJECTIVEThe aim of this study was to assess the short-term (12-week) multidisciplinary therapy on visceral adiposity and nonalcoholic fatty liver disease control.
METHODSWe evaluated and compared the distribution of visceral adiposity and nonalcoholic fatty liver disease, by ultrasonography, in 73 post-puberty obese participants (17.01±1.6 years old; body mass index 36.54±2.86 kg/m), submitted to a multidisciplinary treatment without medications, at the beginning and after 12 weeks of intervention. Descriptive and one-way analysis of variance, and paired t-test were performed.
RESULTSThe results indicated that after intervention the adolescents had a significant reduction in visceral adiposity (4.05±1.55 to 3.37±1.44) and nonalcoholic fatty liver disease prevalence (from 52 to 29% on the right side and from 48 to 29% on the left side). It is a positive result because nonalcoholic fatty liver disease can progress to cirrhosis, even in children and adolescents.
CONCLUSIONSThe short-term treatment suggests a profound impact on the control of obesity-related co-morbidities in young people. |
| doi_str_mv | 10.1097/01.meg.0000243872.86949.95 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68134467</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68134467</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3921-b7f502016cbe64f0b2352c74c2702ee85d1014da9473bd5fb896397958d460ee3</originalsourceid><addsrcrecordid>eNpFkE1v1DAQhi1ERZfCX0AREtySjr9jbqgqH1IFl1bihOU4E9bgJIudUO2_x9tdaX2w5_DMzOuHkLcUGgpGXwNtRvzVQDlM8FazplVGmMbIZ2RDhea1VK1-TjZgpKiVoT8uycucfwNQzal-QS6pBmO4phvy89s8uejn7RyDrwa3LPsqhn-Yqj5kdBmrHn16KsJUzR2WwvVzxOxxWnLlhqWw4xqXUBp82MUwubSvli0mt9u_IheDixlfn94r8vDp9v7mS333_fPXm493teeG0brTgwQGVPkOlRigY1wyr4VnGhhiK3sKVPTOlM91vRy61ihutJFtLxQg8ivy_jh3l-a_K-bFjiUNxugmnNdsVUu5EEoX8MMR9GnOOeFgdymMJbGlYA92LVBb7NqzXftk1xpZmt-ctqzdiP259aSzAO9OgMvexSG5yYd85loOUqvDIHHkHudY_OU_cX3EZLfo4rI9rBZMc10zAEXLBfUhDeX_AZH-lIk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68134467</pqid></control><display><type>article</type><title>Nonalcoholic fatty liver disease decrease in obese adolescents after multidisciplinary therapy</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Tock, Lian ; Prado, Wagner L ; Caranti, Danielle A ; Cristofalo, Dejaldo M.J ; Lederman, Henrique ; Fisberg, Mauro ; Siqueira, Kãli O ; Stella, Sérgio G ; Antunes, Hanna K ; Cintra, Isa P ; Tufik, Sérgio ; Túlio de Mello, Marco ; Dâmaso, Ana R</creator><creatorcontrib>Tock, Lian ; Prado, Wagner L ; Caranti, Danielle A ; Cristofalo, Dejaldo M.J ; Lederman, Henrique ; Fisberg, Mauro ; Siqueira, Kãli O ; Stella, Sérgio G ; Antunes, Hanna K ; Cintra, Isa P ; Tufik, Sérgio ; Túlio de Mello, Marco ; Dâmaso, Ana R</creatorcontrib><description>BACKGROUNDDespite the increasing prevalence of nonalcoholic fatty liver disease, its pathogenesis and clinical significance remain poorly defined and there is no ideal treatment.
OBJECTIVEThe aim of this study was to assess the short-term (12-week) multidisciplinary therapy on visceral adiposity and nonalcoholic fatty liver disease control.
METHODSWe evaluated and compared the distribution of visceral adiposity and nonalcoholic fatty liver disease, by ultrasonography, in 73 post-puberty obese participants (17.01±1.6 years old; body mass index 36.54±2.86 kg/m), submitted to a multidisciplinary treatment without medications, at the beginning and after 12 weeks of intervention. Descriptive and one-way analysis of variance, and paired t-test were performed.
RESULTSThe results indicated that after intervention the adolescents had a significant reduction in visceral adiposity (4.05±1.55 to 3.37±1.44) and nonalcoholic fatty liver disease prevalence (from 52 to 29% on the right side and from 48 to 29% on the left side). It is a positive result because nonalcoholic fatty liver disease can progress to cirrhosis, even in children and adolescents.
CONCLUSIONSThe short-term treatment suggests a profound impact on the control of obesity-related co-morbidities in young people.</description><identifier>ISSN: 0954-691X</identifier><identifier>EISSN: 1473-5687</identifier><identifier>DOI: 10.1097/01.meg.0000243872.86949.95</identifier><identifier>PMID: 17099371</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Adiposity ; Adolescent ; Adult ; Anthropometry ; Biological and medical sciences ; Blood Glucose - metabolism ; Body Mass Index ; Combined Modality Therapy ; Diet, Reducing ; Eating ; Exercise ; Fatty Liver - diagnostic imaging ; Fatty Liver - etiology ; Female ; Follow-Up Studies ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Insulin - blood ; Life Style ; Lipids - blood ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Metabolic diseases ; Obesity ; Obesity - complications ; Obesity - diagnostic imaging ; Obesity - physiopathology ; Obesity - therapy ; Other diseases. Semiology ; Severity of Illness Index ; Treatment Outcome ; Ultrasonography</subject><ispartof>European journal of gastroenterology & hepatology, 2006-12, Vol.18 (12), p.1241-1245</ispartof><rights>2006 Lippincott Williams & Wilkins, Inc.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3921-b7f502016cbe64f0b2352c74c2702ee85d1014da9473bd5fb896397958d460ee3</citedby><cites>FETCH-LOGICAL-c3921-b7f502016cbe64f0b2352c74c2702ee85d1014da9473bd5fb896397958d460ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18305765$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17099371$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tock, Lian</creatorcontrib><creatorcontrib>Prado, Wagner L</creatorcontrib><creatorcontrib>Caranti, Danielle A</creatorcontrib><creatorcontrib>Cristofalo, Dejaldo M.J</creatorcontrib><creatorcontrib>Lederman, Henrique</creatorcontrib><creatorcontrib>Fisberg, Mauro</creatorcontrib><creatorcontrib>Siqueira, Kãli O</creatorcontrib><creatorcontrib>Stella, Sérgio G</creatorcontrib><creatorcontrib>Antunes, Hanna K</creatorcontrib><creatorcontrib>Cintra, Isa P</creatorcontrib><creatorcontrib>Tufik, Sérgio</creatorcontrib><creatorcontrib>Túlio de Mello, Marco</creatorcontrib><creatorcontrib>Dâmaso, Ana R</creatorcontrib><title>Nonalcoholic fatty liver disease decrease in obese adolescents after multidisciplinary therapy</title><title>European journal of gastroenterology & hepatology</title><addtitle>Eur J Gastroenterol Hepatol</addtitle><description>BACKGROUNDDespite the increasing prevalence of nonalcoholic fatty liver disease, its pathogenesis and clinical significance remain poorly defined and there is no ideal treatment.
OBJECTIVEThe aim of this study was to assess the short-term (12-week) multidisciplinary therapy on visceral adiposity and nonalcoholic fatty liver disease control.
METHODSWe evaluated and compared the distribution of visceral adiposity and nonalcoholic fatty liver disease, by ultrasonography, in 73 post-puberty obese participants (17.01±1.6 years old; body mass index 36.54±2.86 kg/m), submitted to a multidisciplinary treatment without medications, at the beginning and after 12 weeks of intervention. Descriptive and one-way analysis of variance, and paired t-test were performed.
RESULTSThe results indicated that after intervention the adolescents had a significant reduction in visceral adiposity (4.05±1.55 to 3.37±1.44) and nonalcoholic fatty liver disease prevalence (from 52 to 29% on the right side and from 48 to 29% on the left side). It is a positive result because nonalcoholic fatty liver disease can progress to cirrhosis, even in children and adolescents.
CONCLUSIONSThe short-term treatment suggests a profound impact on the control of obesity-related co-morbidities in young people.</description><subject>Adiposity</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Anthropometry</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Body Mass Index</subject><subject>Combined Modality Therapy</subject><subject>Diet, Reducing</subject><subject>Eating</subject><subject>Exercise</subject><subject>Fatty Liver - diagnostic imaging</subject><subject>Fatty Liver - etiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Life Style</subject><subject>Lipids - blood</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Obesity - diagnostic imaging</subject><subject>Obesity - physiopathology</subject><subject>Obesity - therapy</subject><subject>Other diseases. Semiology</subject><subject>Severity of Illness Index</subject><subject>Treatment Outcome</subject><subject>Ultrasonography</subject><issn>0954-691X</issn><issn>1473-5687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1v1DAQhi1ERZfCX0AREtySjr9jbqgqH1IFl1bihOU4E9bgJIudUO2_x9tdaX2w5_DMzOuHkLcUGgpGXwNtRvzVQDlM8FazplVGmMbIZ2RDhea1VK1-TjZgpKiVoT8uycucfwNQzal-QS6pBmO4phvy89s8uejn7RyDrwa3LPsqhn-Yqj5kdBmrHn16KsJUzR2WwvVzxOxxWnLlhqWw4xqXUBp82MUwubSvli0mt9u_IheDixlfn94r8vDp9v7mS333_fPXm493teeG0brTgwQGVPkOlRigY1wyr4VnGhhiK3sKVPTOlM91vRy61ihutJFtLxQg8ivy_jh3l-a_K-bFjiUNxugmnNdsVUu5EEoX8MMR9GnOOeFgdymMJbGlYA92LVBb7NqzXftk1xpZmt-ctqzdiP259aSzAO9OgMvexSG5yYd85loOUqvDIHHkHudY_OU_cX3EZLfo4rI9rBZMc10zAEXLBfUhDeX_AZH-lIk</recordid><startdate>200612</startdate><enddate>200612</enddate><creator>Tock, Lian</creator><creator>Prado, Wagner L</creator><creator>Caranti, Danielle A</creator><creator>Cristofalo, Dejaldo M.J</creator><creator>Lederman, Henrique</creator><creator>Fisberg, Mauro</creator><creator>Siqueira, Kãli O</creator><creator>Stella, Sérgio G</creator><creator>Antunes, Hanna K</creator><creator>Cintra, Isa P</creator><creator>Tufik, Sérgio</creator><creator>Túlio de Mello, Marco</creator><creator>Dâmaso, Ana R</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200612</creationdate><title>Nonalcoholic fatty liver disease decrease in obese adolescents after multidisciplinary therapy</title><author>Tock, Lian ; Prado, Wagner L ; Caranti, Danielle A ; Cristofalo, Dejaldo M.J ; Lederman, Henrique ; Fisberg, Mauro ; Siqueira, Kãli O ; Stella, Sérgio G ; Antunes, Hanna K ; Cintra, Isa P ; Tufik, Sérgio ; Túlio de Mello, Marco ; Dâmaso, Ana R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3921-b7f502016cbe64f0b2352c74c2702ee85d1014da9473bd5fb896397958d460ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adiposity</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Anthropometry</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Body Mass Index</topic><topic>Combined Modality Therapy</topic><topic>Diet, Reducing</topic><topic>Eating</topic><topic>Exercise</topic><topic>Fatty Liver - diagnostic imaging</topic><topic>Fatty Liver - etiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Life Style</topic><topic>Lipids - blood</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Obesity</topic><topic>Obesity - complications</topic><topic>Obesity - diagnostic imaging</topic><topic>Obesity - physiopathology</topic><topic>Obesity - therapy</topic><topic>Other diseases. Semiology</topic><topic>Severity of Illness Index</topic><topic>Treatment Outcome</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tock, Lian</creatorcontrib><creatorcontrib>Prado, Wagner L</creatorcontrib><creatorcontrib>Caranti, Danielle A</creatorcontrib><creatorcontrib>Cristofalo, Dejaldo M.J</creatorcontrib><creatorcontrib>Lederman, Henrique</creatorcontrib><creatorcontrib>Fisberg, Mauro</creatorcontrib><creatorcontrib>Siqueira, Kãli O</creatorcontrib><creatorcontrib>Stella, Sérgio G</creatorcontrib><creatorcontrib>Antunes, Hanna K</creatorcontrib><creatorcontrib>Cintra, Isa P</creatorcontrib><creatorcontrib>Tufik, Sérgio</creatorcontrib><creatorcontrib>Túlio de Mello, Marco</creatorcontrib><creatorcontrib>Dâmaso, Ana R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of gastroenterology & hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tock, Lian</au><au>Prado, Wagner L</au><au>Caranti, Danielle A</au><au>Cristofalo, Dejaldo M.J</au><au>Lederman, Henrique</au><au>Fisberg, Mauro</au><au>Siqueira, Kãli O</au><au>Stella, Sérgio G</au><au>Antunes, Hanna K</au><au>Cintra, Isa P</au><au>Tufik, Sérgio</au><au>Túlio de Mello, Marco</au><au>Dâmaso, Ana R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nonalcoholic fatty liver disease decrease in obese adolescents after multidisciplinary therapy</atitle><jtitle>European journal of gastroenterology & hepatology</jtitle><addtitle>Eur J Gastroenterol Hepatol</addtitle><date>2006-12</date><risdate>2006</risdate><volume>18</volume><issue>12</issue><spage>1241</spage><epage>1245</epage><pages>1241-1245</pages><issn>0954-691X</issn><eissn>1473-5687</eissn><abstract>BACKGROUNDDespite the increasing prevalence of nonalcoholic fatty liver disease, its pathogenesis and clinical significance remain poorly defined and there is no ideal treatment.
OBJECTIVEThe aim of this study was to assess the short-term (12-week) multidisciplinary therapy on visceral adiposity and nonalcoholic fatty liver disease control.
METHODSWe evaluated and compared the distribution of visceral adiposity and nonalcoholic fatty liver disease, by ultrasonography, in 73 post-puberty obese participants (17.01±1.6 years old; body mass index 36.54±2.86 kg/m), submitted to a multidisciplinary treatment without medications, at the beginning and after 12 weeks of intervention. Descriptive and one-way analysis of variance, and paired t-test were performed.
RESULTSThe results indicated that after intervention the adolescents had a significant reduction in visceral adiposity (4.05±1.55 to 3.37±1.44) and nonalcoholic fatty liver disease prevalence (from 52 to 29% on the right side and from 48 to 29% on the left side). It is a positive result because nonalcoholic fatty liver disease can progress to cirrhosis, even in children and adolescents.
CONCLUSIONSThe short-term treatment suggests a profound impact on the control of obesity-related co-morbidities in young people.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>17099371</pmid><doi>10.1097/01.meg.0000243872.86949.95</doi><tpages>5</tpages></addata></record> |
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| subjects | Adiposity Adolescent Adult Anthropometry Biological and medical sciences Blood Glucose - metabolism Body Mass Index Combined Modality Therapy Diet, Reducing Eating Exercise Fatty Liver - diagnostic imaging Fatty Liver - etiology Female Follow-Up Studies Gastroenterology. Liver. Pancreas. Abdomen Humans Insulin - blood Life Style Lipids - blood Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Metabolic diseases Obesity Obesity - complications Obesity - diagnostic imaging Obesity - physiopathology Obesity - therapy Other diseases. Semiology Severity of Illness Index Treatment Outcome Ultrasonography |
| title | Nonalcoholic fatty liver disease decrease in obese adolescents after multidisciplinary therapy |
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