The negative regulators Foxj1 and Foxo3a are up‐regulated by a peptide that inhibits systemic lupus erythematosus‐associated T cell responses

A peptide (hCDR1) based on the complementarity determining region‐1 of an anti‐DNA antibody ameliorates systemic lupus erythematosus (SLE) in induced and spontaneous lupus models. Our objectives were to determine the effects of hCDR1 on TCR signaling and on its negative regulators, Foxj1 and Foxo3a....

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Veröffentlicht in:	European Journal of Immunology 2006-11, Vol.36 (11), p.2971-2980
Hauptverfasser:	Sela, Uri, Dayan, Molly, Hershkoviz, Rami, Cahalon, Liora, Lider, Ofer, Mozes, Edna
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacology Cytokines Female Forkhead Box Protein O3 Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Immunomodulatory peptide Interferon-gamma - antagonists & inhibitors Interferon-gamma - metabolism Lupus Lupus Erythematosus, Systemic - immunology Mice Mice, Inbred BALB C NF-kappa B - metabolism Peptide Fragments - pharmacology Peptides - pharmacology Phosphorylation - drug effects Receptors, Antigen, T-Cell - antagonists & inhibitors Receptors, Antigen, T-Cell - metabolism RNA, Messenger - metabolism T cells T-Box Domain Proteins - metabolism T-Lymphocytes - drug effects T-Lymphocytes - immunology Transcription factors Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism Transforming Growth Factor beta - pharmacology Up-Regulation ZAP-70 Protein-Tyrosine Kinase - metabolism
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