Diphtheria, pertussis, and tetanus serosurvey in Saudi children
To evaluate immune protection against vaccine-preventable diseases targeted by the Expanded Program of Immunization in Saudi Arabia. The study was carried out from September 2001 to February 2002. Using multistage sampling techniques, samples were collected from 5 regions of Saudi Arabia and sent fo...
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| Veröffentlicht in: | Saudi medical journal 2007-08, Vol.28 (8), p.1230-1233 |
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| container_title | Saudi medical journal |
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| creator | AL-MAZROU, Yagob Y KHALIL, Mohamed K ELGIZOULI, Sirag A AL-JEFFRI, Mahomed H BAKHSH, Mohamed M MISHKAIS, Ameen A |
| description | To evaluate immune protection against vaccine-preventable diseases targeted by the Expanded Program of Immunization in Saudi Arabia.
The study was carried out from September 2001 to February 2002. Using multistage sampling techniques, samples were collected from 5 regions of Saudi Arabia and sent for laboratory assay from the following age groups; 50 samples at 12 months, 50 at 6 years, and 100 at 17 years. Sera were assayed for diphtheria, tetanus, and pertussis. Sero neutralization was used for anti-diphtheria antibody assay, while enzyme linked immunoassay was used for anti-tetanus, anti-filament hemoagglutination (anti-FHA), and anti-pertussis titer (anti-PT) antibody assay.
This survey showed that 100% of children had protection levels (>/=0.01 IU/ml) against diphtheria at one year, 100% at 6 years, and 93.7% at 17 years. For tetanus, 95.9% had protection levels (>/=0.1 IU/ml) at one year, 100% at 6 years, and 98.9% at 17 years. The geometric mean titer (GMT) of anti-FHA is 22 at one year, 29 at 6 years, and 24 IU/ml at 17 years, while the GMT of anti-PT is 36 at one year, 18 at 6 years, and 11 IU/ml at 17 years.
Children at one, 6, and 17 years are well protected against diphtheria, pertussis, and tetanus. |
| format | Article |
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The study was carried out from September 2001 to February 2002. Using multistage sampling techniques, samples were collected from 5 regions of Saudi Arabia and sent for laboratory assay from the following age groups; 50 samples at 12 months, 50 at 6 years, and 100 at 17 years. Sera were assayed for diphtheria, tetanus, and pertussis. Sero neutralization was used for anti-diphtheria antibody assay, while enzyme linked immunoassay was used for anti-tetanus, anti-filament hemoagglutination (anti-FHA), and anti-pertussis titer (anti-PT) antibody assay.
This survey showed that 100% of children had protection levels (>/=0.01 IU/ml) against diphtheria at one year, 100% at 6 years, and 93.7% at 17 years. For tetanus, 95.9% had protection levels (>/=0.1 IU/ml) at one year, 100% at 6 years, and 98.9% at 17 years. The geometric mean titer (GMT) of anti-FHA is 22 at one year, 29 at 6 years, and 24 IU/ml at 17 years, while the GMT of anti-PT is 36 at one year, 18 at 6 years, and 11 IU/ml at 17 years.
Children at one, 6, and 17 years are well protected against diphtheria, pertussis, and tetanus.</description><identifier>ISSN: 0379-5284</identifier><identifier>PMID: 17676208</identifier><identifier>CODEN: SAMJDI</identifier><language>eng</language><publisher>Riyadh: Saudi Medical Journal</publisher><subject>Adolescent ; Age Factors ; Antibodies, Bacterial - blood ; Bacterial diseases ; Bacterial diseases of the nervous system. Bacterial myositis ; Biological and medical sciences ; Child ; Child, Preschool ; Diphtheria - immunology ; Ent and stomatologic bacterial diseases ; General aspects ; Human bacterial diseases ; Humans ; Immunity, Active - physiology ; Infant ; Infectious diseases ; Medical sciences ; Saudi Arabia ; Seroepidemiologic Studies ; Tetanus - immunology ; Whooping Cough - immunology</subject><ispartof>Saudi medical journal, 2007-08, Vol.28 (8), p.1230-1233</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19011280$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17676208$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>AL-MAZROU, Yagob Y</creatorcontrib><creatorcontrib>KHALIL, Mohamed K</creatorcontrib><creatorcontrib>ELGIZOULI, Sirag A</creatorcontrib><creatorcontrib>AL-JEFFRI, Mahomed H</creatorcontrib><creatorcontrib>BAKHSH, Mohamed M</creatorcontrib><creatorcontrib>MISHKAIS, Ameen A</creatorcontrib><title>Diphtheria, pertussis, and tetanus serosurvey in Saudi children</title><title>Saudi medical journal</title><addtitle>Saudi Med J</addtitle><description>To evaluate immune protection against vaccine-preventable diseases targeted by the Expanded Program of Immunization in Saudi Arabia.
The study was carried out from September 2001 to February 2002. Using multistage sampling techniques, samples were collected from 5 regions of Saudi Arabia and sent for laboratory assay from the following age groups; 50 samples at 12 months, 50 at 6 years, and 100 at 17 years. Sera were assayed for diphtheria, tetanus, and pertussis. Sero neutralization was used for anti-diphtheria antibody assay, while enzyme linked immunoassay was used for anti-tetanus, anti-filament hemoagglutination (anti-FHA), and anti-pertussis titer (anti-PT) antibody assay.
This survey showed that 100% of children had protection levels (>/=0.01 IU/ml) against diphtheria at one year, 100% at 6 years, and 93.7% at 17 years. For tetanus, 95.9% had protection levels (>/=0.1 IU/ml) at one year, 100% at 6 years, and 98.9% at 17 years. The geometric mean titer (GMT) of anti-FHA is 22 at one year, 29 at 6 years, and 24 IU/ml at 17 years, while the GMT of anti-PT is 36 at one year, 18 at 6 years, and 11 IU/ml at 17 years.
Children at one, 6, and 17 years are well protected against diphtheria, pertussis, and tetanus.</description><subject>Adolescent</subject><subject>Age Factors</subject><subject>Antibodies, Bacterial - blood</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the nervous system. Bacterial myositis</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Diphtheria - immunology</subject><subject>Ent and stomatologic bacterial diseases</subject><subject>General aspects</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Immunity, Active - physiology</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Saudi Arabia</subject><subject>Seroepidemiologic Studies</subject><subject>Tetanus - immunology</subject><subject>Whooping Cough - immunology</subject><issn>0379-5284</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFz01LxDAUheEsFGcc_QuSja6mkDRtmq5Exk8YcKGuy21yQyOdTs1thPn3DlhxdTYPB94TthSqqrMyN8WCnRN9CqG0FvqMLWSlK50Ls2S392Hspg5jgDUfMU6JKNCaw-D4hBMMiThh3FOK33jgYeBvkFzgtgu9izhcsFMPPeHlvCv28fjwvnnOtq9PL5u7bTbmqp4yDd56nVcGhK-dBy1c7UprUUPlldC21apuwSjRSvTSFsYqabXzpZFFjqBW7Ob3d4z7r4Q0NbtAFvseBtwnarSRqpCmOMKrGaZ2h64ZY9hBPDR_yUdwPQMgC72PMNhA_64WUuZGqB_Utl83</recordid><startdate>20070801</startdate><enddate>20070801</enddate><creator>AL-MAZROU, Yagob Y</creator><creator>KHALIL, Mohamed K</creator><creator>ELGIZOULI, Sirag A</creator><creator>AL-JEFFRI, Mahomed H</creator><creator>BAKHSH, Mohamed M</creator><creator>MISHKAIS, Ameen A</creator><general>Saudi Medical Journal</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20070801</creationdate><title>Diphtheria, pertussis, and tetanus serosurvey in Saudi children</title><author>AL-MAZROU, Yagob Y ; KHALIL, Mohamed K ; ELGIZOULI, Sirag A ; AL-JEFFRI, Mahomed H ; BAKHSH, Mohamed M ; MISHKAIS, Ameen A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p239t-6afcf6278a0f9dfa60d9d5cce6a7f306cb639ba830b1ef1c48c31c6df58142ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Age Factors</topic><topic>Antibodies, Bacterial - blood</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the nervous system. Bacterial myositis</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Diphtheria - immunology</topic><topic>Ent and stomatologic bacterial diseases</topic><topic>General aspects</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Immunity, Active - physiology</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Saudi Arabia</topic><topic>Seroepidemiologic Studies</topic><topic>Tetanus - immunology</topic><topic>Whooping Cough - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>AL-MAZROU, Yagob Y</creatorcontrib><creatorcontrib>KHALIL, Mohamed K</creatorcontrib><creatorcontrib>ELGIZOULI, Sirag A</creatorcontrib><creatorcontrib>AL-JEFFRI, Mahomed H</creatorcontrib><creatorcontrib>BAKHSH, Mohamed M</creatorcontrib><creatorcontrib>MISHKAIS, Ameen A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Saudi medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>AL-MAZROU, Yagob Y</au><au>KHALIL, Mohamed K</au><au>ELGIZOULI, Sirag A</au><au>AL-JEFFRI, Mahomed H</au><au>BAKHSH, Mohamed M</au><au>MISHKAIS, Ameen A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diphtheria, pertussis, and tetanus serosurvey in Saudi children</atitle><jtitle>Saudi medical journal</jtitle><addtitle>Saudi Med J</addtitle><date>2007-08-01</date><risdate>2007</risdate><volume>28</volume><issue>8</issue><spage>1230</spage><epage>1233</epage><pages>1230-1233</pages><issn>0379-5284</issn><coden>SAMJDI</coden><abstract>To evaluate immune protection against vaccine-preventable diseases targeted by the Expanded Program of Immunization in Saudi Arabia.
The study was carried out from September 2001 to February 2002. Using multistage sampling techniques, samples were collected from 5 regions of Saudi Arabia and sent for laboratory assay from the following age groups; 50 samples at 12 months, 50 at 6 years, and 100 at 17 years. Sera were assayed for diphtheria, tetanus, and pertussis. Sero neutralization was used for anti-diphtheria antibody assay, while enzyme linked immunoassay was used for anti-tetanus, anti-filament hemoagglutination (anti-FHA), and anti-pertussis titer (anti-PT) antibody assay.
This survey showed that 100% of children had protection levels (>/=0.01 IU/ml) against diphtheria at one year, 100% at 6 years, and 93.7% at 17 years. For tetanus, 95.9% had protection levels (>/=0.1 IU/ml) at one year, 100% at 6 years, and 98.9% at 17 years. The geometric mean titer (GMT) of anti-FHA is 22 at one year, 29 at 6 years, and 24 IU/ml at 17 years, while the GMT of anti-PT is 36 at one year, 18 at 6 years, and 11 IU/ml at 17 years.
Children at one, 6, and 17 years are well protected against diphtheria, pertussis, and tetanus.</abstract><cop>Riyadh</cop><pub>Saudi Medical Journal</pub><pmid>17676208</pmid><tpages>4</tpages></addata></record> |
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| subjects | Adolescent Age Factors Antibodies, Bacterial - blood Bacterial diseases Bacterial diseases of the nervous system. Bacterial myositis Biological and medical sciences Child Child, Preschool Diphtheria - immunology Ent and stomatologic bacterial diseases General aspects Human bacterial diseases Humans Immunity, Active - physiology Infant Infectious diseases Medical sciences Saudi Arabia Seroepidemiologic Studies Tetanus - immunology Whooping Cough - immunology |
| title | Diphtheria, pertussis, and tetanus serosurvey in Saudi children |
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