Intratumoral Microvessel Density in Advanced Epithelial Ovarian Cancer and its Use as a Prognostic Variable
Background: The aim of this retrospective study was to assess whether the intratumoral microvessel density (IMD) in primary tumour specimens had any impact on the clinical outcome of patients with advanced epithelial ovarian cancer treated in two Italian departments of gynaecological oncology. Mater...
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| Veröffentlicht in: | Anticancer research 2006-09, Vol.26 (5B), p.3925-3932 |
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| creator | GADDUCCI, Angiolo FERRERO, Annamaria GENAZZANI, Andrea Riccardo COSIO, Stefania ZOLA, Paolo VIACAVA, Paolo DOMPE, Daniela FANELLI, Giovanni RAVARINO, Nicoletta MOTTA, Manuela CRISTOFANI, Renza |
| description | Background: The aim of this retrospective study was to assess whether the intratumoral microvessel density (IMD) in primary
tumour specimens had any impact on the clinical outcome of patients with advanced epithelial ovarian cancer treated in two
Italian departments of gynaecological oncology. Materials and Methods: The study was conducted on 101 patients who underwent
initial surgery followed by platinum-based chemotherapy (37) or paclitaxel/platinum-based chemotherapy (64) for International
Federation of Gynecology and Obstetrics (FIGO) stage III-IV epithelial ovarian cancer. The median follow-up of survivors from
initial surgery was 65 months (range, 27 to 132 months). Paraffin-embedded sections of primary tumour specimens were analysed
for IMD by immunohistochemistry using anti-CD34 antibodies. Results: Progression-free survival and overall survival were significantly
better in patients with IMD â¥40 microvessels/field compared with those with lower IMD (p=0.0105 and p=0.0065, respectively).
Cox model showed that IMD was the strongest independent prognostic variable for both progression-free survival (p=0.0267)
and overall survival (p=0.0189). Conclusion: An elevated IMD was associated with a significantly better progression-free survival
and overall survival in patients with stage III-IV epithelial ovarian cancer who underwent initial surgery followed by chemotherapy,
mainly consisting of a paclitaxel/platinum-based regimen. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_68131081</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68131081</sourcerecordid><originalsourceid>FETCH-LOGICAL-h270t-3b63183428a285a5139b40ce27191db6cc419ea6516f0bf83362a10215e4e76c3</originalsourceid><addsrcrecordid>eNpF0E1PwkAQBuCN0Qiif8HsRW9N9qO7bY-IqCQYPIjXZrodYHXb4m6L4d9bIobLzGGevJOZMzLkScajREl2ToZMKBYljKkBuQrhkzGts1RekgFPWBbHQg7J16xuPbRd1Xhw9NUa3-wwBHT0Eetg2z21NR2XO6gNlnS6te0Gne3pYgfeQk0nh4mnUJfUtoEuA1IIFOibb9Z1E1pr6MdBFg6vycUKXMCbYx-R5dP0ffISzRfPs8l4Hm1EwtpIFlryVMYiBZEqUFxmRcwMioRnvCy0MTHPELTiesWKVSqlFsCZ4ApjTLSRI3L_l7v1zXeHoc0rGww6BzU2Xch1yiVnfRmR2yPsigrLfOttBX6f_7-nB3dHAMGAW_n-WBtOLhWxiqU6bdzY9ebHesxDBc71sTIHL3SuHnKZCSV_AeCHe2s</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68131081</pqid></control><display><type>article</type><title>Intratumoral Microvessel Density in Advanced Epithelial Ovarian Cancer and its Use as a Prognostic Variable</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>GADDUCCI, Angiolo ; FERRERO, Annamaria ; GENAZZANI, Andrea Riccardo ; COSIO, Stefania ; ZOLA, Paolo ; VIACAVA, Paolo ; DOMPE, Daniela ; FANELLI, Giovanni ; RAVARINO, Nicoletta ; MOTTA, Manuela ; CRISTOFANI, Renza</creator><creatorcontrib>GADDUCCI, Angiolo ; FERRERO, Annamaria ; GENAZZANI, Andrea Riccardo ; COSIO, Stefania ; ZOLA, Paolo ; VIACAVA, Paolo ; DOMPE, Daniela ; FANELLI, Giovanni ; RAVARINO, Nicoletta ; MOTTA, Manuela ; CRISTOFANI, Renza</creatorcontrib><description>Background: The aim of this retrospective study was to assess whether the intratumoral microvessel density (IMD) in primary
tumour specimens had any impact on the clinical outcome of patients with advanced epithelial ovarian cancer treated in two
Italian departments of gynaecological oncology. Materials and Methods: The study was conducted on 101 patients who underwent
initial surgery followed by platinum-based chemotherapy (37) or paclitaxel/platinum-based chemotherapy (64) for International
Federation of Gynecology and Obstetrics (FIGO) stage III-IV epithelial ovarian cancer. The median follow-up of survivors from
initial surgery was 65 months (range, 27 to 132 months). Paraffin-embedded sections of primary tumour specimens were analysed
for IMD by immunohistochemistry using anti-CD34 antibodies. Results: Progression-free survival and overall survival were significantly
better in patients with IMD â¥40 microvessels/field compared with those with lower IMD (p=0.0105 and p=0.0065, respectively).
Cox model showed that IMD was the strongest independent prognostic variable for both progression-free survival (p=0.0267)
and overall survival (p=0.0189). Conclusion: An elevated IMD was associated with a significantly better progression-free survival
and overall survival in patients with stage III-IV epithelial ovarian cancer who underwent initial surgery followed by chemotherapy,
mainly consisting of a paclitaxel/platinum-based regimen.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 17094423</identifier><language>eng</language><publisher>Attiki: International Institute of Anticancer Research</publisher><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biological and medical sciences ; Combined Modality Therapy ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Humans ; Immunohistochemistry ; Medical sciences ; Middle Aged ; Neoplasms, Glandular and Epithelial - blood supply ; Neoplasms, Glandular and Epithelial - drug therapy ; Neoplasms, Glandular and Epithelial - pathology ; Neoplasms, Glandular and Epithelial - surgery ; Ovarian Neoplasms - blood supply ; Ovarian Neoplasms - drug therapy ; Ovarian Neoplasms - pathology ; Ovarian Neoplasms - surgery ; Prognosis ; Retrospective Studies ; Survival Analysis ; Tumors</subject><ispartof>Anticancer research, 2006-09, Vol.26 (5B), p.3925-3932</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18245435$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17094423$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GADDUCCI, Angiolo</creatorcontrib><creatorcontrib>FERRERO, Annamaria</creatorcontrib><creatorcontrib>GENAZZANI, Andrea Riccardo</creatorcontrib><creatorcontrib>COSIO, Stefania</creatorcontrib><creatorcontrib>ZOLA, Paolo</creatorcontrib><creatorcontrib>VIACAVA, Paolo</creatorcontrib><creatorcontrib>DOMPE, Daniela</creatorcontrib><creatorcontrib>FANELLI, Giovanni</creatorcontrib><creatorcontrib>RAVARINO, Nicoletta</creatorcontrib><creatorcontrib>MOTTA, Manuela</creatorcontrib><creatorcontrib>CRISTOFANI, Renza</creatorcontrib><title>Intratumoral Microvessel Density in Advanced Epithelial Ovarian Cancer and its Use as a Prognostic Variable</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Background: The aim of this retrospective study was to assess whether the intratumoral microvessel density (IMD) in primary
tumour specimens had any impact on the clinical outcome of patients with advanced epithelial ovarian cancer treated in two
Italian departments of gynaecological oncology. Materials and Methods: The study was conducted on 101 patients who underwent
initial surgery followed by platinum-based chemotherapy (37) or paclitaxel/platinum-based chemotherapy (64) for International
Federation of Gynecology and Obstetrics (FIGO) stage III-IV epithelial ovarian cancer. The median follow-up of survivors from
initial surgery was 65 months (range, 27 to 132 months). Paraffin-embedded sections of primary tumour specimens were analysed
for IMD by immunohistochemistry using anti-CD34 antibodies. Results: Progression-free survival and overall survival were significantly
better in patients with IMD â¥40 microvessels/field compared with those with lower IMD (p=0.0105 and p=0.0065, respectively).
Cox model showed that IMD was the strongest independent prognostic variable for both progression-free survival (p=0.0267)
and overall survival (p=0.0189). Conclusion: An elevated IMD was associated with a significantly better progression-free survival
and overall survival in patients with stage III-IV epithelial ovarian cancer who underwent initial surgery followed by chemotherapy,
mainly consisting of a paclitaxel/platinum-based regimen.</description><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Combined Modality Therapy</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasms, Glandular and Epithelial - blood supply</subject><subject>Neoplasms, Glandular and Epithelial - drug therapy</subject><subject>Neoplasms, Glandular and Epithelial - pathology</subject><subject>Neoplasms, Glandular and Epithelial - surgery</subject><subject>Ovarian Neoplasms - blood supply</subject><subject>Ovarian Neoplasms - drug therapy</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Ovarian Neoplasms - surgery</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Survival Analysis</subject><subject>Tumors</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0E1PwkAQBuCN0Qiif8HsRW9N9qO7bY-IqCQYPIjXZrodYHXb4m6L4d9bIobLzGGevJOZMzLkScajREl2ToZMKBYljKkBuQrhkzGts1RekgFPWBbHQg7J16xuPbRd1Xhw9NUa3-wwBHT0Eetg2z21NR2XO6gNlnS6te0Gne3pYgfeQk0nh4mnUJfUtoEuA1IIFOibb9Z1E1pr6MdBFg6vycUKXMCbYx-R5dP0ffISzRfPs8l4Hm1EwtpIFlryVMYiBZEqUFxmRcwMioRnvCy0MTHPELTiesWKVSqlFsCZ4ApjTLSRI3L_l7v1zXeHoc0rGww6BzU2Xch1yiVnfRmR2yPsigrLfOttBX6f_7-nB3dHAMGAW_n-WBtOLhWxiqU6bdzY9ebHesxDBc71sTIHL3SuHnKZCSV_AeCHe2s</recordid><startdate>20060901</startdate><enddate>20060901</enddate><creator>GADDUCCI, Angiolo</creator><creator>FERRERO, Annamaria</creator><creator>GENAZZANI, Andrea Riccardo</creator><creator>COSIO, Stefania</creator><creator>ZOLA, Paolo</creator><creator>VIACAVA, Paolo</creator><creator>DOMPE, Daniela</creator><creator>FANELLI, Giovanni</creator><creator>RAVARINO, Nicoletta</creator><creator>MOTTA, Manuela</creator><creator>CRISTOFANI, Renza</creator><general>International Institute of Anticancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20060901</creationdate><title>Intratumoral Microvessel Density in Advanced Epithelial Ovarian Cancer and its Use as a Prognostic Variable</title><author>GADDUCCI, Angiolo ; FERRERO, Annamaria ; GENAZZANI, Andrea Riccardo ; COSIO, Stefania ; ZOLA, Paolo ; VIACAVA, Paolo ; DOMPE, Daniela ; FANELLI, Giovanni ; RAVARINO, Nicoletta ; MOTTA, Manuela ; CRISTOFANI, Renza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h270t-3b63183428a285a5139b40ce27191db6cc419ea6516f0bf83362a10215e4e76c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Combined Modality Therapy</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasms, Glandular and Epithelial - blood supply</topic><topic>Neoplasms, Glandular and Epithelial - drug therapy</topic><topic>Neoplasms, Glandular and Epithelial - pathology</topic><topic>Neoplasms, Glandular and Epithelial - surgery</topic><topic>Ovarian Neoplasms - blood supply</topic><topic>Ovarian Neoplasms - drug therapy</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Ovarian Neoplasms - surgery</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Survival Analysis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GADDUCCI, Angiolo</creatorcontrib><creatorcontrib>FERRERO, Annamaria</creatorcontrib><creatorcontrib>GENAZZANI, Andrea Riccardo</creatorcontrib><creatorcontrib>COSIO, Stefania</creatorcontrib><creatorcontrib>ZOLA, Paolo</creatorcontrib><creatorcontrib>VIACAVA, Paolo</creatorcontrib><creatorcontrib>DOMPE, Daniela</creatorcontrib><creatorcontrib>FANELLI, Giovanni</creatorcontrib><creatorcontrib>RAVARINO, Nicoletta</creatorcontrib><creatorcontrib>MOTTA, Manuela</creatorcontrib><creatorcontrib>CRISTOFANI, Renza</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GADDUCCI, Angiolo</au><au>FERRERO, Annamaria</au><au>GENAZZANI, Andrea Riccardo</au><au>COSIO, Stefania</au><au>ZOLA, Paolo</au><au>VIACAVA, Paolo</au><au>DOMPE, Daniela</au><au>FANELLI, Giovanni</au><au>RAVARINO, Nicoletta</au><au>MOTTA, Manuela</au><au>CRISTOFANI, Renza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intratumoral Microvessel Density in Advanced Epithelial Ovarian Cancer and its Use as a Prognostic Variable</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2006-09-01</date><risdate>2006</risdate><volume>26</volume><issue>5B</issue><spage>3925</spage><epage>3932</epage><pages>3925-3932</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Background: The aim of this retrospective study was to assess whether the intratumoral microvessel density (IMD) in primary
tumour specimens had any impact on the clinical outcome of patients with advanced epithelial ovarian cancer treated in two
Italian departments of gynaecological oncology. Materials and Methods: The study was conducted on 101 patients who underwent
initial surgery followed by platinum-based chemotherapy (37) or paclitaxel/platinum-based chemotherapy (64) for International
Federation of Gynecology and Obstetrics (FIGO) stage III-IV epithelial ovarian cancer. The median follow-up of survivors from
initial surgery was 65 months (range, 27 to 132 months). Paraffin-embedded sections of primary tumour specimens were analysed
for IMD by immunohistochemistry using anti-CD34 antibodies. Results: Progression-free survival and overall survival were significantly
better in patients with IMD â¥40 microvessels/field compared with those with lower IMD (p=0.0105 and p=0.0065, respectively).
Cox model showed that IMD was the strongest independent prognostic variable for both progression-free survival (p=0.0267)
and overall survival (p=0.0189). Conclusion: An elevated IMD was associated with a significantly better progression-free survival
and overall survival in patients with stage III-IV epithelial ovarian cancer who underwent initial surgery followed by chemotherapy,
mainly consisting of a paclitaxel/platinum-based regimen.</abstract><cop>Attiki</cop><pub>International Institute of Anticancer Research</pub><pmid>17094423</pmid><tpages>8</tpages></addata></record> |
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| issn | 0250-7005 1791-7530 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Combined Modality Therapy Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Medical sciences Middle Aged Neoplasms, Glandular and Epithelial - blood supply Neoplasms, Glandular and Epithelial - drug therapy Neoplasms, Glandular and Epithelial - pathology Neoplasms, Glandular and Epithelial - surgery Ovarian Neoplasms - blood supply Ovarian Neoplasms - drug therapy Ovarian Neoplasms - pathology Ovarian Neoplasms - surgery Prognosis Retrospective Studies Survival Analysis Tumors |
| title | Intratumoral Microvessel Density in Advanced Epithelial Ovarian Cancer and its Use as a Prognostic Variable |
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