Fc glycans terminated with N-acetylglucosamine residues increase antibody resistance to papain

Glycosylation in the CH2 domain of Fc is required for immunoglobulins G (IgGs) to exhibit immune effector functions including complement-dependent cytotoxicity (CDC) and antibody-dependent (Ab-dependent) cellular cytotoxicity (ADCC). We recently established that glycosylated Abs are more resistant t...

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Veröffentlicht in:	Biotechnology progress 2007-07, Vol.23 (4), p.964-971
Hauptverfasser:	RAJU, T. Shantha, SCALLON, Bernard
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylglucosamine - chemistry Animals Biological and medical sciences Biotechnology Carbohydrates - chemistry Chromatography - methods Chromatography, High Pressure Liquid Fundamental and applied biological sciences. Psychology Glycosylation Humans Immunoglobulin G - chemistry Mice Models, Chemical Oligosaccharides - chemistry Papain - chemistry Polysaccharides - chemistry Protein Engineering Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Online-Zugang:	Volltext
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