Fibroblasts Derive from Hepatocytes in Liver Fibrosis via Epithelial to Mesenchymal Transition

Activated fibroblasts are key contributors to the fibrotic extracellular matrix accumulation during liver fibrosis. The origin of such fibroblasts is still debated, although several studies point to stellate cells as the principal source. The role of adult hepatocytes as contributors to the accumula...

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Veröffentlicht in:	The Journal of biological chemistry 2007-08, Vol.282 (32), p.23337-23347
Hauptverfasser:	Zeisberg, Michael, Yang, Changqing, Martino, Margot, Duncan, Michael B., Rieder, Florian, Tanjore, Harikrishna, Kalluri, Raghu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Morphogenetic Protein 7 Bone Morphogenetic Proteins - metabolism Cell Differentiation Cell Lineage Epithelium - pathology Fibroblasts - cytology Fibroblasts - metabolism Fibrosis - pathology Hepatocytes - cytology Hepatocytes - metabolism Humans Liver - pathology Mesoderm - pathology Mice Mice, Inbred C57BL Mice, Transgenic Models, Biological Transforming Growth Factor beta - metabolism
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