Regulation of Homeostatic Chemokine Expression and Cell Trafficking During Immune Responses

The chemokines CCL21 and CXCL13 are immune factors that dictate homing and motility of lymphocytes and dendritic cells in lymphoid tissues. However, the means by which these chemokines are regulated and how they influence cell trafficking during immune responses remain unclear. We show that CCL21 an...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2007-08, Vol.317 (5838), p.670-674
Hauptverfasser:	Mueller, Scott N, Hosiawa-Meagher, Karoline A, Konieczny, Bogumila T, Sullivan, Brandon M, Bachmann, Martin F, Locksley, Richard M, Ahmed, Rafi, Matloubian, Mehrdad
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Arenaviridae Infections - immunology B lymphocytes B-Lymphocytes - immunology Biological and medical sciences CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Cell Movement Cellular biology Chemokine CCL19 Chemokine CCL21 Chemokine CXCL13 Chemokines Chemokines, CC - genetics Chemokines, CC - metabolism Chemokines, CXC - genetics Chemokines, CXC - metabolism Cytokines - immunology Cytokines - metabolism Dendritic Cells - immunology Down regulation Female Fundamental and applied biological sciences. Psychology Fundamental immunology Gene expression Genetics of the immune response Homeostasis Immunization Immunobiology Immunology Infections Interferon-gamma - immunology Interferon-gamma - metabolism Listeriosis - immunology Lymph nodes Lymph Nodes - immunology Lymphocytic choriomeningitis virus Male Mice Mice, Inbred Strains Mice, Transgenic Molecular biology RNA, Messenger - genetics RNA, Messenger - metabolism Spleen Spleen - immunology T lymphocytes Virus Diseases - immunology
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