Heat Shock Treatment of Tumor Lysate-Pulsed Dendritic Cells Enhances Their Capacity to Elicit Antitumor T Cell Responses against Medullary Thyroid Carcinoma

Background: In vitro and in vivo studies have shown that dendritic cells (DCs) can stimulate antitumor T cell responses against medullary thyroid carcinoma (MTC). However, despite promising results in selected cases, the clinical efficacy of DC immunotherapy in patients with MTC has been limited. Re...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2006-11, Vol.91 (11), p.4571-4577
Hauptverfasser:	Bachleitner-Hofmann, Thomas, Strohschneider, Michaela, Krieger, Peter, Sachet, Monika, Dubsky, Peter, Hayden, Hubert, Schoppmann, Sebastian F., Pfragner, Roswitha, Gnant, Michael, Friedl, Josef, Stift, Anton
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antigens, Surface - metabolism Biological and medical sciences Carcinoma, Medullary - immunology Carcinoma, Medullary - pathology Carcinoma, Medullary - therapy Cell Differentiation Cell Extracts - immunology Dendritic Cells - metabolism Dendritic Cells - pathology Endocrinopathies Female Fundamental and applied biological sciences. Psychology Genes, MHC Class I Heat-Shock Response HLA Antigens - metabolism HSP70 Heat-Shock Proteins - metabolism HSP90 Heat-Shock Proteins - metabolism Humans Hyperthermia, Induced - methods Immunotherapy - methods In Vitro Techniques Lymphocyte Activation - immunology Male Malignant tumors Medical sciences Middle Aged T-Lymphocytes, Cytotoxic - metabolism Thyroid Neoplasms - immunology Thyroid Neoplasms - pathology Thyroid Neoplasms - therapy Thyroid. Thyroid axis (diseases) Toll-Like Receptor 2 - metabolism Toll-Like Receptor 4 - metabolism Tumor Cells, Cultured Vertebrates: endocrinology
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