Apoptosis in alpha interferon (IFN-alpha) intratumoral chemotherapy for cystic craniopharyngiomas
The aim of this study was to verify whether intracystic injections of alpha-Interferon (IFN-alpha) in cystic craniopharyngiomas were able to reduce the tumor by activating the Fas apoptotic pathway. Twenty-one patients with cystic craniopharyngiomas treated at the Pediatric Oncology Institute (IOP/G...
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| Veröffentlicht in: | Child's nervous system 2007-09, Vol.23 (9), p.1041-1046 |
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| container_title | Child's nervous system |
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| creator | Ierardi, D F Fernandes, M J S Silva, I R Thomazini-Gouveia, J Silva, N S Dastoli, P Toledo, S R C Cavalheiro, S |
| description | The aim of this study was to verify whether intracystic injections of alpha-Interferon (IFN-alpha) in cystic craniopharyngiomas were able to reduce the tumor by activating the Fas apoptotic pathway.
Twenty-one patients with cystic craniopharyngiomas treated at the Pediatric Oncology Institute (IOP/GRAACC) of Federal University of São Paulo were submitted to intracystic chemotherapy with IFN-alpha. The tumor sizes of all patients were monitored and the apoptotic factor soluble FasL (sFasL) concentration was determined by ELISA (enzyme-linked immunosorbent assay) in tumor fluid samples from eight patients.
There was a complete reduction in 11 patients, a partial response in seven, and a minor response in three patients. The concentration of sFasL was increased in all the eight patients examined concomitantly with the tumor size reduction.
Our data demonstrated that the IFN-alpha was able to induce Fas-mediated apoptosis together with a reduction in the tumor size; such an observation may suggest the importance to investigate still unexplored mechanisms to be exploited in craniopharyngioma therapy. |
| doi_str_mv | 10.1007/s00381-007-0409-3 |
| format | Article |
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Twenty-one patients with cystic craniopharyngiomas treated at the Pediatric Oncology Institute (IOP/GRAACC) of Federal University of São Paulo were submitted to intracystic chemotherapy with IFN-alpha. The tumor sizes of all patients were monitored and the apoptotic factor soluble FasL (sFasL) concentration was determined by ELISA (enzyme-linked immunosorbent assay) in tumor fluid samples from eight patients.
There was a complete reduction in 11 patients, a partial response in seven, and a minor response in three patients. The concentration of sFasL was increased in all the eight patients examined concomitantly with the tumor size reduction.
Our data demonstrated that the IFN-alpha was able to induce Fas-mediated apoptosis together with a reduction in the tumor size; such an observation may suggest the importance to investigate still unexplored mechanisms to be exploited in craniopharyngioma therapy.</description><identifier>ISSN: 0256-7040</identifier><identifier>EISSN: 1433-0350</identifier><identifier>DOI: 10.1007/s00381-007-0409-3</identifier><identifier>PMID: 17593372</identifier><language>eng</language><publisher>Germany</publisher><subject>Adolescent ; Adult ; Apoptosis - drug effects ; Child ; Child, Preschool ; Craniopharyngioma - pathology ; Craniopharyngioma - therapy ; Drug Therapy - methods ; Enzyme-Linked Immunosorbent Assay - methods ; Fas Ligand Protein - metabolism ; Female ; Humans ; Immunologic Factors - therapeutic use ; Infant ; Interferon-alpha - therapeutic use ; Magnetic Resonance Imaging - methods ; Male ; Pituitary Neoplasms - pathology ; Pituitary Neoplasms - therapy ; Retrospective Studies ; Tomography Scanners, X-Ray Computed</subject><ispartof>Child's nervous system, 2007-09, Vol.23 (9), p.1041-1046</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c299t-32267a4ac0e4248536e7676856a0e9de774b3c8f32444a6aa56ec40ad02aa0363</citedby><cites>FETCH-LOGICAL-c299t-32267a4ac0e4248536e7676856a0e9de774b3c8f32444a6aa56ec40ad02aa0363</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17593372$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ierardi, D F</creatorcontrib><creatorcontrib>Fernandes, M J S</creatorcontrib><creatorcontrib>Silva, I R</creatorcontrib><creatorcontrib>Thomazini-Gouveia, J</creatorcontrib><creatorcontrib>Silva, N S</creatorcontrib><creatorcontrib>Dastoli, P</creatorcontrib><creatorcontrib>Toledo, S R C</creatorcontrib><creatorcontrib>Cavalheiro, S</creatorcontrib><title>Apoptosis in alpha interferon (IFN-alpha) intratumoral chemotherapy for cystic craniopharyngiomas</title><title>Child's nervous system</title><addtitle>Childs Nerv Syst</addtitle><description>The aim of this study was to verify whether intracystic injections of alpha-Interferon (IFN-alpha) in cystic craniopharyngiomas were able to reduce the tumor by activating the Fas apoptotic pathway.
Twenty-one patients with cystic craniopharyngiomas treated at the Pediatric Oncology Institute (IOP/GRAACC) of Federal University of São Paulo were submitted to intracystic chemotherapy with IFN-alpha. The tumor sizes of all patients were monitored and the apoptotic factor soluble FasL (sFasL) concentration was determined by ELISA (enzyme-linked immunosorbent assay) in tumor fluid samples from eight patients.
There was a complete reduction in 11 patients, a partial response in seven, and a minor response in three patients. The concentration of sFasL was increased in all the eight patients examined concomitantly with the tumor size reduction.
Our data demonstrated that the IFN-alpha was able to induce Fas-mediated apoptosis together with a reduction in the tumor size; such an observation may suggest the importance to investigate still unexplored mechanisms to be exploited in craniopharyngioma therapy.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Apoptosis - drug effects</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Craniopharyngioma - pathology</subject><subject>Craniopharyngioma - therapy</subject><subject>Drug Therapy - methods</subject><subject>Enzyme-Linked Immunosorbent Assay - methods</subject><subject>Fas Ligand Protein - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Immunologic Factors - therapeutic use</subject><subject>Infant</subject><subject>Interferon-alpha - therapeutic use</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Pituitary Neoplasms - pathology</subject><subject>Pituitary Neoplasms - therapy</subject><subject>Retrospective Studies</subject><subject>Tomography Scanners, X-Ray Computed</subject><issn>0256-7040</issn><issn>1433-0350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1OwzAQhC0EoqXwAFxQTggOhrXXsZNjVfFTqYILnKOt69CgJA52eujbk9BKnHa0OzNafYxdC3gQAOYxAmAm-CA5KMg5nrCpUIgcMIVTNgWZam6G04RdxPgNINJM5udsIkyaIxo5ZTTvfNf7WMWkahOquy0NonehdMG3yd3y-Y3_be_HdaB-1_hAdWK3rvH91gXq9knpQ2L3sa9sYgO1lR_8Yd9-Vb6heMnOSqqjuzrOGft8fvpYvPLV-8tyMV9xK_O85yilNqTIglNSZSlqZ7TRWaoJXL5xxqg12qxEqZQiTZRqZxXQBiQRoMYZuz30dsH_7Fzsi6aK1tU1tc7vYqEzISVKHIziYLTBxxhcWXShaoaHCwHFyLU4cC1GOXItxszNsXy3btzmP3EEib9CwXQT</recordid><startdate>20070901</startdate><enddate>20070901</enddate><creator>Ierardi, D F</creator><creator>Fernandes, M J S</creator><creator>Silva, I R</creator><creator>Thomazini-Gouveia, J</creator><creator>Silva, N S</creator><creator>Dastoli, P</creator><creator>Toledo, S R C</creator><creator>Cavalheiro, S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070901</creationdate><title>Apoptosis in alpha interferon (IFN-alpha) intratumoral chemotherapy for cystic craniopharyngiomas</title><author>Ierardi, D F ; Fernandes, M J S ; Silva, I R ; Thomazini-Gouveia, J ; Silva, N S ; Dastoli, P ; Toledo, S R C ; Cavalheiro, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c299t-32267a4ac0e4248536e7676856a0e9de774b3c8f32444a6aa56ec40ad02aa0363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Apoptosis - drug effects</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Craniopharyngioma - pathology</topic><topic>Craniopharyngioma - therapy</topic><topic>Drug Therapy - methods</topic><topic>Enzyme-Linked Immunosorbent Assay - methods</topic><topic>Fas Ligand Protein - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Immunologic Factors - therapeutic use</topic><topic>Infant</topic><topic>Interferon-alpha - therapeutic use</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Pituitary Neoplasms - pathology</topic><topic>Pituitary Neoplasms - therapy</topic><topic>Retrospective Studies</topic><topic>Tomography Scanners, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ierardi, D F</creatorcontrib><creatorcontrib>Fernandes, M J S</creatorcontrib><creatorcontrib>Silva, I R</creatorcontrib><creatorcontrib>Thomazini-Gouveia, J</creatorcontrib><creatorcontrib>Silva, N S</creatorcontrib><creatorcontrib>Dastoli, P</creatorcontrib><creatorcontrib>Toledo, S R C</creatorcontrib><creatorcontrib>Cavalheiro, S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Child's nervous system</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ierardi, D F</au><au>Fernandes, M J S</au><au>Silva, I R</au><au>Thomazini-Gouveia, J</au><au>Silva, N S</au><au>Dastoli, P</au><au>Toledo, S R C</au><au>Cavalheiro, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Apoptosis in alpha interferon (IFN-alpha) intratumoral chemotherapy for cystic craniopharyngiomas</atitle><jtitle>Child's nervous system</jtitle><addtitle>Childs Nerv Syst</addtitle><date>2007-09-01</date><risdate>2007</risdate><volume>23</volume><issue>9</issue><spage>1041</spage><epage>1046</epage><pages>1041-1046</pages><issn>0256-7040</issn><eissn>1433-0350</eissn><abstract>The aim of this study was to verify whether intracystic injections of alpha-Interferon (IFN-alpha) in cystic craniopharyngiomas were able to reduce the tumor by activating the Fas apoptotic pathway.
Twenty-one patients with cystic craniopharyngiomas treated at the Pediatric Oncology Institute (IOP/GRAACC) of Federal University of São Paulo were submitted to intracystic chemotherapy with IFN-alpha. The tumor sizes of all patients were monitored and the apoptotic factor soluble FasL (sFasL) concentration was determined by ELISA (enzyme-linked immunosorbent assay) in tumor fluid samples from eight patients.
There was a complete reduction in 11 patients, a partial response in seven, and a minor response in three patients. The concentration of sFasL was increased in all the eight patients examined concomitantly with the tumor size reduction.
Our data demonstrated that the IFN-alpha was able to induce Fas-mediated apoptosis together with a reduction in the tumor size; such an observation may suggest the importance to investigate still unexplored mechanisms to be exploited in craniopharyngioma therapy.</abstract><cop>Germany</cop><pmid>17593372</pmid><doi>10.1007/s00381-007-0409-3</doi><tpages>6</tpages></addata></record> |
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| ispartof | Child's nervous system, 2007-09, Vol.23 (9), p.1041-1046 |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Adolescent Adult Apoptosis - drug effects Child Child, Preschool Craniopharyngioma - pathology Craniopharyngioma - therapy Drug Therapy - methods Enzyme-Linked Immunosorbent Assay - methods Fas Ligand Protein - metabolism Female Humans Immunologic Factors - therapeutic use Infant Interferon-alpha - therapeutic use Magnetic Resonance Imaging - methods Male Pituitary Neoplasms - pathology Pituitary Neoplasms - therapy Retrospective Studies Tomography Scanners, X-Ray Computed |
| title | Apoptosis in alpha interferon (IFN-alpha) intratumoral chemotherapy for cystic craniopharyngiomas |
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