The relationship between homocysteine, cognition and stroke subtypes in acute stroke
Elevations in plasma homocysteine (Hcy) have been associated with an increased risk of stroke and dementia. The mechanisms underlying these associations remain poorly understood. This study examines the relationships between Hcy, cognition, and stroke subtype. We hypothesize that: 1) Hcy levels are...
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| Veröffentlicht in: | Journal of the neurological sciences 2006-12, Vol.250 (1), p.58-61 |
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| creator | Tay, S.Y. Ampil, E.R. Chen, C.P.L.H. Auchus, A.P. |
| description | Elevations in plasma homocysteine (Hcy) have been associated with an increased risk of stroke and dementia. The mechanisms underlying these associations remain poorly understood.
This study examines the relationships between Hcy, cognition, and stroke subtype. We hypothesize that: 1) Hcy levels are inversely related to cognition, 2) Hcy levels are unrelated to stroke subtype, and 3) stroke subtype affects cognition.
We studied 169 consenting patients admitted for acute stroke during a 4 month period. Blood was drawn for Hcy levels and the Mini-Mental State Examination (MMSE) was administered within 9 days of admission. The Oxfordshire Community Stroke Project Classification was used to characterize stroke subtypes. Correlation between Hcy and MMSE scores was examined as was the relationships between Hcy and stroke subtype, and between stroke subtypes and MMSE scores.
A significant inverse correlation between Hcy levels and MMSE scores was demonstrated (
r
=
−
0.243,
p
=
0.001). MMSE scores also differed according to the type of stroke, with Total or Partial Anterior Circulation Infarcts (TACI/PACI) scoring lowest (
F
=
8.77,
df
=
2,
p
<
0.001). Hcy levels did not differ between the various stroke subtypes (
F
=
0.21,
df
=
2,
p
=
0.81). Multivariate linear regression analysis showed that age, education, and stroke subtype, but not Hcy, were independent predictors of acute MMSE scores.
In this study sample, there was an inverse relationship between Hcy and cognition in acute stroke patients. However, Hcy was not an independent predictor for cognition in acute stroke after other factors such as stroke subtype and patient age were taken into account. These results suggest that during the acute stage of stroke, stroke subtype is a more important factor in determining cognition than Hcy levels. |
| doi_str_mv | 10.1016/j.jns.2006.06.028 |
| format | Article |
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This study examines the relationships between Hcy, cognition, and stroke subtype. We hypothesize that: 1) Hcy levels are inversely related to cognition, 2) Hcy levels are unrelated to stroke subtype, and 3) stroke subtype affects cognition.
We studied 169 consenting patients admitted for acute stroke during a 4 month period. Blood was drawn for Hcy levels and the Mini-Mental State Examination (MMSE) was administered within 9 days of admission. The Oxfordshire Community Stroke Project Classification was used to characterize stroke subtypes. Correlation between Hcy and MMSE scores was examined as was the relationships between Hcy and stroke subtype, and between stroke subtypes and MMSE scores.
A significant inverse correlation between Hcy levels and MMSE scores was demonstrated (
r
=
−
0.243,
p
=
0.001). MMSE scores also differed according to the type of stroke, with Total or Partial Anterior Circulation Infarcts (TACI/PACI) scoring lowest (
F
=
8.77,
df
=
2,
p
<
0.001). Hcy levels did not differ between the various stroke subtypes (
F
=
0.21,
df
=
2,
p
=
0.81). Multivariate linear regression analysis showed that age, education, and stroke subtype, but not Hcy, were independent predictors of acute MMSE scores.
In this study sample, there was an inverse relationship between Hcy and cognition in acute stroke patients. However, Hcy was not an independent predictor for cognition in acute stroke after other factors such as stroke subtype and patient age were taken into account. These results suggest that during the acute stage of stroke, stroke subtype is a more important factor in determining cognition than Hcy levels.</description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/j.jns.2006.06.028</identifier><identifier>PMID: 16935307</identifier><identifier>CODEN: JNSCAG</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Acute Disease ; Aged ; Biological and medical sciences ; Blood. Blood coagulation. Reticuloendothelial system ; Brain - blood supply ; Brain - metabolism ; Brain - physiopathology ; Brain Infarction - blood ; Brain Infarction - physiopathology ; Cerebral Arteries - metabolism ; Cerebral Arteries - physiopathology ; Cerebrovascular Circulation - physiology ; Cognition ; Cognition - physiology ; Cognition Disorders - blood ; Cognition Disorders - etiology ; Cognition Disorders - physiopathology ; Dementia ; Female ; Homocysteine ; Homocysteine - blood ; Humans ; Male ; Medical sciences ; Middle Aged ; MMSE ; Neurology ; Neuropsychological Tests ; Pharmacology. Drug treatments ; Predictive Value of Tests ; Statistics as Topic ; Stroke ; Stroke - blood ; Stroke - classification ; Stroke - physiopathology ; Stroke subtype ; Up-Regulation - physiology ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Journal of the neurological sciences, 2006-12, Vol.250 (1), p.58-61</ispartof><rights>2006 Elsevier B.V.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-3ead5ae709746d9c5b97c7acc01c76cfc95fd520b919c3717a011cc442d3c8383</citedby><cites>FETCH-LOGICAL-c381t-3ead5ae709746d9c5b97c7acc01c76cfc95fd520b919c3717a011cc442d3c8383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022510X0600311X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18284509$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16935307$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tay, S.Y.</creatorcontrib><creatorcontrib>Ampil, E.R.</creatorcontrib><creatorcontrib>Chen, C.P.L.H.</creatorcontrib><creatorcontrib>Auchus, A.P.</creatorcontrib><title>The relationship between homocysteine, cognition and stroke subtypes in acute stroke</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description>Elevations in plasma homocysteine (Hcy) have been associated with an increased risk of stroke and dementia. The mechanisms underlying these associations remain poorly understood.
This study examines the relationships between Hcy, cognition, and stroke subtype. We hypothesize that: 1) Hcy levels are inversely related to cognition, 2) Hcy levels are unrelated to stroke subtype, and 3) stroke subtype affects cognition.
We studied 169 consenting patients admitted for acute stroke during a 4 month period. Blood was drawn for Hcy levels and the Mini-Mental State Examination (MMSE) was administered within 9 days of admission. The Oxfordshire Community Stroke Project Classification was used to characterize stroke subtypes. Correlation between Hcy and MMSE scores was examined as was the relationships between Hcy and stroke subtype, and between stroke subtypes and MMSE scores.
A significant inverse correlation between Hcy levels and MMSE scores was demonstrated (
r
=
−
0.243,
p
=
0.001). MMSE scores also differed according to the type of stroke, with Total or Partial Anterior Circulation Infarcts (TACI/PACI) scoring lowest (
F
=
8.77,
df
=
2,
p
<
0.001). Hcy levels did not differ between the various stroke subtypes (
F
=
0.21,
df
=
2,
p
=
0.81). Multivariate linear regression analysis showed that age, education, and stroke subtype, but not Hcy, were independent predictors of acute MMSE scores.
In this study sample, there was an inverse relationship between Hcy and cognition in acute stroke patients. However, Hcy was not an independent predictor for cognition in acute stroke after other factors such as stroke subtype and patient age were taken into account. These results suggest that during the acute stage of stroke, stroke subtype is a more important factor in determining cognition than Hcy levels.</description><subject>Acute Disease</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blood. Blood coagulation. Reticuloendothelial system</subject><subject>Brain - blood supply</subject><subject>Brain - metabolism</subject><subject>Brain - physiopathology</subject><subject>Brain Infarction - blood</subject><subject>Brain Infarction - physiopathology</subject><subject>Cerebral Arteries - metabolism</subject><subject>Cerebral Arteries - physiopathology</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>Cognition</subject><subject>Cognition - physiology</subject><subject>Cognition Disorders - blood</subject><subject>Cognition Disorders - etiology</subject><subject>Cognition Disorders - physiopathology</subject><subject>Dementia</subject><subject>Female</subject><subject>Homocysteine</subject><subject>Homocysteine - blood</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>MMSE</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Pharmacology. Drug treatments</subject><subject>Predictive Value of Tests</subject><subject>Statistics as Topic</subject><subject>Stroke</subject><subject>Stroke - blood</subject><subject>Stroke - classification</subject><subject>Stroke - physiopathology</subject><subject>Stroke subtype</subject><subject>Up-Regulation - physiology</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1q3DAURkVpaKZJHqCb4k2zqqf6GVkSXZWQNoVANlPoTsjX1x1NPdJUklvm7WszhuwCHwiko-9eDiHvGF0zyppP-_U-5DWntFnP4foVWTGtdC21Fq_JilLOa8noz0vyNuc9nUCtzRtyyRojpKBqRbbbHVYJB1d8DHnnj1WL5R9iqHbxEOGUC_qAHyuIv4KfmcqFrsolxd9Y5bEtpyPmyk_XMBZcHq7JRe-GjDfLeUV-fL3f3j3Uj0_fvt99eaxBaFZqga6TDhU1atN0BmRrFCgHQBmoBnowsu8kp61hBoRiylHGADYb3gnQQosrcnvuPab4Z8Rc7MFnwGFwAeOYbaMZbxppJpCdQUgx54S9PSZ_cOlkGbWzSru3k0o7q7Rz-Fz-fikf2wN2zz8WdxPwYQFcBjf0yQXw-ZnTXG8knYd_PnM4qfjrMdkMHgNg5xNCsV30L6zxH8TGkpU</recordid><startdate>20061201</startdate><enddate>20061201</enddate><creator>Tay, S.Y.</creator><creator>Ampil, E.R.</creator><creator>Chen, C.P.L.H.</creator><creator>Auchus, A.P.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20061201</creationdate><title>The relationship between homocysteine, cognition and stroke subtypes in acute stroke</title><author>Tay, S.Y. ; Ampil, E.R. ; Chen, C.P.L.H. ; Auchus, A.P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-3ead5ae709746d9c5b97c7acc01c76cfc95fd520b919c3717a011cc442d3c8383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Acute Disease</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Blood. Blood coagulation. Reticuloendothelial system</topic><topic>Brain - blood supply</topic><topic>Brain - metabolism</topic><topic>Brain - physiopathology</topic><topic>Brain Infarction - blood</topic><topic>Brain Infarction - physiopathology</topic><topic>Cerebral Arteries - metabolism</topic><topic>Cerebral Arteries - physiopathology</topic><topic>Cerebrovascular Circulation - physiology</topic><topic>Cognition</topic><topic>Cognition - physiology</topic><topic>Cognition Disorders - blood</topic><topic>Cognition Disorders - etiology</topic><topic>Cognition Disorders - physiopathology</topic><topic>Dementia</topic><topic>Female</topic><topic>Homocysteine</topic><topic>Homocysteine - blood</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>MMSE</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Pharmacology. Drug treatments</topic><topic>Predictive Value of Tests</topic><topic>Statistics as Topic</topic><topic>Stroke</topic><topic>Stroke - blood</topic><topic>Stroke - classification</topic><topic>Stroke - physiopathology</topic><topic>Stroke subtype</topic><topic>Up-Regulation - physiology</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tay, S.Y.</creatorcontrib><creatorcontrib>Ampil, E.R.</creatorcontrib><creatorcontrib>Chen, C.P.L.H.</creatorcontrib><creatorcontrib>Auchus, A.P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tay, S.Y.</au><au>Ampil, E.R.</au><au>Chen, C.P.L.H.</au><au>Auchus, A.P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationship between homocysteine, cognition and stroke subtypes in acute stroke</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>2006-12-01</date><risdate>2006</risdate><volume>250</volume><issue>1</issue><spage>58</spage><epage>61</epage><pages>58-61</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><coden>JNSCAG</coden><abstract>Elevations in plasma homocysteine (Hcy) have been associated with an increased risk of stroke and dementia. The mechanisms underlying these associations remain poorly understood.
This study examines the relationships between Hcy, cognition, and stroke subtype. We hypothesize that: 1) Hcy levels are inversely related to cognition, 2) Hcy levels are unrelated to stroke subtype, and 3) stroke subtype affects cognition.
We studied 169 consenting patients admitted for acute stroke during a 4 month period. Blood was drawn for Hcy levels and the Mini-Mental State Examination (MMSE) was administered within 9 days of admission. The Oxfordshire Community Stroke Project Classification was used to characterize stroke subtypes. Correlation between Hcy and MMSE scores was examined as was the relationships between Hcy and stroke subtype, and between stroke subtypes and MMSE scores.
A significant inverse correlation between Hcy levels and MMSE scores was demonstrated (
r
=
−
0.243,
p
=
0.001). MMSE scores also differed according to the type of stroke, with Total or Partial Anterior Circulation Infarcts (TACI/PACI) scoring lowest (
F
=
8.77,
df
=
2,
p
<
0.001). Hcy levels did not differ between the various stroke subtypes (
F
=
0.21,
df
=
2,
p
=
0.81). Multivariate linear regression analysis showed that age, education, and stroke subtype, but not Hcy, were independent predictors of acute MMSE scores.
In this study sample, there was an inverse relationship between Hcy and cognition in acute stroke patients. However, Hcy was not an independent predictor for cognition in acute stroke after other factors such as stroke subtype and patient age were taken into account. These results suggest that during the acute stage of stroke, stroke subtype is a more important factor in determining cognition than Hcy levels.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>16935307</pmid><doi>10.1016/j.jns.2006.06.028</doi><tpages>4</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acute Disease Aged Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Brain - blood supply Brain - metabolism Brain - physiopathology Brain Infarction - blood Brain Infarction - physiopathology Cerebral Arteries - metabolism Cerebral Arteries - physiopathology Cerebrovascular Circulation - physiology Cognition Cognition - physiology Cognition Disorders - blood Cognition Disorders - etiology Cognition Disorders - physiopathology Dementia Female Homocysteine Homocysteine - blood Humans Male Medical sciences Middle Aged MMSE Neurology Neuropsychological Tests Pharmacology. Drug treatments Predictive Value of Tests Statistics as Topic Stroke Stroke - blood Stroke - classification Stroke - physiopathology Stroke subtype Up-Regulation - physiology Vascular diseases and vascular malformations of the nervous system |
| title | The relationship between homocysteine, cognition and stroke subtypes in acute stroke |
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