Effect of subcentimeter nonpositive resection margin on hepatic recurrence in patients undergoing hepatectomy for colorectal liver metastases. Evidences from 663 liver resections
Objective: To elucidate if a nonpositive
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Veröffentlicht in: | Annals of oncology 2007-07, Vol.18 (7), p.1190-1195 |
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container_title | Annals of oncology |
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creator | Figueras, J Burdio, F Ramos, E Torras, J Llado, L Lopez-Ben, S Codina-Barreras, A Mojal, S |
description | Objective: To elucidate if a nonpositive |
doi_str_mv | 10.1093/annonc/mdm106 |
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Evidences from 663 liver resections</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Figueras, J ; Burdio, F ; Ramos, E ; Torras, J ; Llado, L ; Lopez-Ben, S ; Codina-Barreras, A ; Mojal, S</creator><creatorcontrib>Figueras, J ; Burdio, F ; Ramos, E ; Torras, J ; Llado, L ; Lopez-Ben, S ; Codina-Barreras, A ; Mojal, S</creatorcontrib><description><![CDATA[Objective: To elucidate if a nonpositive <1-cm resection margin has any effect on hepatic recurrence in patients undergoing liver resection for colorectal liver metastases. Patients and methods: Six hundred and nine patients underwent 663 liver resections. Patients with positive margin were excluded from the analysis. Two groups were studied: group A, <1-cm resection margin and group B, ≥1-cm resection margin. Results: A total of 545 liver resections in 523 patients were carried out with nonpositive resection margins. With a median follow-up of 25 months, the 5-year cumulative hepatic recurrence reached 54% in group A (n = 206) and 41% in group B (n = 339). Factors associated with hepatic recurrence were synchronic metastases (P = 0.0015), bilobar (P < 0.001), two or more metastases (P < 0.001), margin <1 cm (P = 0.0123) and extrahepatic disease (P = 0.0037). A strong correlation between resection margin and number of metastases was confirmed (P < 0.001). At multivariate analysis only two factors were independent predictors of hepatic recurrence: multinodular disease in the liver specimen [≥4 metastases hazard ratio (HR) = 3.45; 95% confidence interval (CI): 2.2–5.38; P < 0.001] and extrahepatic disease at hepatectomy (HR = 1.58; 95% CI: 1.58–3.32). Conclusion: Subcentimeter nonpositive resection margins do not directly influence hepatic recurrence in patients undergoing hepatectomy for colorectal liver metastases.]]></description><identifier>ISSN: 0923-7534</identifier><identifier>EISSN: 1569-8041</identifier><identifier>DOI: 10.1093/annonc/mdm106</identifier><identifier>PMID: 17434896</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adenocarcinoma - secondary ; Adenocarcinoma - surgery ; Aged ; Antineoplastic agents ; Biological and medical sciences ; colorectal cancer ; Colorectal Neoplasms - pathology ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; hepatectomy ; Hepatectomy - methods ; Humans ; liver metastases ; liver neoplasms ; Liver Neoplasms - secondary ; Liver Neoplasms - surgery ; liver surgery ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Middle Aged ; Neoplasm Recurrence, Local - pathology ; Pharmacology. Drug treatments ; Prognosis ; resection margin ; Retrospective Studies ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors</subject><ispartof>Annals of oncology, 2007-07, Vol.18 (7), p.1190-1195</ispartof><rights>2007 European Society for Medical Oncology 2007</rights><rights>2007 INIST-CNRS</rights><rights>2007 European Society for Medical Oncology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c524t-cc6c7e55304b9385962fb5485cbf045c2d6f44b5f854dcf1b65fc243f803e2623</citedby><cites>FETCH-LOGICAL-c524t-cc6c7e55304b9385962fb5485cbf045c2d6f44b5f854dcf1b65fc243f803e2623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19013728$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17434896$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Figueras, J</creatorcontrib><creatorcontrib>Burdio, F</creatorcontrib><creatorcontrib>Ramos, E</creatorcontrib><creatorcontrib>Torras, J</creatorcontrib><creatorcontrib>Llado, L</creatorcontrib><creatorcontrib>Lopez-Ben, S</creatorcontrib><creatorcontrib>Codina-Barreras, A</creatorcontrib><creatorcontrib>Mojal, S</creatorcontrib><title>Effect of subcentimeter nonpositive resection margin on hepatic recurrence in patients undergoing hepatectomy for colorectal liver metastases. Evidences from 663 liver resections</title><title>Annals of oncology</title><addtitle>Ann Oncol</addtitle><description><![CDATA[Objective: To elucidate if a nonpositive <1-cm resection margin has any effect on hepatic recurrence in patients undergoing liver resection for colorectal liver metastases. Patients and methods: Six hundred and nine patients underwent 663 liver resections. Patients with positive margin were excluded from the analysis. Two groups were studied: group A, <1-cm resection margin and group B, ≥1-cm resection margin. Results: A total of 545 liver resections in 523 patients were carried out with nonpositive resection margins. With a median follow-up of 25 months, the 5-year cumulative hepatic recurrence reached 54% in group A (n = 206) and 41% in group B (n = 339). Factors associated with hepatic recurrence were synchronic metastases (P = 0.0015), bilobar (P < 0.001), two or more metastases (P < 0.001), margin <1 cm (P = 0.0123) and extrahepatic disease (P = 0.0037). A strong correlation between resection margin and number of metastases was confirmed (P < 0.001). At multivariate analysis only two factors were independent predictors of hepatic recurrence: multinodular disease in the liver specimen [≥4 metastases hazard ratio (HR) = 3.45; 95% confidence interval (CI): 2.2–5.38; P < 0.001] and extrahepatic disease at hepatectomy (HR = 1.58; 95% CI: 1.58–3.32). Conclusion: Subcentimeter nonpositive resection margins do not directly influence hepatic recurrence in patients undergoing hepatectomy for colorectal liver metastases.]]></description><subject>Adenocarcinoma - secondary</subject><subject>Adenocarcinoma - surgery</subject><subject>Aged</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>colorectal cancer</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>hepatectomy</subject><subject>Hepatectomy - methods</subject><subject>Humans</subject><subject>liver metastases</subject><subject>liver neoplasms</subject><subject>Liver Neoplasms - secondary</subject><subject>Liver Neoplasms - surgery</subject><subject>liver surgery</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Pharmacology. Drug treatments</subject><subject>Prognosis</subject><subject>resection margin</subject><subject>Retrospective Studies</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Tumors</subject><issn>0923-7534</issn><issn>1569-8041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0V1r1TAYB_AiijtOL72VICjedMt7m0sZxx1hoKCCeBPSNDlmtslZ0g73tfyEPoeWDbwRAgnNL_88zVNVLwk-I1ixcxNjivZ87EeC5aNqQ4RUdYs5eVxtsKKsbgTjJ9WzUq4xxlJR9bQ6IQ1nvFVyU_3Zeu_shJJHZe6si1MY3eQygtRDKmEKtw5lV8CEFNFo8j5EBKuf7mCmYGHPzjm7aB2CjeM3yChojr3L-xTifpFwPo13yKeMbBoSnJrMgAZIzwguNAWGK2doexv6Y1hBPqcRSclWdF9DeV498WYo7sU6n1bfPmy_Xuzqq0-XHy_eX9VWUD7V1krbOCEY5p1irVCS-k7wVtjOYy4s7aXnvBO-Fby3nnRSeEs58y1mjkrKTqu3S-4hp5vZlUmPoVg3DCa6NBctWwK8YQBf_wOv05wj1KaJgj9QtCGA6gXZnErJzutDDvCcd5pgfeykXjqpl06Cf7WGzt3o-ge9tg7AmxWYYs3gs4k2lAenMGENbcG9W1yaD_-9c60xlMn9vscm_9KyYY3Qu-8_NGGXX3b0M9E79hfq68n2</recordid><startdate>20070701</startdate><enddate>20070701</enddate><creator>Figueras, J</creator><creator>Burdio, F</creator><creator>Ramos, E</creator><creator>Torras, J</creator><creator>Llado, L</creator><creator>Lopez-Ben, S</creator><creator>Codina-Barreras, A</creator><creator>Mojal, S</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20070701</creationdate><title>Effect of subcentimeter nonpositive resection margin on hepatic recurrence in patients undergoing hepatectomy for colorectal liver metastases. Evidences from 663 liver resections</title><author>Figueras, J ; Burdio, F ; Ramos, E ; Torras, J ; Llado, L ; Lopez-Ben, S ; Codina-Barreras, A ; Mojal, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c524t-cc6c7e55304b9385962fb5485cbf045c2d6f44b5f854dcf1b65fc243f803e2623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adenocarcinoma - secondary</topic><topic>Adenocarcinoma - surgery</topic><topic>Aged</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>colorectal cancer</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>hepatectomy</topic><topic>Hepatectomy - methods</topic><topic>Humans</topic><topic>liver metastases</topic><topic>liver neoplasms</topic><topic>Liver Neoplasms - secondary</topic><topic>Liver Neoplasms - surgery</topic><topic>liver surgery</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Pharmacology. Drug treatments</topic><topic>Prognosis</topic><topic>resection margin</topic><topic>Retrospective Studies</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Figueras, J</creatorcontrib><creatorcontrib>Burdio, F</creatorcontrib><creatorcontrib>Ramos, E</creatorcontrib><creatorcontrib>Torras, J</creatorcontrib><creatorcontrib>Llado, L</creatorcontrib><creatorcontrib>Lopez-Ben, S</creatorcontrib><creatorcontrib>Codina-Barreras, A</creatorcontrib><creatorcontrib>Mojal, S</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Figueras, J</au><au>Burdio, F</au><au>Ramos, E</au><au>Torras, J</au><au>Llado, L</au><au>Lopez-Ben, S</au><au>Codina-Barreras, A</au><au>Mojal, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of subcentimeter nonpositive resection margin on hepatic recurrence in patients undergoing hepatectomy for colorectal liver metastases. Evidences from 663 liver resections</atitle><jtitle>Annals of oncology</jtitle><addtitle>Ann Oncol</addtitle><date>2007-07-01</date><risdate>2007</risdate><volume>18</volume><issue>7</issue><spage>1190</spage><epage>1195</epage><pages>1190-1195</pages><issn>0923-7534</issn><eissn>1569-8041</eissn><abstract><![CDATA[Objective: To elucidate if a nonpositive <1-cm resection margin has any effect on hepatic recurrence in patients undergoing liver resection for colorectal liver metastases. Patients and methods: Six hundred and nine patients underwent 663 liver resections. Patients with positive margin were excluded from the analysis. Two groups were studied: group A, <1-cm resection margin and group B, ≥1-cm resection margin. Results: A total of 545 liver resections in 523 patients were carried out with nonpositive resection margins. With a median follow-up of 25 months, the 5-year cumulative hepatic recurrence reached 54% in group A (n = 206) and 41% in group B (n = 339). Factors associated with hepatic recurrence were synchronic metastases (P = 0.0015), bilobar (P < 0.001), two or more metastases (P < 0.001), margin <1 cm (P = 0.0123) and extrahepatic disease (P = 0.0037). A strong correlation between resection margin and number of metastases was confirmed (P < 0.001). At multivariate analysis only two factors were independent predictors of hepatic recurrence: multinodular disease in the liver specimen [≥4 metastases hazard ratio (HR) = 3.45; 95% confidence interval (CI): 2.2–5.38; P < 0.001] and extrahepatic disease at hepatectomy (HR = 1.58; 95% CI: 1.58–3.32). Conclusion: Subcentimeter nonpositive resection margins do not directly influence hepatic recurrence in patients undergoing hepatectomy for colorectal liver metastases.]]></abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>17434896</pmid><doi>10.1093/annonc/mdm106</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adenocarcinoma - secondary Adenocarcinoma - surgery Aged Antineoplastic agents Biological and medical sciences colorectal cancer Colorectal Neoplasms - pathology Female Gastroenterology. Liver. Pancreas. Abdomen hepatectomy Hepatectomy - methods Humans liver metastases liver neoplasms Liver Neoplasms - secondary Liver Neoplasms - surgery liver surgery Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Neoplasm Recurrence, Local - pathology Pharmacology. Drug treatments Prognosis resection margin Retrospective Studies Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
title | Effect of subcentimeter nonpositive resection margin on hepatic recurrence in patients undergoing hepatectomy for colorectal liver metastases. Evidences from 663 liver resections |
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