Id2 gene-targeted crosstalk between Wnt and retinoid signaling regulates proliferation in human keratinocytes

We investigated the effect of all-trans-retinoic acid (atRA) on proliferation in several human skin cell lines and found that antiproliferative potency of atRA correlated with the endogenous activity of canonical Wnt signaling. In HaCaT keratinocytes, we found that atRA significantly suppressed the...

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Veröffentlicht in:	Oncogene 2007-08, Vol.26 (35), p.5038-5045
Hauptverfasser:	MEMEZAWA, A, TAKADA, I, TAKEYAMA, K, IGARASHI, M, ITO, S, AIBA, S, KATO, S, KOUZMENKO, A. P
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Binding sites Biochemistry Biological and medical sciences c-Myc protein Cancer Cell differentiation Cell Line Cell lines Cell physiology Cell proliferation Cell Proliferation - drug effects Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cyclin D1 Cyclin D1 - metabolism Down-Regulation Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation Histone Demethylases Histone H3 Histones Histones - metabolism Humans Id2 protein Inhibitor of Differentiation Protein 2 - antagonists & inhibitors Inhibitor of Differentiation Protein 2 - genetics Keratinocytes Keratinocytes - drug effects Keratinocytes - metabolism Kinases LEF/TCF protein Methylation Molecular and cellular biology Myc protein Oncology Oxidoreductases, N-Demethylating - metabolism Physiological aspects Proto-Oncogene Proteins c-myc - metabolism Response Elements Retinoic acid Retinoids Retinoids - pharmacology Ribonucleic acid RNA RNA, Small Interfering - pharmacology Signal transduction siRNA Transcription factors Tretinoin - pharmacology Wnt protein Wnt Proteins - metabolism β-Catenin
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