The reverse transcriptase 67N 70R 215Y genotype is the predominant TAM pathway associated with virologic failure among HIV type 1C-infected adults treated with ZDV/ddi-containing HAART in southern africa

HIV-1C has become the dominant HIV-1 subtype in the global AIDS epidemic. Historically, the evolution of drug-resistant mutations was characterized primarily among antiretroviral (ARV)-treated HIV-1B infections. Whereas the non-B viruses are susceptible to the currently used ARVs, some differences b...

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Veröffentlicht in:	AIDS research and human retroviruses 2007-07, Vol.23 (7), p.868-878
Hauptverfasser:	NOVITSKY, Vlad, WESTER, C. William, ESSEX, M, DEGRUTTOLA, Victor, BUSSMANN, Hermann, GASEITSIWE, Simani, THOMAS, Ann, MOYO, Sikhulile, MUSONDA, Rosemary, VAN WIDENFELT, Erik, MARLINK, Richard G
Format:	Artikel
Sprache:	eng
Schlagworte:	Africa, Southern AIDS/HIV Antiretroviral Therapy, Highly Active Biological and medical sciences Didanosine - pharmacology Drug Resistance, Multiple, Viral - genetics Evolution, Molecular Female Fundamental and applied biological sciences. Psychology Genotype HIV Infections - drug therapy HIV-1 - drug effects HIV-1 - genetics Human immunodeficiency virus 1 Human viral diseases Humans Infectious diseases Male Medical sciences Microbiology Miscellaneous Molecular Sequence Data Mutation - genetics Reverse Transcriptase Inhibitors - pharmacology RNA-Directed DNA Polymerase - genetics Thymidine - analogs & derivatives Thymidine - genetics Treatment Failure Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Virology Zidovudine - pharmacology
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