Circulating recombinant form (CRF) 37_cpx : An old strain in cameroon composed of diverse, genetically distant lineages of subtypes A and G
HIV-1 in Cameroon is genetically diverse, but is predominated by the circulating recombinant form (CRF) 02_AG, which cocirculates among an array of other CRFs, unique recombinant forms (URFs), and all group M subtypes. In particular, our studies of HIV-1 diversity in the East Province found a high p...
Gespeichert in:
| Veröffentlicht in: | AIDS research and human retroviruses 2007-07, Vol.23 (7), p.923-933 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 933 |
|---|---|
| container_issue | 7 |
| container_start_page | 923 |
| container_title | AIDS research and human retroviruses |
| container_volume | 23 |
| creator | POWELL, Rebecca L. R JIANGQIN ZHAO KONINGS, Frank A. J SHIXING TANG EWANE, Leonard BURDA, Sherri URBANSKI, Mateusz M SAA, D. R HEWLETT, Indira NYAMBI, Phillipe N |
| description | HIV-1 in Cameroon is genetically diverse, but is predominated by the circulating recombinant form (CRF) 02_AG, which cocirculates among an array of other CRFs, unique recombinant forms (URFs), and all group M subtypes. In particular, our studies of HIV-1 diversity in the East Province found a high proportion of URFs and second generation recombinants (SGRs), suggesting this region of Cameroon may be a breading ground for new CRFs. Herein we present the full-length sequence analysis of one such CRF, composed primarily (66%) of unique, distant lineages of subtypes A and G in alternating regions throughout the genome. This CRF also combines segments in pol and env genes possessing intrasubtype distance ( |
| doi_str_mv | 10.1089/aid.2007.0040 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_68124569</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A191647080</galeid><sourcerecordid>A191647080</sourcerecordid><originalsourceid>FETCH-LOGICAL-c380t-a6a9ed29471da960c1b6f47de7fbc54e069d26ce72c32687e469a9f6671cac153</originalsourceid><addsrcrecordid>eNqF0U2LFDEQBuAgijuuHr1KQBQFe0zS6Xx4GwZ3FRYE0XNIJ9VDpDsZk25xfoN_2rQzsEehIEV4qIJ6EXpOyZYSpd_b4LeMELklhJMHaEN1SxvFSfcQbYhSumGM6Sv0pJQfhBDNWPcYXVEppOJSbtCffchuGe0c4gFncGnqQ7RxxkPKE36z_3rzFrfSuONv_AHvIk6jx2XONkRcy9kJckq1SdMxFfA4DdiHX5ALvMMHiDAHZ8fxVD_LvI4dQwR7gLLCsvTz6Vj7HbbR49un6NFgxwLPLu81-n7z8dv-U3P35fbzfnfXuFaRubHCavBMc0m91YI42ouBSw9y6F3HgQjtmXAgmWuZUBK40FYPQkjqrKNde41en-cec_q5QJnNFIqDcbQR0lKMUJTxTuj_QkZY19F_8OUZHuwIJsQh1RO5FZsd1VRwSRSpqjkrl1MpGQZzzGGy-WQoMWuYpoZp1jDNGmb1Ly7rl34Cf68v6VXw6gJsqWceso0ulHuntGSC8vYv_PCmbQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20255169</pqid></control><display><type>article</type><title>Circulating recombinant form (CRF) 37_cpx : An old strain in cameroon composed of diverse, genetically distant lineages of subtypes A and G</title><source>Mary Ann Liebert Online Subscription</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>POWELL, Rebecca L. R ; JIANGQIN ZHAO ; KONINGS, Frank A. J ; SHIXING TANG ; EWANE, Leonard ; BURDA, Sherri ; URBANSKI, Mateusz M ; SAA, D. R ; HEWLETT, Indira ; NYAMBI, Phillipe N</creator><creatorcontrib>POWELL, Rebecca L. R ; JIANGQIN ZHAO ; KONINGS, Frank A. J ; SHIXING TANG ; EWANE, Leonard ; BURDA, Sherri ; URBANSKI, Mateusz M ; SAA, D. R ; HEWLETT, Indira ; NYAMBI, Phillipe N</creatorcontrib><description>HIV-1 in Cameroon is genetically diverse, but is predominated by the circulating recombinant form (CRF) 02_AG, which cocirculates among an array of other CRFs, unique recombinant forms (URFs), and all group M subtypes. In particular, our studies of HIV-1 diversity in the East Province found a high proportion of URFs and second generation recombinants (SGRs), suggesting this region of Cameroon may be a breading ground for new CRFs. Herein we present the full-length sequence analysis of one such CRF, composed primarily (66%) of unique, distant lineages of subtypes A and G in alternating regions throughout the genome. This CRF also combines segments in pol and env genes possessing intrasubtype distance (<15%) to the CRF01_AE and CRF02_AG radiations. The genomic composition of this strain comprising gene segments of subtypes A and G as well as CRF01_AE and CRF02_AG defines this strain as a circulating SGR (CSGR), and the 37th CRF to be identified. Furthermore, more than half of CRF19_cpx, a CRF identified in Cuba, clusters with CRF37_cpx, and the clear genetic distance among the viruses in this cluster suggests this strain has been in circulation since the early days of the epidemic. The genetically distant segments comprising CRF37_cpx, which were found to cluster outside the crown groups of previously described viruses, may represent a link to very rare or extinct strains, and, potentially, to understanding the evolutionary history of HIV-1 in this region.</description><identifier>ISSN: 0889-2229</identifier><identifier>EISSN: 1931-8405</identifier><identifier>DOI: 10.1089/aid.2007.0040</identifier><identifier>PMID: 17678477</identifier><identifier>CODEN: ARHRE7</identifier><language>eng</language><publisher>Larchmont, NY: Liebert</publisher><subject>AIDS/HIV ; Biological and medical sciences ; Biological diversity ; Cameroon - epidemiology ; Distribution ; Evolution, Molecular ; Fundamental and applied biological sciences. Psychology ; Genetic aspects ; Health aspects ; HIV (Viruses) ; HIV Infections - epidemiology ; HIV Infections - genetics ; HIV-1 - classification ; HIV-1 - genetics ; Human immunodeficiency virus 1 ; Human viral diseases ; Humans ; Infectious diseases ; Medical sciences ; Microbiology ; Miscellaneous ; Molecular Sequence Data ; Phylogeny ; Recombination, Genetic ; Retrovirus ; Viral diseases ; Virology</subject><ispartof>AIDS research and human retroviruses, 2007-07, Vol.23 (7), p.923-933</ispartof><rights>2007 INIST-CNRS</rights><rights>COPYRIGHT 2007 Mary Ann Liebert, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c380t-a6a9ed29471da960c1b6f47de7fbc54e069d26ce72c32687e469a9f6671cac153</citedby><cites>FETCH-LOGICAL-c380t-a6a9ed29471da960c1b6f47de7fbc54e069d26ce72c32687e469a9f6671cac153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3029,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18972614$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17678477$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>POWELL, Rebecca L. R</creatorcontrib><creatorcontrib>JIANGQIN ZHAO</creatorcontrib><creatorcontrib>KONINGS, Frank A. J</creatorcontrib><creatorcontrib>SHIXING TANG</creatorcontrib><creatorcontrib>EWANE, Leonard</creatorcontrib><creatorcontrib>BURDA, Sherri</creatorcontrib><creatorcontrib>URBANSKI, Mateusz M</creatorcontrib><creatorcontrib>SAA, D. R</creatorcontrib><creatorcontrib>HEWLETT, Indira</creatorcontrib><creatorcontrib>NYAMBI, Phillipe N</creatorcontrib><title>Circulating recombinant form (CRF) 37_cpx : An old strain in cameroon composed of diverse, genetically distant lineages of subtypes A and G</title><title>AIDS research and human retroviruses</title><addtitle>AIDS Res Hum Retroviruses</addtitle><description>HIV-1 in Cameroon is genetically diverse, but is predominated by the circulating recombinant form (CRF) 02_AG, which cocirculates among an array of other CRFs, unique recombinant forms (URFs), and all group M subtypes. In particular, our studies of HIV-1 diversity in the East Province found a high proportion of URFs and second generation recombinants (SGRs), suggesting this region of Cameroon may be a breading ground for new CRFs. Herein we present the full-length sequence analysis of one such CRF, composed primarily (66%) of unique, distant lineages of subtypes A and G in alternating regions throughout the genome. This CRF also combines segments in pol and env genes possessing intrasubtype distance (<15%) to the CRF01_AE and CRF02_AG radiations. The genomic composition of this strain comprising gene segments of subtypes A and G as well as CRF01_AE and CRF02_AG defines this strain as a circulating SGR (CSGR), and the 37th CRF to be identified. Furthermore, more than half of CRF19_cpx, a CRF identified in Cuba, clusters with CRF37_cpx, and the clear genetic distance among the viruses in this cluster suggests this strain has been in circulation since the early days of the epidemic. The genetically distant segments comprising CRF37_cpx, which were found to cluster outside the crown groups of previously described viruses, may represent a link to very rare or extinct strains, and, potentially, to understanding the evolutionary history of HIV-1 in this region.</description><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>Biological diversity</subject><subject>Cameroon - epidemiology</subject><subject>Distribution</subject><subject>Evolution, Molecular</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>HIV (Viruses)</subject><subject>HIV Infections - epidemiology</subject><subject>HIV Infections - genetics</subject><subject>HIV-1 - classification</subject><subject>HIV-1 - genetics</subject><subject>Human immunodeficiency virus 1</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Molecular Sequence Data</subject><subject>Phylogeny</subject><subject>Recombination, Genetic</subject><subject>Retrovirus</subject><subject>Viral diseases</subject><subject>Virology</subject><issn>0889-2229</issn><issn>1931-8405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U2LFDEQBuAgijuuHr1KQBQFe0zS6Xx4GwZ3FRYE0XNIJ9VDpDsZk25xfoN_2rQzsEehIEV4qIJ6EXpOyZYSpd_b4LeMELklhJMHaEN1SxvFSfcQbYhSumGM6Sv0pJQfhBDNWPcYXVEppOJSbtCffchuGe0c4gFncGnqQ7RxxkPKE36z_3rzFrfSuONv_AHvIk6jx2XONkRcy9kJckq1SdMxFfA4DdiHX5ALvMMHiDAHZ8fxVD_LvI4dQwR7gLLCsvTz6Vj7HbbR49un6NFgxwLPLu81-n7z8dv-U3P35fbzfnfXuFaRubHCavBMc0m91YI42ouBSw9y6F3HgQjtmXAgmWuZUBK40FYPQkjqrKNde41en-cec_q5QJnNFIqDcbQR0lKMUJTxTuj_QkZY19F_8OUZHuwIJsQh1RO5FZsd1VRwSRSpqjkrl1MpGQZzzGGy-WQoMWuYpoZp1jDNGmb1Ly7rl34Cf68v6VXw6gJsqWceso0ulHuntGSC8vYv_PCmbQ</recordid><startdate>20070701</startdate><enddate>20070701</enddate><creator>POWELL, Rebecca L. R</creator><creator>JIANGQIN ZHAO</creator><creator>KONINGS, Frank A. J</creator><creator>SHIXING TANG</creator><creator>EWANE, Leonard</creator><creator>BURDA, Sherri</creator><creator>URBANSKI, Mateusz M</creator><creator>SAA, D. R</creator><creator>HEWLETT, Indira</creator><creator>NYAMBI, Phillipe N</creator><general>Liebert</general><general>Mary Ann Liebert, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20070701</creationdate><title>Circulating recombinant form (CRF) 37_cpx : An old strain in cameroon composed of diverse, genetically distant lineages of subtypes A and G</title><author>POWELL, Rebecca L. R ; JIANGQIN ZHAO ; KONINGS, Frank A. J ; SHIXING TANG ; EWANE, Leonard ; BURDA, Sherri ; URBANSKI, Mateusz M ; SAA, D. R ; HEWLETT, Indira ; NYAMBI, Phillipe N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-a6a9ed29471da960c1b6f47de7fbc54e069d26ce72c32687e469a9f6671cac153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>Biological diversity</topic><topic>Cameroon - epidemiology</topic><topic>Distribution</topic><topic>Evolution, Molecular</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>HIV (Viruses)</topic><topic>HIV Infections - epidemiology</topic><topic>HIV Infections - genetics</topic><topic>HIV-1 - classification</topic><topic>HIV-1 - genetics</topic><topic>Human immunodeficiency virus 1</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Molecular Sequence Data</topic><topic>Phylogeny</topic><topic>Recombination, Genetic</topic><topic>Retrovirus</topic><topic>Viral diseases</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>POWELL, Rebecca L. R</creatorcontrib><creatorcontrib>JIANGQIN ZHAO</creatorcontrib><creatorcontrib>KONINGS, Frank A. J</creatorcontrib><creatorcontrib>SHIXING TANG</creatorcontrib><creatorcontrib>EWANE, Leonard</creatorcontrib><creatorcontrib>BURDA, Sherri</creatorcontrib><creatorcontrib>URBANSKI, Mateusz M</creatorcontrib><creatorcontrib>SAA, D. R</creatorcontrib><creatorcontrib>HEWLETT, Indira</creatorcontrib><creatorcontrib>NYAMBI, Phillipe N</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>AIDS research and human retroviruses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>POWELL, Rebecca L. R</au><au>JIANGQIN ZHAO</au><au>KONINGS, Frank A. J</au><au>SHIXING TANG</au><au>EWANE, Leonard</au><au>BURDA, Sherri</au><au>URBANSKI, Mateusz M</au><au>SAA, D. R</au><au>HEWLETT, Indira</au><au>NYAMBI, Phillipe N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating recombinant form (CRF) 37_cpx : An old strain in cameroon composed of diverse, genetically distant lineages of subtypes A and G</atitle><jtitle>AIDS research and human retroviruses</jtitle><addtitle>AIDS Res Hum Retroviruses</addtitle><date>2007-07-01</date><risdate>2007</risdate><volume>23</volume><issue>7</issue><spage>923</spage><epage>933</epage><pages>923-933</pages><issn>0889-2229</issn><eissn>1931-8405</eissn><coden>ARHRE7</coden><abstract>HIV-1 in Cameroon is genetically diverse, but is predominated by the circulating recombinant form (CRF) 02_AG, which cocirculates among an array of other CRFs, unique recombinant forms (URFs), and all group M subtypes. In particular, our studies of HIV-1 diversity in the East Province found a high proportion of URFs and second generation recombinants (SGRs), suggesting this region of Cameroon may be a breading ground for new CRFs. Herein we present the full-length sequence analysis of one such CRF, composed primarily (66%) of unique, distant lineages of subtypes A and G in alternating regions throughout the genome. This CRF also combines segments in pol and env genes possessing intrasubtype distance (<15%) to the CRF01_AE and CRF02_AG radiations. The genomic composition of this strain comprising gene segments of subtypes A and G as well as CRF01_AE and CRF02_AG defines this strain as a circulating SGR (CSGR), and the 37th CRF to be identified. Furthermore, more than half of CRF19_cpx, a CRF identified in Cuba, clusters with CRF37_cpx, and the clear genetic distance among the viruses in this cluster suggests this strain has been in circulation since the early days of the epidemic. The genetically distant segments comprising CRF37_cpx, which were found to cluster outside the crown groups of previously described viruses, may represent a link to very rare or extinct strains, and, potentially, to understanding the evolutionary history of HIV-1 in this region.</abstract><cop>Larchmont, NY</cop><pub>Liebert</pub><pmid>17678477</pmid><doi>10.1089/aid.2007.0040</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0889-2229 |
| ispartof | AIDS research and human retroviruses, 2007-07, Vol.23 (7), p.923-933 |
| issn | 0889-2229 1931-8405 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68124569 |
| source | Mary Ann Liebert Online Subscription; MEDLINE; Alma/SFX Local Collection |
| subjects | AIDS/HIV Biological and medical sciences Biological diversity Cameroon - epidemiology Distribution Evolution, Molecular Fundamental and applied biological sciences. Psychology Genetic aspects Health aspects HIV (Viruses) HIV Infections - epidemiology HIV Infections - genetics HIV-1 - classification HIV-1 - genetics Human immunodeficiency virus 1 Human viral diseases Humans Infectious diseases Medical sciences Microbiology Miscellaneous Molecular Sequence Data Phylogeny Recombination, Genetic Retrovirus Viral diseases Virology |
| title | Circulating recombinant form (CRF) 37_cpx : An old strain in cameroon composed of diverse, genetically distant lineages of subtypes A and G |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T05%3A11%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Circulating%20recombinant%20form%20(CRF)%2037_cpx%20:%20An%20old%20strain%20in%20cameroon%20composed%20of%20diverse,%20genetically%20distant%20lineages%20of%20subtypes%20A%20and%20G&rft.jtitle=AIDS%20research%20and%20human%20retroviruses&rft.au=POWELL,%20Rebecca%20L.%20R&rft.date=2007-07-01&rft.volume=23&rft.issue=7&rft.spage=923&rft.epage=933&rft.pages=923-933&rft.issn=0889-2229&rft.eissn=1931-8405&rft.coden=ARHRE7&rft_id=info:doi/10.1089/aid.2007.0040&rft_dat=%3Cgale_proqu%3EA191647080%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=20255169&rft_id=info:pmid/17678477&rft_galeid=A191647080&rfr_iscdi=true |