Effect of subcentimeter nonpositive resection margin on hepatic recurrence in patients undergoing hepatectomy for colorectal liver metastases. Evidences from 663 liver resections

Objective: To elucidate if a nonpositive

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Veröffentlicht in:Annals of oncology 2007-07, Vol.18 (7), p.1190-1195
Hauptverfasser: Figueras, J, Burdio, F, Ramos, E, Torras, J, Llado, L, Lopez-Ben, S, Codina-Barreras, A, Mojal, S
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container_end_page 1195
container_issue 7
container_start_page 1190
container_title Annals of oncology
container_volume 18
creator Figueras, J
Burdio, F
Ramos, E
Torras, J
Llado, L
Lopez-Ben, S
Codina-Barreras, A
Mojal, S
description Objective: To elucidate if a nonpositive
doi_str_mv 10.1093/annonc/mdm106
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Evidences from 663 liver resections</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Figueras, J ; Burdio, F ; Ramos, E ; Torras, J ; Llado, L ; Lopez-Ben, S ; Codina-Barreras, A ; Mojal, S</creator><creatorcontrib>Figueras, J ; Burdio, F ; Ramos, E ; Torras, J ; Llado, L ; Lopez-Ben, S ; Codina-Barreras, A ; Mojal, S</creatorcontrib><description><![CDATA[Objective: To elucidate if a nonpositive <1-cm resection margin has any effect on hepatic recurrence in patients undergoing liver resection for colorectal liver metastases. Patients and methods: Six hundred and nine patients underwent 663 liver resections. Patients with positive margin were excluded from the analysis. Two groups were studied: group A, <1-cm resection margin and group B, ≥1-cm resection margin. Results: A total of 545 liver resections in 523 patients were carried out with nonpositive resection margins. With a median follow-up of 25 months, the 5-year cumulative hepatic recurrence reached 54% in group A (n = 206) and 41% in group B (n = 339). Factors associated with hepatic recurrence were synchronic metastases (P = 0.0015), bilobar (P < 0.001), two or more metastases (P < 0.001), margin <1 cm (P = 0.0123) and extrahepatic disease (P = 0.0037). A strong correlation between resection margin and number of metastases was confirmed (P < 0.001). At multivariate analysis only two factors were independent predictors of hepatic recurrence: multinodular disease in the liver specimen [≥4 metastases hazard ratio (HR) = 3.45; 95% confidence interval (CI): 2.2–5.38; P < 0.001] and extrahepatic disease at hepatectomy (HR = 1.58; 95% CI: 1.58–3.32). Conclusion: Subcentimeter nonpositive resection margins do not directly influence hepatic recurrence in patients undergoing hepatectomy for colorectal liver metastases.]]></description><identifier>ISSN: 0923-7534</identifier><identifier>EISSN: 1569-8041</identifier><identifier>DOI: 10.1093/annonc/mdm106</identifier><identifier>PMID: 17434896</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adenocarcinoma - secondary ; Adenocarcinoma - surgery ; Aged ; Antineoplastic agents ; Biological and medical sciences ; colorectal cancer ; Colorectal Neoplasms - pathology ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; hepatectomy ; Hepatectomy - methods ; Humans ; liver metastases ; liver neoplasms ; Liver Neoplasms - secondary ; Liver Neoplasms - surgery ; liver surgery ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Middle Aged ; Neoplasm Recurrence, Local - pathology ; Pharmacology. Drug treatments ; Prognosis ; resection margin ; Retrospective Studies ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors</subject><ispartof>Annals of oncology, 2007-07, Vol.18 (7), p.1190-1195</ispartof><rights>2007 European Society for Medical Oncology 2007</rights><rights>2007 INIST-CNRS</rights><rights>2007 European Society for Medical Oncology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c524t-cc6c7e55304b9385962fb5485cbf045c2d6f44b5f854dcf1b65fc243f803e2623</citedby><cites>FETCH-LOGICAL-c524t-cc6c7e55304b9385962fb5485cbf045c2d6f44b5f854dcf1b65fc243f803e2623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=19013728$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17434896$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Figueras, J</creatorcontrib><creatorcontrib>Burdio, F</creatorcontrib><creatorcontrib>Ramos, E</creatorcontrib><creatorcontrib>Torras, J</creatorcontrib><creatorcontrib>Llado, L</creatorcontrib><creatorcontrib>Lopez-Ben, S</creatorcontrib><creatorcontrib>Codina-Barreras, A</creatorcontrib><creatorcontrib>Mojal, S</creatorcontrib><title>Effect of subcentimeter nonpositive resection margin on hepatic recurrence in patients undergoing hepatectomy for colorectal liver metastases. Evidences from 663 liver resections</title><title>Annals of oncology</title><addtitle>Ann Oncol</addtitle><description><![CDATA[Objective: To elucidate if a nonpositive <1-cm resection margin has any effect on hepatic recurrence in patients undergoing liver resection for colorectal liver metastases. Patients and methods: Six hundred and nine patients underwent 663 liver resections. Patients with positive margin were excluded from the analysis. Two groups were studied: group A, <1-cm resection margin and group B, ≥1-cm resection margin. Results: A total of 545 liver resections in 523 patients were carried out with nonpositive resection margins. With a median follow-up of 25 months, the 5-year cumulative hepatic recurrence reached 54% in group A (n = 206) and 41% in group B (n = 339). Factors associated with hepatic recurrence were synchronic metastases (P = 0.0015), bilobar (P < 0.001), two or more metastases (P < 0.001), margin <1 cm (P = 0.0123) and extrahepatic disease (P = 0.0037). A strong correlation between resection margin and number of metastases was confirmed (P < 0.001). At multivariate analysis only two factors were independent predictors of hepatic recurrence: multinodular disease in the liver specimen [≥4 metastases hazard ratio (HR) = 3.45; 95% confidence interval (CI): 2.2–5.38; P < 0.001] and extrahepatic disease at hepatectomy (HR = 1.58; 95% CI: 1.58–3.32). Conclusion: Subcentimeter nonpositive resection margins do not directly influence hepatic recurrence in patients undergoing hepatectomy for colorectal liver metastases.]]></description><subject>Adenocarcinoma - secondary</subject><subject>Adenocarcinoma - surgery</subject><subject>Aged</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>colorectal cancer</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>hepatectomy</subject><subject>Hepatectomy - methods</subject><subject>Humans</subject><subject>liver metastases</subject><subject>liver neoplasms</subject><subject>Liver Neoplasms - secondary</subject><subject>Liver Neoplasms - surgery</subject><subject>liver surgery</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Pharmacology. Drug treatments</subject><subject>Prognosis</subject><subject>resection margin</subject><subject>Retrospective Studies</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Tumors</subject><issn>0923-7534</issn><issn>1569-8041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0V1r1TAYB_AiijtOL72VICjedMt7m0sZxx1hoKCCeBPSNDlmtslZ0g73tfyEPoeWDbwRAgnNL_88zVNVLwk-I1ixcxNjivZ87EeC5aNqQ4RUdYs5eVxtsKKsbgTjJ9WzUq4xxlJR9bQ6IQ1nvFVyU_3Zeu_shJJHZe6si1MY3eQygtRDKmEKtw5lV8CEFNFo8j5EBKuf7mCmYGHPzjm7aB2CjeM3yChojr3L-xTifpFwPo13yKeMbBoSnJrMgAZIzwguNAWGK2doexv6Y1hBPqcRSclWdF9DeV498WYo7sU6n1bfPmy_Xuzqq0-XHy_eX9VWUD7V1krbOCEY5p1irVCS-k7wVtjOYy4s7aXnvBO-Fby3nnRSeEs58y1mjkrKTqu3S-4hp5vZlUmPoVg3DCa6NBctWwK8YQBf_wOv05wj1KaJgj9QtCGA6gXZnErJzutDDvCcd5pgfeykXjqpl06Cf7WGzt3o-ge9tg7AmxWYYs3gs4k2lAenMGENbcG9W1yaD_-9c60xlMn9vscm_9KyYY3Qu-8_NGGXX3b0M9E79hfq68n2</recordid><startdate>20070701</startdate><enddate>20070701</enddate><creator>Figueras, J</creator><creator>Burdio, F</creator><creator>Ramos, E</creator><creator>Torras, J</creator><creator>Llado, L</creator><creator>Lopez-Ben, S</creator><creator>Codina-Barreras, A</creator><creator>Mojal, S</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20070701</creationdate><title>Effect of subcentimeter nonpositive resection margin on hepatic recurrence in patients undergoing hepatectomy for colorectal liver metastases. Evidences from 663 liver resections</title><author>Figueras, J ; Burdio, F ; Ramos, E ; Torras, J ; Llado, L ; Lopez-Ben, S ; Codina-Barreras, A ; Mojal, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c524t-cc6c7e55304b9385962fb5485cbf045c2d6f44b5f854dcf1b65fc243f803e2623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adenocarcinoma - secondary</topic><topic>Adenocarcinoma - surgery</topic><topic>Aged</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>colorectal cancer</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>hepatectomy</topic><topic>Hepatectomy - methods</topic><topic>Humans</topic><topic>liver metastases</topic><topic>liver neoplasms</topic><topic>Liver Neoplasms - secondary</topic><topic>Liver Neoplasms - surgery</topic><topic>liver surgery</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Pharmacology. Drug treatments</topic><topic>Prognosis</topic><topic>resection margin</topic><topic>Retrospective Studies</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Figueras, J</creatorcontrib><creatorcontrib>Burdio, F</creatorcontrib><creatorcontrib>Ramos, E</creatorcontrib><creatorcontrib>Torras, J</creatorcontrib><creatorcontrib>Llado, L</creatorcontrib><creatorcontrib>Lopez-Ben, S</creatorcontrib><creatorcontrib>Codina-Barreras, A</creatorcontrib><creatorcontrib>Mojal, S</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Figueras, J</au><au>Burdio, F</au><au>Ramos, E</au><au>Torras, J</au><au>Llado, L</au><au>Lopez-Ben, S</au><au>Codina-Barreras, A</au><au>Mojal, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of subcentimeter nonpositive resection margin on hepatic recurrence in patients undergoing hepatectomy for colorectal liver metastases. Evidences from 663 liver resections</atitle><jtitle>Annals of oncology</jtitle><addtitle>Ann Oncol</addtitle><date>2007-07-01</date><risdate>2007</risdate><volume>18</volume><issue>7</issue><spage>1190</spage><epage>1195</epage><pages>1190-1195</pages><issn>0923-7534</issn><eissn>1569-8041</eissn><abstract><![CDATA[Objective: To elucidate if a nonpositive <1-cm resection margin has any effect on hepatic recurrence in patients undergoing liver resection for colorectal liver metastases. Patients and methods: Six hundred and nine patients underwent 663 liver resections. Patients with positive margin were excluded from the analysis. Two groups were studied: group A, <1-cm resection margin and group B, ≥1-cm resection margin. Results: A total of 545 liver resections in 523 patients were carried out with nonpositive resection margins. With a median follow-up of 25 months, the 5-year cumulative hepatic recurrence reached 54% in group A (n = 206) and 41% in group B (n = 339). Factors associated with hepatic recurrence were synchronic metastases (P = 0.0015), bilobar (P < 0.001), two or more metastases (P < 0.001), margin <1 cm (P = 0.0123) and extrahepatic disease (P = 0.0037). A strong correlation between resection margin and number of metastases was confirmed (P < 0.001). At multivariate analysis only two factors were independent predictors of hepatic recurrence: multinodular disease in the liver specimen [≥4 metastases hazard ratio (HR) = 3.45; 95% confidence interval (CI): 2.2–5.38; P < 0.001] and extrahepatic disease at hepatectomy (HR = 1.58; 95% CI: 1.58–3.32). Conclusion: Subcentimeter nonpositive resection margins do not directly influence hepatic recurrence in patients undergoing hepatectomy for colorectal liver metastases.]]></abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>17434896</pmid><doi>10.1093/annonc/mdm106</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
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subjects Adenocarcinoma - secondary
Adenocarcinoma - surgery
Aged
Antineoplastic agents
Biological and medical sciences
colorectal cancer
Colorectal Neoplasms - pathology
Female
Gastroenterology. Liver. Pancreas. Abdomen
hepatectomy
Hepatectomy - methods
Humans
liver metastases
liver neoplasms
Liver Neoplasms - secondary
Liver Neoplasms - surgery
liver surgery
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Middle Aged
Neoplasm Recurrence, Local - pathology
Pharmacology. Drug treatments
Prognosis
resection margin
Retrospective Studies
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
title Effect of subcentimeter nonpositive resection margin on hepatic recurrence in patients undergoing hepatectomy for colorectal liver metastases. Evidences from 663 liver resections
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