The Localization and Activity of Sphingosine Kinase 1 Are Coordinately Regulated with Actin Cytoskeletal Dynamics in Macrophages

The physiologic and pathologic functions of sphingosine kinase (SK) require translocation to specific membrane compartments. We tested the hypothesis that interactions with actin filaments regulate the localization of SK1 to membrane surfaces, including the plasma membrane and phagosome. Macrophage...

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Veröffentlicht in:	The Journal of biological chemistry 2007-08, Vol.282 (32), p.23147-23162
Hauptverfasser:	Kusner, David J., Thompson, Christopher R., Melrose, Natalie A., Pitson, Stuart M., Obeid, Lina M., Iyer, Shankar S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Animals Catalysis Cell Membrane - metabolism Cytoskeleton - metabolism Gene Expression Regulation, Enzymologic Green Fluorescent Proteins - metabolism Humans Macrophages - metabolism Mice Models, Biological Phagosomes - metabolism Phosphotransferases (Alcohol Group Acceptor) - biosynthesis Phosphotransferases (Alcohol Group Acceptor) - physiology Protein Transport
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