cAMP-responsive element-binding protein regulates vascular endothelial growth factor expression: implication in human prostate cancer bone metastasis

Aberrant expression of vascular endothelial growth factor (VEGF) is associated with human prostate cancer (PCa) metastasis and poor clinical outcome. We found that both phosphorylation of cyclic AMP-responsive element-binding protein (CREB) and VEGF levels were significantly elevated in patient bone...

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Veröffentlicht in:	Oncogene 2007-08, Vol.26 (35), p.5070-5077
Hauptverfasser:	Wu, D, Zhau, H E, Huang, W-C, Iqbal, S, Habib, F K, Sartor, O, Cvitanovic, L, Marshall, F F, Xu, Z, Chung, L W K
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Binding proteins Biological and medical sciences Bone cancer Bone Neoplasms - genetics Bone Neoplasms - metabolism Bone Neoplasms - secondary Cell Biology Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cyclic AMP Cyclic AMP response element-binding protein Cyclic AMP Response Element-Binding Protein - analysis Cyclic AMP Response Element-Binding Protein - metabolism Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Gynecology. Andrology. Obstetrics Human Genetics Humans Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-inducible factors Internal Medicine Male Male genital diseases Medical sciences Medicine Medicine & Public Health Mesenchyme Metastases Metastasis Molecular and cellular biology Nephrology. Urinary tract diseases Oncology original-article Phosphorylation Physiological aspects Promoter Regions, Genetic Prostate cancer Prostatic Neoplasms - chemistry Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Proteins Signal transduction Transcription, Genetic Tumors Tumors of the urinary system Urinary tract. Prostate gland Vascular endothelial growth factor Vascular Endothelial Growth Factor A - blood Vascular Endothelial Growth Factor A - genetics
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