Sulfenamides as prodrugs of NH-acidic compounds: A new prodrug option for the amide bond

The objective of this report is to introduce the novel concept of utilizing sulfenamides as prodrugs for compounds containing an NH-acidic functionality, particularly weakly acidic amide-type functionalities. The objective of this report is to introduce the novel concept of utilizing sulfenamides as...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2007-09, Vol.17 (17), p.4910-4913
Hauptverfasser:	Guarino, Victor R., Karunaratne, Veranja, Stella, Valentino J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amide Amides - chemistry Amides - pharmacology Amines - chemistry Bioavailability Biological and medical sciences Chemical Phenomena Chemistry Chemistry, Pharmaceutical - methods Dissolution rate Drug Design Hydrogen-Ion Concentration Hydrolysis Kinetics Medical sciences Miscellaneous Models, Chemical NH-acid Permeability Pharmacology. Drug treatments Prodrug Prodrugs - chemistry Prodrugs - pharmacology Solubility Stability Sulfenamide Sulfur - chemistry Temperature
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