Bacterial contingency loci: the role of simple sequence DNA repeats in bacterial adaptation
Bacterial pathogens face stringent challenges to their survival because of the many unpredictable, often precipitate, and dynamic changes that occur in the host environment or in the process of transmission from one host to another. Bacterial adaptation to their hosts involves either a mechanism for...
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| Veröffentlicht in: | Annual review of genetics 2006-01, Vol.40 (1), p.307-333 |
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| container_title | Annual review of genetics |
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| creator | Moxon, Richard Bayliss, Chris Hood, Derek |
| description | Bacterial pathogens face stringent challenges to their survival because of the many unpredictable, often precipitate, and dynamic changes that occur in the host environment or in the process of transmission from one host to another. Bacterial adaptation to their hosts involves either a mechanism for sensing and responding to external changes or the selection of variants that arise through mutation. Here we review how bacterial pathogens exploit localized hypermutation, through polymerase slippage of simple sequence repeats (SSRs), to generate phenotypic variation and enhanced fitness. These SSRs are located within the reading frame or in the promoter of a subset of genes, often termed contingency loci, whose functions are usually involved in direct interactions with host structures. |
| doi_str_mv | 10.1146/annurev.genet.40.110405.090442 |
| format | Article |
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| ispartof | Annual review of genetics, 2006-01, Vol.40 (1), p.307-333 |
| issn | 0066-4197 1545-2948 |
| language | eng |
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| source | Annual Reviews; MEDLINE |
| subjects | Adaptation, Physiological Bacteria Base Sequence Deoxyribonucleic acid DNA DNA, Bacterial - chemistry DNA, Bacterial - metabolism Genes, Bacterial Genetic Variation Genetics Genotype & phenotype Haemophilus influenzae - genetics Haemophilus influenzae - metabolism Haemophilus influenzae - pathogenicity Microsatellite Repeats Molecular Sequence Data Mutation Open Reading Frames Pathogens Phenotype Phenotypic variations |
| title | Bacterial contingency loci: the role of simple sequence DNA repeats in bacterial adaptation |
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