Cutting Edge: The ST2 Ligand IL-33 Potently Activates and Drives Maturation of Human Mast Cells

IL-33, the natural ligand of the IL-1 receptor family member ST2L, is known to enhance experimental allergic-type inflammatory responses by costimulating the production of cytokines from activated Th2 lymphocytes. Although ST2L has long been known to be expressed by mast cells, its role in their bio...

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Veröffentlicht in:	Journal of Immunology 2007-08, Vol.179 (4), p.2051-2054
Hauptverfasser:	Allakhverdi, Zoulfia, Smith, Dirk E, Comeau, Michael R, Delespesse, Guy
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells, Cultured Chemokines - immunology Chemokines - metabolism Humans Hypersensitivity - immunology Hypersensitivity - metabolism Immunity, Innate - drug effects Inflammation - immunology Inflammation - metabolism Interleukin-1 Receptor-Like 1 Protein Interleukin-33 Interleukins - immunology Interleukins - pharmacology Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Mast Cells - immunology Mast Cells - metabolism Receptors, Cell Surface - immunology Receptors, Cell Surface - metabolism Stem Cells - immunology Stem Cells - metabolism Th2 Cells - immunology Th2 Cells - metabolism
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