CoREST-like complexes regulate chromatin modification and neuronal gene expression
The mammalian CoREST ([co]repressor for element-1-silencing transcription factor) complex was first identified associated with the repressor for element-1 silencing transcription factor (REST)/neuronal restrictive silencing factor. The CoREST complex is a chromatin-modifying corepressor complex that...
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| Veröffentlicht in: | Journal of molecular neuroscience 2006-01, Vol.29 (3), p.227-240 |
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| creator | Lakowski, Bernard Roelens, Ingele Jacob, Sandrine |
| description | The mammalian CoREST ([co]repressor for element-1-silencing transcription factor) complex was first identified associated with the repressor for element-1 silencing transcription factor (REST)/neuronal restrictive silencing factor. The CoREST complex is a chromatin-modifying corepressor complex that acts with REST to regulate neuronal gene expression and neuronal stem cell fate. Components of a CoREST-like complex have been identified recently in Xenopus laevis, Caenorhabditis elegans, and Drosophila melanogaster. Like the mammalian complex, the Drosophila complex is required to regulate neuronal gene expression, whereas the C. elegans homologs regulate the expression of the hop-1 presenilin gene, suggesting an ancient conserved function of CoREST complexes in regulating neuronal gene expression. |
| doi_str_mv | 10.1385/JMN:29:3:227 |
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The CoREST complex is a chromatin-modifying corepressor complex that acts with REST to regulate neuronal gene expression and neuronal stem cell fate. Components of a CoREST-like complex have been identified recently in Xenopus laevis, Caenorhabditis elegans, and Drosophila melanogaster. Like the mammalian complex, the Drosophila complex is required to regulate neuronal gene expression, whereas the C. elegans homologs regulate the expression of the hop-1 presenilin gene, suggesting an ancient conserved function of CoREST complexes in regulating neuronal gene expression.</description><identifier>ISSN: 0895-8696</identifier><identifier>EISSN: 0895-8696</identifier><identifier>EISSN: 1559-1166</identifier><identifier>DOI: 10.1385/JMN:29:3:227</identifier><identifier>PMID: 17085781</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Animals ; Arabidopsis Proteins - physiology ; Biological Evolution ; Caenorhabditis elegans ; Caenorhabditis elegans Proteins - physiology ; Chromatin - genetics ; Chromatin - metabolism ; Co-Repressor Proteins ; DNA-Binding Proteins - physiology ; Drosophila melanogaster ; Drosophila Proteins - physiology ; Epigenesis, Genetic ; Gene expression ; Gene Expression Regulation ; Genetics ; High Mobility Group Proteins - physiology ; Histone Deacetylase 1 ; Histone Deacetylase 2 ; Histone Deacetylases - physiology ; Histone Demethylases ; Humans ; Insects ; Invertebrates - genetics ; Invertebrates - metabolism ; Mammals - genetics ; Mammals - metabolism ; Mice ; Multiprotein Complexes - physiology ; Nerve Tissue Proteins - biosynthesis ; Nerve Tissue Proteins - genetics ; Nerve Tissue Proteins - physiology ; Neurons - metabolism ; Oxidoreductases, N-Demethylating - physiology ; Promoter Regions, Genetic ; Proteins ; Proto-Oncogene Proteins c-raf - physiology ; Repressor Proteins - physiology ; Transcription Factors - physiology ; Transcription, Genetic - physiology ; Xenopus laevis</subject><ispartof>Journal of molecular neuroscience, 2006-01, Vol.29 (3), p.227-240</ispartof><rights>Humana Press Inc. 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-c07e80be6e610721a1c0e3b6941a53efb6c3b4652cecdf88773db91b4bc969633</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17085781$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lakowski, Bernard</creatorcontrib><creatorcontrib>Roelens, Ingele</creatorcontrib><creatorcontrib>Jacob, Sandrine</creatorcontrib><title>CoREST-like complexes regulate chromatin modification and neuronal gene expression</title><title>Journal of molecular neuroscience</title><addtitle>J Mol Neurosci</addtitle><description>The mammalian CoREST ([co]repressor for element-1-silencing transcription factor) complex was first identified associated with the repressor for element-1 silencing transcription factor (REST)/neuronal restrictive silencing factor. The CoREST complex is a chromatin-modifying corepressor complex that acts with REST to regulate neuronal gene expression and neuronal stem cell fate. Components of a CoREST-like complex have been identified recently in Xenopus laevis, Caenorhabditis elegans, and Drosophila melanogaster. Like the mammalian complex, the Drosophila complex is required to regulate neuronal gene expression, whereas the C. elegans homologs regulate the expression of the hop-1 presenilin gene, suggesting an ancient conserved function of CoREST complexes in regulating neuronal gene expression.</description><subject>Animals</subject><subject>Arabidopsis Proteins - physiology</subject><subject>Biological Evolution</subject><subject>Caenorhabditis elegans</subject><subject>Caenorhabditis elegans Proteins - physiology</subject><subject>Chromatin - genetics</subject><subject>Chromatin - metabolism</subject><subject>Co-Repressor Proteins</subject><subject>DNA-Binding Proteins - physiology</subject><subject>Drosophila melanogaster</subject><subject>Drosophila Proteins - physiology</subject><subject>Epigenesis, Genetic</subject><subject>Gene expression</subject><subject>Gene Expression Regulation</subject><subject>Genetics</subject><subject>High Mobility Group Proteins - physiology</subject><subject>Histone Deacetylase 1</subject><subject>Histone Deacetylase 2</subject><subject>Histone Deacetylases - physiology</subject><subject>Histone Demethylases</subject><subject>Humans</subject><subject>Insects</subject><subject>Invertebrates - genetics</subject><subject>Invertebrates - metabolism</subject><subject>Mammals - genetics</subject><subject>Mammals - metabolism</subject><subject>Mice</subject><subject>Multiprotein Complexes - physiology</subject><subject>Nerve Tissue Proteins - biosynthesis</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Nerve Tissue Proteins - physiology</subject><subject>Neurons - metabolism</subject><subject>Oxidoreductases, N-Demethylating - physiology</subject><subject>Promoter Regions, Genetic</subject><subject>Proteins</subject><subject>Proto-Oncogene Proteins c-raf - physiology</subject><subject>Repressor Proteins - physiology</subject><subject>Transcription Factors - physiology</subject><subject>Transcription, Genetic - physiology</subject><subject>Xenopus laevis</subject><issn>0895-8696</issn><issn>0895-8696</issn><issn>1559-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkc1Lw0AQxRdRrFZvniV48GR0P5LNbm9S6hdVodbzstlMamqSjbsN1P_elRYUL57mMfPjwZuH0AnBl4SJ9Orh8WlE5YiNKM120AEWMo0Fl3z3lx6gQ--XGFOSELGPBiTDIs0EOUCzsZ1NXuZxXb1DZGzT1bAGHzlY9LVehdWbs41eVW3U2KIqKxO0bSPdFlELvbOtrqMFtBDBunPgfTgeob1S1x6Ot3OIXm8m8_FdPH2-vR9fT2PDJF7FBmcgcA4cOMEZJZoYDCznMiE6ZVDm3LA84Sk1YIpSiCxjRS5JnuRGhkiMDdH5xrdz9qMHv1JN5Q3UtW7B9l5xQShO2P8gkeEZTMoAnv0Bl7Z3IaJXQhCeykzwAF1sIOOs9w5K1bmq0e5TEay-G1GhEUWlYio0EvDTrWefN1D8wNsK2BeRrYaO</recordid><startdate>20060101</startdate><enddate>20060101</enddate><creator>Lakowski, Bernard</creator><creator>Roelens, Ingele</creator><creator>Jacob, Sandrine</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7SS</scope><scope>7TM</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20060101</creationdate><title>CoREST-like complexes regulate chromatin modification and neuronal gene expression</title><author>Lakowski, Bernard ; Roelens, Ingele ; Jacob, Sandrine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-c07e80be6e610721a1c0e3b6941a53efb6c3b4652cecdf88773db91b4bc969633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Arabidopsis Proteins - 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Academic</collection><jtitle>Journal of molecular neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lakowski, Bernard</au><au>Roelens, Ingele</au><au>Jacob, Sandrine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CoREST-like complexes regulate chromatin modification and neuronal gene expression</atitle><jtitle>Journal of molecular neuroscience</jtitle><addtitle>J Mol Neurosci</addtitle><date>2006-01-01</date><risdate>2006</risdate><volume>29</volume><issue>3</issue><spage>227</spage><epage>240</epage><pages>227-240</pages><issn>0895-8696</issn><eissn>0895-8696</eissn><eissn>1559-1166</eissn><abstract>The mammalian CoREST ([co]repressor for element-1-silencing transcription factor) complex was first identified associated with the repressor for element-1 silencing transcription factor (REST)/neuronal restrictive silencing factor. The CoREST complex is a chromatin-modifying corepressor complex that acts with REST to regulate neuronal gene expression and neuronal stem cell fate. Components of a CoREST-like complex have been identified recently in Xenopus laevis, Caenorhabditis elegans, and Drosophila melanogaster. Like the mammalian complex, the Drosophila complex is required to regulate neuronal gene expression, whereas the C. elegans homologs regulate the expression of the hop-1 presenilin gene, suggesting an ancient conserved function of CoREST complexes in regulating neuronal gene expression.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>17085781</pmid><doi>10.1385/JMN:29:3:227</doi><tpages>14</tpages></addata></record> |
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| subjects | Animals Arabidopsis Proteins - physiology Biological Evolution Caenorhabditis elegans Caenorhabditis elegans Proteins - physiology Chromatin - genetics Chromatin - metabolism Co-Repressor Proteins DNA-Binding Proteins - physiology Drosophila melanogaster Drosophila Proteins - physiology Epigenesis, Genetic Gene expression Gene Expression Regulation Genetics High Mobility Group Proteins - physiology Histone Deacetylase 1 Histone Deacetylase 2 Histone Deacetylases - physiology Histone Demethylases Humans Insects Invertebrates - genetics Invertebrates - metabolism Mammals - genetics Mammals - metabolism Mice Multiprotein Complexes - physiology Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics Nerve Tissue Proteins - physiology Neurons - metabolism Oxidoreductases, N-Demethylating - physiology Promoter Regions, Genetic Proteins Proto-Oncogene Proteins c-raf - physiology Repressor Proteins - physiology Transcription Factors - physiology Transcription, Genetic - physiology Xenopus laevis |
| title | CoREST-like complexes regulate chromatin modification and neuronal gene expression |
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