Lectin-modified solid lipid nanoparticles as carriers for oral administration of insulin

The aim of this study was to design and characterize lectin-modified solid lipid nanoparticles (SLNs) containing insulin and to evaluate the potential of the lectin-modified colloidal carriers for oral administration of peptide and protein drugs. SLNs were prepared by three different methods. For co...

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Veröffentlicht in:	International journal of pharmaceutics 2006-12, Vol.327 (1), p.153-159
Hauptverfasser:	Zhang, Na, Ping, Qineng, Huang, Guihua, Xu, Wenfang, Cheng, Yanna, Han, Xiuzhen
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Biological Availability Blood Glucose - analysis Chemistry, Pharmaceutical Drug Carriers Drug Stability Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - chemistry Hypoglycemic Agents - pharmacokinetics Insulin Insulin - administration & dosage Insulin - chemistry Insulin - pharmacokinetics Intestinal Absorption - drug effects Nanoparticles - administration & dosage Nanoparticles - chemistry Oral administration Phosphatidylethanolamines - administration & dosage Phosphatidylethanolamines - chemistry Rats Rats, Sprague-Dawley Solid lipid nanoparticles Triticum aestivum Wheat germ agglutinin Wheat Germ Agglutinins - administration & dosage Wheat Germ Agglutinins - chemistry
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