DNA Condensation and Cell Transfection Properties of Guanidinium Calixarenes:  Dependence on Macrocycle Lipophilicity, Size, and Conformation

Calix[n]arenes functionalized with guanidinium groups at the upper rim and alkyl chains at the lower rim bind to DNA, condense it, and in some cases, promote cell transfection depending on their structure and lipophilicity. Atomic force microscopy (AFM) studies indicate that upon DNA binding the hyd...

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