Muscarinic acetylcholine receptor status in Alzheimer's disease assessed using (R, R) 123I-QNB SPECT

One of the most characteristic changes in Alzheimer's disease (AD) is a deficit in cortical cholinergic neurotransmission and associated receptor changes. To investigate differences in the distribution of M1/M4 receptors using (R, R) (123)I-iodo-quinuclidinyl-benzilate (QNB) and single photon e...

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Veröffentlicht in:	Journal of neurology 2007-07, Vol.254 (7), p.907-913
Hauptverfasser:	PAKRASI, Sanjeet, COLLOBY, Sean J, FIRBANK, Michael J, PERRY, Elaine K, WYPER, David J, OWENS, Jonathan, MCKEITH, Ian G, WILLIAMS, E. David, O'BRIEN, John T
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - diagnostic imaging Alzheimer Disease - metabolism Alzheimer's disease Biological and medical sciences Brain Mapping Brain research Clinics Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Hospitals Humans Iodine Radioisotopes Male Medical sciences Nervous system (semeiology, syndromes) Neurology Quinuclidinyl Benzilate - analogs & derivatives Receptors, Muscarinic - metabolism Regions Tomography Tomography, Emission-Computed, Single-Photon - methods
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